Sentences with phrase «marrow microenvironment»

In the bone marrow microenvironment, CLL cells are protected from spontaneous or drug - induced apoptosis, resulting in resistance to conventional chemotherapy.

The Nefedova laboratory focuses on understanding the role of bone marrow microenvironment in regulation of tumor progression and therapy resistance.

Nefedova studies molecular mechanisms by which bone marrow microenvironment promotes tumor survival and progression.

Contained in spongy bones, the bone marrow microenvironment and its «niches» support production of platelets and other blood cells.

Basic research has centered on identifying and characterizing hematopoietic stem cells, however, it is still not clear how hematopoietic stem cells actually work, and how they are regulated because of the complexity of the bone marrow microenvironment.

Not exact matches

«Taken together, these results support the hypothesis that multiple myeloma cells express bone - related genes in a Runx2 - dependent fashion that mimics bone marrow resident cells and likely contributes to tumor survival and growth in the bone microenvironment,» Yang and colleagues wrote in the paper.

In conjunction with bone marrow tissue cells, these HSCs form a microenvironment known as a niche.

Modeling multiple myeloma - bone marrow interactions and response to drugs in a 3D surrogate microenvironment

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

Marina Prewitz (Werner, LG)-- «Decellularised extracellular matrices as instructive microenvironments for bone marrow derived stem cells» (2011)

The authors also highlight a recent report on the production of platelet from mouse fetal - liver culture - derived MKs using a biomimetic microfluidic platelet bioreactor [5], which may allow the further enhancement of MK production from hiPSCs by the recapitulation of the bone marrow and blood vessel microenvironments.

They asked: How can the marrow, which is highly permeated with blood capillaries, harbor blood stem cells in a low - oxygen microenvironment?

In her project, Sipkins will investigate molecular characteristics of tissue microenvironments, or «niches,» within the bone marrow and how normal, healthy hematopoietic stem cells, which give rise to the many kinds of blood cells, compete with malignant cells to occupy these coveted niches.