The researchers obtained bone
marrow samples from patients prior to chemotherapy, and from those samples drew both leukemia cells and immune system cells.
If the FLT3 mutation is detected in blood or bone
marrow samples using the LeukoStrat CDx FLT3 Mutation Assay, the patient may be eligible for treatment with Rydapt in combination with chemotherapy.
DNA was isolated from blood and bone
marrow samples using the QIAamp DNA Blood Maxi Kit (Qiagen, Valencia, CA), and cDNA was synthesized from RNA using random hexamer priming.
In bone
marrow samples from middle - aged volunteers, her team had found antibody - secreting cells that survive from childhood infections.
When possible, scientists will also collect and store other biological specimens such as leftover tumor or bone
marrow samples.
This work was made possible by the generous contributions of blood and bone
marrow samples by AML patients to research.
«It is no longer good enough to examine bone -
marrow samples and say the leukemia is gone,» Bloomfield says.
This led to the collection of bone
marrow samples from larger cohorts of patients with the Ottawa Hospital Research Institute, as well as those from Western University and Hamilton Health Sciences, for the next steps of investigation.
The 3 - D tissue - engineered bone marrow (3DTEBM) cultures pictured were developed with bone
marrow samples to help determine which treatments are most effective.
The researchers identified the LSC17 score by sampling the leukemia stem cell properties of blood or bone
marrow samples from 78 AML patients from the cancer centre combined with molecular profiling technology that measures gene expression.
The team started by analyzing bone
marrow samples from children with B - ALL and cataloging every protein present in the leukemia cells.
These findings are in agreement with other studies on cell morphology [3, 4] and senescence [5], and the authors hope to advance these studies by separately analyzing subpopulations derived from the same bone
marrow sample, and also surveying the grade of cell maturity (surface receptor analysis) and cytoskeleton composition of the cells during cell tracking.
A bone
marrow sample may be taken if estrogen toxicity is suspected.
Not exact matches
You can stick with the small dishes section,
sampling pan-fried leek buns scented with curry or spicy laab over bone
marrow.
In the study, «Succinate and its G - protein - coupled receptor stimulate osteoclastogenesis,» the researchers took
samples of bone
marrow from hyperglycemic male mice and healthy mice.
The team took
samples from Ata's bone
marrow and sequenced the DNA, mapping it against a human reference genome.
To treat hereditary blood diseases, doctors could take a
sample of bone
marrow cells from a patient, correct the faulty gene, and then grow healthy cells in the bioreactor and transplant them back into the patient.
The researcher team from the University of Birmingham, New Cross and Heartlands Hospitals compared the cellular chemistry of bone
marrow and blood
samples taken from patients with myeloma, patients with MGUS and healthy volunteers.
Supply of biological
samples (blood, plasma, bone
marrow, cerebrospinal fluid, serum, unrine, tissues, organs)
The group assessed bone
marrow MSCs
sampled from 23 patients between the ages of 17 and 67 years old.
Cord blood provides several benefits over bone
marrow, including the need for less stringent HLA - matching, though its utility can be limited by the availability of fewer HSCs in each
sample.
Samples of blood, bone, and bone
marrow are removed for examination under a microscope.
With our NGS - based assays, the gene rearrangement status of several million lymphocytes in blood, bone
marrow, or tissue
samples can be both identified and characterized.
This discordance may be related to the
sample variation between the trephine biopsy and aspirates because of heterogeneous or patchy
marrow involvement, a failure to aspirate sufficient lymphoma cells, or insufficient primer homology for amplification.
Our researchers are actively collecting
samples of blood and bone
marrow (voluntary) from patients with Diamond - Blackfan anemia and other bone
marrow failure syndromes.
One patient presented at age 66 years with MDS with bone
marrow dysplasia and 3 % bone
marrow blasts, and at the time his
sample was obtained he had transformed to refractory anemia with excess of blasts in transformation (RAEB - t) with 25 % bone
marrow blasts; the second patient presented at age 74 years with refractory anemia and 7 % bone
marrow blasts.
Conclusion: When the result obtained for the level of MRD is within 1 log of the cut - off value used for making decisions, variation in the assay and / or
sampling may result in a misleading assessment of the true level of
marrow MRD.
In the process, they set up an approach applicable to future
samples — including an additional set of 1.08 million cord blood, bone
marrow, and white blood cells that the team, in collaboration with Broad Institute Member Nir Hacohen and Alexandra - Chloe Villani, has already processed and will release once all approvals are confirmed.
The methods in this study are novel, she added, «because you can't go around
sampling people's spleen and bone
marrow after they've been bitten by mosquitoes.»
For this look, I used Blue - Eyed Girl Lacquer «s Thrill Me to the
Marrow (pale pink) and Robo - Aggression (gray), Pepper Pot Polish «s The Big Fuzz (peach), and Elevation Polish «s
Sample JY # 26 (glitter).
For this reason, your veterinarian may recommend that a
sample be taken from the bone
marrow.
In some cases, diagnosis may require
sampling of bone
marrow or other organs, tissue biopsy, or molecular testing (flow cytometry, PARR).
In non-regenerative anemias it may be necessary to examine
samples of the blood - forming
marrow of the bones to determine the cause.
Additional testing may include testing of blood and tissue
samples, diagnostic imaging such as ultrasound and radiography, biopsies of masses, internal organs or bone
marrow, and endoscopy including; bronchoscopy (lungs), cystoscopy (bladder & urethra), colonoscopy (colon & small bowel), gastroduodenoscopy (stomach & upper intestines), rhinoscopy (nasal cavity), laparoscopy (minimally invasive surgery for biopsies of internal organs).
Collection of
samples of the bone
marrow tissue are helpful in determining the cause of anemia or other blood cell disorders.
To confirm the diagnosis, a
sample of bone
marrow, obtained by needle aspiration or needle biopsy, may be required to confirm the diagnosis.
Staging may include
sampling lymph nodes, chest radiographs, abdominal radiographs, abdominal ultrasound, CT scan, MRI scan, blood work, special stains, or bone
marrow aspiration.
Extracted DNA from blood, bone
marrow, and cerebrospinal fluid
samples using the QIAamp DNA mini and micro kits
Culture, harvesting and banding of chromosomes from peripheral blood, skin and other tissues, amniotic fluid, chorionic villus
sampling and bone
marrow.