Sentences with phrase «many second messengers»

The researchers assume that this is the signal that sparks off the response: The bacterial cell now boosts the synthesis of a second messenger, which in turn stimulates the production of an adhesin that firmly anchors the bacteria on the surface within a few seconds.

Catecholamines signal through the β2 - adrenergic receptor by promoting production of the second messenger adenosine 3 ′, 5 ′ - monophosphate (cAMP).

Adenylyl cyclase (AC) converts adenosine triphosphate (ATP) to cyclic adenosine monophosphate, a ubiquitous second messenger that regulates many cellular functions.

The current study revealed that amlexanox exerts its effects through a specialized type of fat cell by increasing the level of a second messenger molecule called cAMP.

cAMP is a second messenger.

Each such «second messenger» is a crucial guide for the cell, helping to determine how the cell responds to the organism's needs

The recent explosion of green fluorescent protein (GFP) based sensors of pH, halides, proteases, kinases, G proteins, and many second messengers (including Ca2 +, cAMP, cGMP, nitric oxide, and IP3) have provided important tools for the design of screening assays.

Nitric oxide is a critical second messenger in the body, playing roles in vascular homeostasis, neurotransmission and host defense.

These molecules include eicosanoids prostaglandin E2, leukotriene B4 and thromboxane TXB2, second messengers cAMP and cGMP, as well as bile acids, conjugated steroids, and folic acid.

A new cell permeant IP3 antagonist offers a useful tool for exploring the second messenger pathway.

More recent evidence shows that an alternative second messenger, nicotinic acid adenine dinucleotide phosphate (NAADP), also has a role to play, causing researchers to question established calcium releasing pathways.

Zinc is a novel intracellular second messenger.

DGKζ, a lipid kinase, phosphorylates the second messenger DAG, terminating DAG - mediated activation of RasGRP1 and PKC - θ, whereas Cbl - b, an E3 ubiquitin ligase, facilitates ubiquitination and subsequent degradation of the p85 subunit of PI (3) K. Previous studies have evaluated numerous aspects of T cell biology in the two models (16 — 18, 25, 38), but the signaling and functional effects of DKGζ deficiency and Cbl - b deficiency in T cells had not been directly compared.

Here we show how second messengers relevant to the Gq signaling pathway can be detected in living cells using assays for DAG, PIP2, and Ca2 +.

Inositol is a sugar that can serve as a precursor for a membrane phospholipid (phosphatidylinositol), a second messenger in signal transduction, an osmolyte, or an energy source.

In Gq - coupled signaling, DAG and intracellular calcium act as second messengers, ultimately influencing cell functions.

Two methods published by BMG LABTECH describe (1) real - time detection of Gs and Gi signaling and (2) detection of GPCR second messengers in living cells.

These versatile tools enable quantitative, functional imaging of molecular interactions, protein activities or second messenger concentration in single living cells.

The combined activity of second messengers and enzymes (lipases, kinases, phosphatases and GEFs) yields a physiological response.

This process is mediated by of a diverse set of signaling molecules, i.e. enzymes, second messengers, scaffolds and transcription factors.

This has been used to create reporters for second messengers by using protein (domains) that undergo a conformational change upon binding of e.g. Ins (1,4,5,) P3, calcium or cAMP.

Both DAG and calcium are essential second messengers which activate downstream signaling components such as protein kinase C and calmodulin dependent kinase.

Not exact matches

Second, while the messenger style bag looks great, when loaded to the brim, it puts a lot more strain on your body than a more ergonomic backpack.

If you watch closely, you will notice that SoftBank has typically invested in the second largest, if not the largest player, in any industry â $ «be it cab aggregators, e-commerce players, messengers or hotel aggregators.

11:19), Jesus is apparently referring to himself in some sense as a special messenger of God, but there is no suggestion here of a supernatural and apocalyptic second coming.

He can send his commandments down from Mt. Second Floor and have his messenger Moses Dicker smash the tablets at the feet of the idolators and the lobbyist and the moneychangers amd the hospital and teacher's unions.

On April 30, if all goes well, after running out of fuel to fight off orbital decay NASA's long - running MESSENGER spacecraft will end its mission to Mercury by crashing into the planet's surface at nearly 4 kilometers per second.

In his second semester, he started doing research in three different labs, including that of Carolyn Decker, a molecular biologist who was investigating how the cell controls gene expression through the destruction of messenger RNA.

This marks the second time in four years that the chemistry Nobel has been awarded to someone working with x-ray crystallography; in 2006 Roger Kornberg took the prize for detailing the structure of messenger RNA, which is the molecule that carries the information the ribosome uses to build proteins, such as insulin or hemoglobin.

In the second phase, the reduction in messenger RNA causes less of the AtGRP7 protein to be formed.

Messenger Spacecraft: NASA's second mission to Mercury is named MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging).

On October 6, 2008, NASA's MESSENGER spacecraft made its second of three flybys around Mercury, to be undertaken before it settles into orbit around the innermost planet in March 2011.

The nervous system can make very quick changes in a fraction of a second by sending electrical impulses through the spinal cord to the muscles, or it can make slow changes by sending chemical messengers, called hormones, into the blood to reach the tissues and the organs.

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He's wearing an eyepatch and carrying a bundle of papers, which he hands over to Downey's character like a messenger handling the afterthought of the second half of the script.

If a «Director's Cut» DVD were to ever emerge with a half hour more that would explain just what's behind the Jumper phenomenon, the Paladin counter group, and with more time given to co-stars who would normally have gotten much more screen time (Diane Lane (Hollywoodland, Must Love Dogs), Kristin Stewarrt (The Messengers, Zathura), and AnnaSophia Robb (The Reaping, Bridge to Terabithia) have performances that probably ended up largely on the cutting room floor), then perhaps I might give the flick a second chance.

The second day of this festival, Kukur Puja, also known as Diwali, worships dogs, who are believed to be messengers of the God of Death.

Calm and gentle they were used as pack and messenger dogs by the French during the second World War.

A second problem with Atopica is that the calcineurin messenger compounds that it blocks are also found in your pet's kidneys.

The date honors the launch of the US Army K - 9 Corps program in 1942 and the memory of the brave Belgian Sheep Dogs, Doberman Pinschers, Eskimo dogs, Collies, German Shepherds and Malamutes who trained to become messengers, sentries and scouts during the second World War.

Second, they need a way to add and remove instant messenger contacts on the Xbox 360.

This is shooting the messenger long before he has a chance to think about his second post, but... I got to thinking what I would want in the Stormhoek manifesto, which made me start by thinking what is Stormhoek?

Firstly, I have no need of Mann's code (this isn't my field) and secondly, I have only your word about the second issue — this is your dispute, not mine and I am certainly not your messenger boy.

The social messenger Telegram has closed the second round of its token sale, attracting $ 850 million.

Messengers of the «avoid using an objective & # could do a better job of explaining themselves, no doubt, and those on the opposing side should avoid building up drama, leading with criticism, and offering split - second «fact & # interpretation.