Sentences with phrase «many other animal models»

They also stopped making new brain cells, something that has also been seen in other animal models of depression.

They found that, within the first three days of injury, fish in the concussion group were slower to find a school of fish with which they previously swam, a measure of spatial memory which is impaired in other animal models of concussion and human patients.

Researchers are, however, continuing to explore microbiome interactions using other animal models.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

The researchers now plan to test this type of insulin in other animal models and are also working on tweaking the chemical composition of the insulin to make it even more responsive to blood - glucose levels.

«Usually, when researchers want a mouse or other animal model to express fluorescent proteins in certain cells, they need to develop genetically modified animals that can take months to years to make and characterize,» says former graduate student and first author Ken Chan (PhD» 17).

If the findings of the study are replicated in other animal models, such as pigs, they could have considerable implications for public health, says Oluf Pedersen, professor of genomic medicine at the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen.

«We will eventually negotiate a path to getting permits for highly innovative projects where there is no other animal model available,» he says.

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

In the case of influenza, mAbs have been shown to provide prophylactic or therapeutic protection in mice and other animal models (Reuman et al., 1983; Sweet et al., 1987; Palladino et al., 1995; Renegar et al., 2004).

Additionally, the wheel lock and other animal model suggest that exercise during youth may help preserve muscle mass over the course of aging and lower the activity of genes associated with cardiovascular disease.

Such models are valuable for the analysis of parameters associated with vaccine safety, immunogenicity, delivery and protection as NHPs replicate key features of the human immune response more faithfully than any other animal model.

Here we used our knowledge of the developmental biology of many other animal models to provide the positive and negative signaling factors to guide the developmental choices of these tissue and organ stem cells.

Using the wheel lock model and other animal models for studying childhood obesity is giving scientists more insight on exactly what happens when activity is restricted during youth, leading to obesity.

Scientists need other animal models as well, and major breakthroughs have been made and are in the process of being made thanks to studies conducted with these animals:

Other animal models either express oncogenes in a tissue - specific manner or shut down the expression of tumor suppressor genes in the whole tissue.

Thus, the analytical tools developed by the Schroeder lab to identify structures and functions of biogenic small molecules will be transferable to other animal models.

This proposed role for GM1 (and indirectly GD1a) provides a rationale for its potency in suppressing diabetes in NOD mice (10) and disease onset in other animal models of autoimmunity.

After discussing similar effects in other animal models of cancer and a few studies showing the ability of antioxidants to prevent cancer growth, Campbell concluded that «a pattern was beginning to emerge: nutrients from animal foods increased tumor development while nutrients from plant - based foods decreased tumor development.»

«Thus it seems that outside of [genetically engineered mice or a cell culture dish or other animal models] that the search for the true role of the growth potential for IGF - 1 in adult muscle hypertrophy is a vain one.»

However, data from other animal models demonstrate diminished lysosomal enzyme activity during extended periods of energy restriction (39).

Not exact matches

Two other hooded sweatshirts in the line, one that says «Survival Expert» and one covered in an animal - shape print, were modeled by white children.

The animals and activities and colors on the jumperoo are engaging and not boring like other models on the net.

10 There is no animal model of SIDS and it has never been observed to occur naturally in any species other than humans.2 While the standardization of a SIDS diagnosis has been and continues to be elusive and / or inconsistent, it is most often applied to situations in which an otherwise healthy infant between the ages of 8 - 16 weeks, especially, but up to 12 months, dies suddenly and unexpectedly presumably during its sleep and upon postmortem examination no apparent internal causal factor (s) explaining the death can be identified.11, 12

«What we had done for the cystic fibrosis pigs was applicable to other diseases» for which the previous animal models were not sufficient, Rogers says.

«Gene - delivery system prevents vision loss from inherited eye disease: Initial testing in animal models holds promise for treating Leber congenital amauroisis and other congenital visual disorders.»

New research from McLean Hospital neuroscientists shows in an animal model that being bullied can have long - term, dramatic effects on sleep and other circadian rhythm - related functions, symptoms that are characteristic of clinical depression and other stress - induced mental illnesses.

«Before our work in rhesus monkeys, it has not been possible to detect or observe some of these symptoms in other HD animal models, especially emotional dysregulation,» says senior author Chan, associate professor of human genetics at Yerkes National Primate Research Center and Emory University School of Medicine.

Other projects aimed to show that animals have a theory of mind, the ability to model the thinking of others (as when we judge whether a poker player is bluffing or if a potential mate is truly in love).

Chief among the criticisms were the animal's hindlimbs, significantly smaller compared with other large predatory dinosaurs, as well as other researchers» theoretical Spinosaurus models.

She kept feeding the new data into mathematical models that factored in the animals» age, migration patterns and disease prevalence in the population, among other things.

Animal model testing is already underway, and Mikovits notes that her team is looking into some reverse transcriptase inhibitors that have already been approved by the U.S. Food and Drug Administration for other uses.

Still, he says, other groups have arrived at opposing results regarding the role of T cells in the disease, in part, perhaps, because their animal models aren't the same.

As for the animal model, the researchers hope to now conduct experiments in monkeys or other species that more closely resemble humans.

Importantly, the development of a new animal model for Dravet syndrome based on reduced CHD2 expression might help to find effective treatments that could improve the lives of thousands of people suffering from Dravet syndrome and perhaps other genetic epilepsies.»

More work is needed to determine whether the findings on rapamycin hold true in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is altering the metabolism of the cells.

He sees the capability of using the team's research in the future to design models that will help game managers, conservation managers, farmers and tour operators predict animal migration, whether it's zebras or other migratory animals.

The scientific model used to explore human minds applies to other animals.

In five other studies published over the past year, Taffe, Dickerson and their laboratories have looked at the effects of MDPV and a related «bath salts» cathinone derivative, mephedrone, in a range of animal models.

«The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate elimination of HIV - 1 DNA in latently infected T cells and other sanctuary sites for HIV - 1, including brain cells,» Dr. Khalili said.

«Mature B lymphocytes accelerate the healing of diabetic ulcers, other skin injuries: Direct application of immune cells speeds and improves healing of acute and chronic wounds in animal models.»

«This is why we are investigating in animal models how the nerve cells within the entorhinal cortex are connected with each other.»

In past studies to develop a new animal model for the brain events that support motor development, neurophysiologist Martin Garwicz of Lund University in Sweden and his colleagues discovered that the schedules by which ferrets and rats acquire various motor skills, such as crawling and walking, are strikingly similar to each other; the progress simply happens faster for rats.

«I'm hopeful the techniques successfully used in this study can be applied to make animal models for other neurodegenerative diseases,» he says.

Bearden says she and her team are collaborating with other scientists to investigate brain structural differences in animal models, to find out what causes them at the cellular level.

But this remarkable therapeutic benefit isn't limited to MS. Previous research in animal models that mimic other diseases suggest that certain forms of amyloids can ease damage from strokes, traumatic brain injuries and even heart attacks.

(At the other extreme, animals such as horses, who have a long gestation and then walk almost immediately after they are born, also fit the model.)

It's not clear what would happen to the rest of NCRR's portfolio, which includes support for construction and instrumentation, primate centers and other model animal resources, and grants for minority institutions and states that don't have much NIH funding.

The recommendations are all the more critical given that the models don't take into account other threats to lemurs and the many animals that share their forest home, the researchers say.

«In less than a year, our group and others have demonstrated that multiple vaccine platforms can provide robust protection against Zika virus challenge in animal models.