Sentences with phrase «many prior therapies»

We also detected circulating tumour cells, which were found in higher numbers in patients who had received more prior therapies.

«For patients who have not responded to prior therapies, this drug now provides a very real chance to shrink their tumors and the hope of a lasting response to treatment.»

The Phase 2, double - blind trial enrolled 142 patients with advanced melanoma who had not received prior therapy.

Prof Soria will say: «Re-sensitisation to TKI can not account for the majority of these responses, since most patients had come off TKI as their immediate prior therapy.»

The median number of prior therapies for these patients was three; all the patients had been treated previously with at least one other EGFR TKI therapy, and most patients receiving chemotherapy as well.

A class of oral specialty drugs, tyrosine kinase inhibitors (TKIs), has revolutionized the treatment of CML, largely transforming it into a chronic condition and enabling many patients to have a near - normal lifespan, particularly when compared to a median survival of less than three years with prior therapies.

The FDA approved Opdivo ® (nivolumab) for the treatment of patients with metastatic squamous non-small cell lung cancer (NSCLC) after prior therapy.

The median age of the patients is 61 and all are heavily pretreated — the median number of prior therapies was 6.3.

Responses to the combination therapy did not correlated with prior chemotherapy, the number of prior rituximab doses, or duration of response to prior therapy.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

The trial included 63 patients with histologically confirmed marginal zone lymphoma who had received one or more prior therapy including at least one CD20 monoclonal antibody.

Ibrutinib is also approved to treat chronic lymphocytic leukemia / small lymphocytic lymphoma, including patients with 17p deletion, mantle cell lymphoma after at least one prior therapy, and patients with Waldenstrom macroglobulinemia.

Eligible patients must have had at least two prior therapies including lenalidomide and a proteasome inhibitor to receive daratumumab.

The patients were all high risk and had received many prior therapies.

The applicability rating of blended interventions for individual therapy was clearly less positive (48 %), while prior therapy experience (54 %) did not predict this appraisal (r = 0.116, p = 0.580).

It will also increase your overall happiness and may lower your divorce rate by 31 % in comparison to couples who go into marriage without any prior therapy.

Not exact matches

Prior to Human Longevity, Collins was the CEO and general manager of GE Healthcare's cell therapy division for three years.

Prior to being elected, Selina had a home - based family therapy practice, was the Director of Development for SHARE Family and Community Services and was a Counselling Instructor and Program Developer at the University of British Columbia's Life and Learning Centre and Vancouver Community College.

Appropriate care for the previous generation involves, among other things, what family therapist Murray Bowen has called «differentiation of the self from the family of origin» (see Family Therapy and Clinical Practice [Aronson, 19781) Those who work professionally with families have found that people experiencing marital or other family pain frequently have an unfinished agenda with the prior generation.

Dwyane Wade told the Associated Press that his left knee, injured in a collision with Spurs guard Manu Ginobili a game prior, required a draining of fluid and nearly eight hours of therapy heading into Game 7 of the NBA Finals.

Prior to becoming involved in politics, Charlotte was the CEO of Big White Wall, a socially responsible business spearheading the provision of mental health therapies online.

Prior to building her massage therapy practice, Jenny did graduate and undergraduate work in psychology, women's health and early childhood development.

Beginning in 2009, they used functional magnetic resonance imaging (fMRI) to scan the brains of patients prior to treatment for depression; they then followed the patients through the course of therapy, generally for four weeks.

Dr. Glen Weiss, M.D., M.B.A., is the first author of the study abstract: Phase Ib / II Study of Pembrolizumab plus Chemotherapy in Advanced Cancer: Results of lung cancer patients receiving (at least) 1 prior line of therapy.

In past imaging studies, my colleagues and I noticed that cervical tumors that took up a lot of glucose prior to radiation treatment tended to be more resistant to radiation therapy than other tumors.

Prior studies have looked at the usefulness of laboratory monitoring during isotretinoin therapy.

