... [For example], A deficiency of lysosomal sialidase (Neu1) leads to increased levels of LAMP -1-mediated lysosomal exocytosis by neutrophils in the
bone marrow cavity.
Because the bone marrow must struggle to make enough hemoglobin,
the marrow cavities enlarge, causing deformities especially in the facial bones.
Animal studies show that it directs the size of
the marrow cavity in bones in rats.
Radiologically and histologically, it can be 2 months between onset and the beginning of the late phase, and then several more months before cortex and endosteum (inner lining of
the marrow cavity) regain normal appearance.