Simultaneous T
cell antigen receptor (TCR) analysis in single
cells and bulk subsets revealed that CD4 - TEMRA
cells show
marked clonal expansion compared with TCM and TEM
cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in
donors with previous DENV infection.
His team has used CRISPR gene editing to also disable the gene for the HLA proteins that
mark a
donor T -
cell as foreign, reducing the chances of the recipient's immune system attacking the
donor cells.