«Considering that no prior research has conclusively demonstrated benefit of corticosteroid therapy for any manifestation of Lyme disease, including neurologic, rheumatologic or cardiac manifestations, we urge strong caution in prescribing corticosteroids in cases where facial paralysis is clearly the result of acute Lyme disease until better evidence is available,» said Dr. Jowett.

The ability to identify those patients unlikely to respond to first - line biologic anti-TNF therapies prior to their treatment would allow these patients to be prescribed alternative therapies, providing faster relief of symptoms and reducing the risk of future complications.

More than a third had received at least six prior lines of therapy without lasting success.

Hormone therapy was associated with a net decrease of 0.3 — 0.4 QALYs in men with a prior history of heart attack.

«These tumors often resist therapy but currently can not be identified prior to treatment.

Specifically, long term follow up of a randomized clinical trial that compared ADT and radiation therapy (RT) to RT alone finds that men with significant comorbidity; most commonly prior heart attack, who received ADT died earlier, due to a fatal heart attack, compared to men who did not receive ADT.

Results of a comprehensive cost - effectiveness analysis suggest that patients who have RA and no contraindications to triple therapy should use it prior to a biologic as the next regimen.

In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators at Dana - Farber Cancer Institute and other organizations report today online in the New England Journal of Medicine.

The new study involved 72 patients, all of whom had received at least two prior lines of therapy and whose disease had relapsed and no longer responded to treatment.

«Prior to the surgery, each patient went through physical therapy focused on getting them to the point where they couldn't get any better.

The ICD Registry identifies an opportunity for the use of medical therapy for patients with prior myocardial infarction or left ventricular systolic dysfunction; nearly 25 percent of ICD patients did not receive optimal medical therapy with ACE inhibitors and / or beta blockers at discharge.

The effect of the GS - DProSw molecule can be «switched off» by ultraviolet light prior to therapy.

Prior to this these interfaces were thought of as potential assistive technologies, not as therapies.

The results, which will be published Sept. 24 in JAMA Psychiatry, follow prior Stanford research that found a family - based approach was twice as effective as individual therapy for treating adolescent anorexia patients.

Lock, who has conducted several prior studies of the therapy that teaches parents to help their children eat normally again, said he thinks this approach works by interrupting the patient's behaviors that are supporting erroneous thinking patterns.

The manufacturer did not submit any studies for pretreated patients in which the comparator therapies were notably adapted to the results of the prior treatment.

The way forward for fracture prevention involves not only the development of better therapies to prevent fracture and easier delivery systems but also improved adoption of existing osteoporosis therapies for patients with prior fractures and minimization of adverse effects, particularly those associated with long - term use.»

Although there remains no cure for Alzheimer's, researchers hope that testing potential drugs or therapies prior to mental decline will prove to be more successful than previous attempts at finding the most effective treatment in the battle against the debilitating disease.

The research team developed a new method called highly multiplexed single - nucleus sequencing (HM - SNS) to investigate CNA's clonal substructure and evolution in a cohort of 12 TNBC patients, whose tumors had been surgically removed prior to further therapy.

IGRT is the process of using frequent imaging, typically performed in the treatment room prior to radiation delivery, throughout a patient's course of radiation therapy treatment to improve localization of the target and normal structures, which allows for more precise and accurate radiation delivery.

«We believe that the new criteria will rectify the situation where we were unable to use the considerable advances in multiple myeloma therapy prior to organ damage.

Prior to the WHI, the accepted view among physicians was that estrogen therapy reduced a woman's risk of developing cognitive impairment.

«The unusual genetic instability of GEA tumors enables them to evolve and diversify even prior to receiving therapy.

Importantly, without any prior knowledge from the analysis of tumor tissue, 76 % of «actionable» mutations (genetic changes that can be matched to an approved targeted therapy or one being tested in clinical trials) detected in tissue were also detected in blood.