Sentences with phrase «many other tumor»

If your doctor finds other tumors, you may need a mastectomy to remove the entire breast.

If there are no other tumors present, treatment includes surgery to remove the nipple and areola, followed by a series of radiation treatments on the whole breast.

Wong and his lab want to see if edelfosine could be incorporated into future clinical research focused on other tumor sites such as lung, ovarian and pancreatic cancers.

Even though this is a relatively rare cancer, we know HPV is important in a number of other tumors, including those of the head and neck.

In past imaging studies, my colleagues and I noticed that cervical tumors that took up a lot of glucose prior to radiation treatment tended to be more resistant to radiation therapy than other tumors.

«This finding,» Villanueva said «opens the door to developing new biomarkers and new therapeutic strategies exploiting these characteristics of exosomes in breast tumors, and other tumors such as ovarian and endometrial cancer among others.»

Because the combination destroys other tumors besides the injected one, it might eliminate metastases, or the secondary tumors that result when cancer spreads, he says.

The shots trigger the animals» immune system to eliminate not only the injected tumors, but also other tumors in their bodies.

The study published in Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cells.

However, the cancer cells of individual other tumor facets of the same patient survived the treatment and were even able to reproduce much more intensively.

Long - term use of mifepristone has been studied in clinical trials for other tumors, with minimal adverse effects reported after years of usage.

Although other tumor suppressors exist, what makes Par - 4 so special is that it is not mutated as frequently as other known suppressors, and it's «selective» in its actions in that Par - 4 will only kill cancer cells and not normal cells.

The HER2 gene is overactive in more than one - fifth of all breast cancers and operates in a host of other tumors that may prove vulnerable to oleic acid.

«It would be great to see this in other tumor models.»

XL184 inhibits two important treatment escape pathways, VEGF and MET, but while it has FDA approval to treat thyroid cancer and is being tested against pancreatic cancer and several other tumors, it is quite toxic requiring dose restrictions or treatment interruption.

They work particularly well if the cancer cells they attack already have defects in the corresponding DNA repair pathways, as it frequently occurs in breast cancer and other tumors.

And if fetal cells protect women from breast cancer, they might also safeguard against other tumors.

«Since patients with many types of cancer have elevated levels of myeloisd cells in their blood, it's possible that other tumors could have a similar interaction with bone to increase myeloid cell production.»

Researchers now think that irradiation sometimes kills tumor cells in a manner that exposes new antigens to T cells, priming them to target other tumor cells that carry them as well, says Wenbin Lin, a chemist at the University of Chicago in Illinois, and one of the authors of the current study.

A larger study to address this, as well as other fluorescent agents for other tumor types that do not express FRα, are being planned, Burggraaf added.

«It was the only marker we could find on her tumor; and it turns out, on just about every other tumor we tested, too.»

Using cultured cells derived from human tumors of the breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.

She also noted the targeting Msi in primary tumors significantly changed «the trajectory of progression by halting pancreatic cancer growth and improving survival,» inhibiting both cancer stem cells and other tumor cells.

Both strains spread through the tumors, infecting and killing the cancer stem cells while largely avoiding other tumor cells.

This is an unusually large amount of drivers, not typical for many other tumor types, according the study's senior author Dr. Matthew Wilkerson, associate professor and Bioinformatics Director of The American Genome Center and the Collaborative Health Initiative Research Program at USU.

Searching for T cells that had infiltrated the tumors, they collected as many as 50 T cell samples from a single tumor; next, the team tested each batch of T cells against other tumor samples from the same patient.

Among these is BRG1 (also called SMARCA4) and the latest generation - sequencing technologies have extended these findings to other tumor types evidencing that BRG1 inactivation is widespread in cancer.

TCGA is still worth it, he says, but «the return on the investment [for this cancer] is less than for other tumor sites.»

Furthermore, the agent prevented the drop in the number of neutrophils (i.e., neutropenia) found in the blood that is typically caused by 5 - fluorouracil, a chemotherapy agent commonly used in the treatment of gastrointestinal and other tumors, such as colon, stomach, pancreas and breast cancers.

In further studies, they plan to explore the role of autophagy in immune reactions toward other tumor cell types, to determine whether such therapies might be effective in a broad range of cancers.

But the other tumor types may require more aggressive measures to prevent relapse, including chemotherapy and sometimes investigational drugs.

«Most other tumors have a mutant p53, but in these testicular cell tumors, the p53 is functioning properly, and the drugs used for testicular cancer appear to work in concert with p53's tumor suppression function to kill the cancer cells.»

Tumors on two of the mice disappeared after 7 days, whereas the other tumors shrank to about half their original size.

«Our results clearly demonstrate a significant, although unexpected, role for specific gut bacteria in enhancing the immune system's response to melanoma and possibly many other tumor types,» said study director Thomas Gajewski, MD, PhD, professor of medicine and pathology at the University of Chicago.

Investigators also found genomic similarities between endometrial cancers and other tumor types.

It will offer patients «off label» access to various drugs already used for other tumor types or purposes, and collect information on how they fare.

It can be proposed that p21 contributes to mediate p53 - dependent tumor suppression in some tumor types, which would include histiocytic sarcomas, hemangiomas, B - cell lymphomas, and lung carcinomas, but not in other tumor types, particularly spontaneous or radiation - induced T - cell lymphomas.

Two cases harbored mutations in isocitrate dehydrogenase 2 (IDH2), a gene known to be recurrently mutated in AML, glioblastoma, and other tumors.

To get there, researchers will need to resolve certain obstacles associated with CAR - T, including further customization of the technology to recognize specific / other tumor types, and predicting and limiting cross-reactivity, where CAR - T immune cells start attacking healthy cells as well.

The researchers write that expression of DNRII also may be useful for other tumors that exploit this immune evasion mechanism, including melanoma and lung cancer.

These findings reinforce many things that we already know: that mutations acquire gradually with age, that most of the mutations in AML (and likely other tumors) are random background events not contributing to tumorigenesis, and that subsequent mutation and evolution can give rise to subclones that ultimately determine cancer progression and response to therapy.

Similar effects of rapamycin have been shown in other tumor types.

These signaling molecules may also play a role in tumor development in other organs, and are being evaluated in melanoma and other tumor types.

The cancers with most Eph receptor mutations are shown; other tumor types have fewer or no Eph receptor mutations.

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He continues to study cancer gene function in his Georgetown lab, and has recently identified a new cancer gene called STAG2 that is among the most commonly mutated genes in cancer, involved in causing bladder cancer, pediatric bone tumors, leukemias, brain tumors, and other tumor types.

Swanton's lab has since followed the work with comprehensive spatial and temporal genetic analyses of other tumor types, including colorectal cancer, showing the ways that faulty DNA replication promotes chromosomal instability in cancer.

Alarmingly, and despite indisputable success achieved in the treatment of these malignancies, their incidence in westernized countries during the last 3 decades has been increasing more rapidly than that of most other tumors.

Also, CMB305 was well tolerated, and generated a strong and broad anti-NY-ESO-1 immune response in > 50 % of the patients, including evidence of antigen spreading — the induction of an immune response against other tumor antigens not targeted by CMB305.

The exposure to epacadostat was lower in these patients than in patients with other tumors.