Sentences with word «maraviroc»

Only two of 10 mice, exposed to the liquid and given a combination of maraviroc and a VEGF - blocking drug, developed metastases.

Because the anti-retroviral drug maraviroc has already been approved by the U.S. Food and Drug Administration and has been shown safe for long term, oral use, it could be tested in clinical trials sooner rather than later, says Aleksander Popel, Ph.D., a professor in the Department of Biomedical Engineering at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Kimmel Cancer Center.

Because maraviroc blocks the actions of CCL5, it could be delivered, along with standard chemotherapy, right after surgically removing a tumor in a bid to prevent any leftover circulating tumor cells from finding a new metastatic niche in the body, Popel says.

In the same report, the researchers say maraviroc, a drug already approved for treating HIV infection, blocked the siren call of CCL5 in tests on animals and cells and prevented tumor spread (metastasis).

In theory, the success of this approach could be recapitulated by inhibiting CCR5 with an orally bioavailable small molecule such as maraviroc, which binds to CCR5 and prevents its use by most R5 HIV - 1 strains.

Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification.

Additional experiments using a combination of maraviroc and a drug that blocks the VEGF protein suggest that the treatment duo could be an effective way to prevent metastatic disease in human breast cancer patients, according to the researchers.

Earlier this year phase III results came in for two other new drugs, Pfizer's maraviroc and Merck's raltegravir, each of which is the first in a new antiretroviral category and leads to undetectable levels of drug - resistant virus in about half of studied cases.

Pfizer's Selzentry (generic name, maraviroc), which went on sale in the United States in September, binds with host cell receptors to prevent the virus from attaching to and entering healthy host cells.

Drugs known as entry inhibitors (Pfizer's maraviroc and Schering - Plough's vicriviroc) stop the virus from entering healthy cells by binding to receptors on the cells» surfaces.

New HIV Fighter In August, Pfizer got the go - ahead to sell Selzentry (maraviroc).

Selzentry (maraviroc, made by Pfizer) prevents HIV from entering white blood cells.