Sentences with phrase «marrow studies»

The same pattern turned up in bone marrow studies.

Not exact matches

Studies have shown that chlorophyll found in food or small purified amounts of chlorophyll have a favorable effect on red blood cell formation in the bone marrow.

A new study explains how a widely used drug is effective against inflammatory bowel disease and rejection of bone marrow transplants, while suggesting another way to address both health issues.

Richard Jones, M.D., professor and director of the Bone Marrow Transplant Program at Johns Hopkins, developed a now commonly used assay to study ALDH levels in individual cells.

In a study published in Nature Communications, the investigators report that hyperglycemic mice (or mice with type 2 diabetes) have a 24-fold higher accumulation of succinate, an intermediate metabolite, in the metabolic pathways of their bone marrow stromal cells.

In the study, «Succinate and its G - protein - coupled receptor stimulate osteoclastogenesis,» the researchers took samples of bone marrow from hyperglycemic male mice and healthy mice.

Results of a Johns Hopkins study may explain why a chemotherapy drug called cyclophosphamide prevents graft - versus - host (GVHD) disease in people who receive bone marrow transplants.

Adding stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength of the newly formed bone, according to a laboratory - based study presented at the European Congress of Endocrinology in Dublin.

The researchers added human bone marrow stem cells from a non-diabetic donor to a bone fracture in laboratory pre-clinical studies.

St. Jude Children's Research Hospital leads study showing that a drug withdrawn from the market in 2010 may enhance the effectiveness of bone marrow transplants for select pediatric leukemia patients

By studying the receptor for thrombopoietin, called Mpl, on blood cells in the bone marrow, the team pinpointed the cells involved in making platelets after thrombopoietin stimulation, and made an unexpected discovery.

Now, the new multi-center study confirms that the post-transplant cyclophosphamide is safe and effective for people who have received fully - matched bone marrow transplants.

Scientists have known about the beneficial effects of bone marrow transplants since the late 1960s, but «there really hasn't been much data available to explain what is going on,» says immunologist James George of the University of Alabama, Birmingham, an author of the new study.

«Bone marrow concentrate improves joint transplants: Study shows treating cartilage grafts before biologic joint replacement speeds healing.»

«No reliable approach is currently available for complete restoration of damaged articular cartilage,» said Dr. Bai - wen Qi, «in this study, CS / PVA gel was combined with rabbit bone marrow stromal cells (BMSCs) transfected with hTGFβ - 1 and used to repair rabbit articular cartilage defects and the repair effect was evaluated.»

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

A few studies showed that stem cells from bone marrow could create scar tissue.

In further studies, the researchers tested the capacity of ANG to prevent and mitigate radiation - induced bone marrow failure, and in pre-clinical models, they found that survival following radiation exposure was increased after treatment with recombinant ANG protein.

Studying mouse monocytes in more detail, the researchers found that the increase in TNF levels that occurs with age causes premature release of immature monocytes from the bone marrow into the blood stream.

Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.

In a different study Waghmare presented at the recent annual meeting of the American Society for Blood and Marrow Transplantation in Orlando, Florida, the researchers teased out a few risk factors that can drive the development of lower respiratory tract infections — namely, high levels of steroid use (commonly given to transplant patients for other complications such as graft - vs.

As part of the new study, researchers deleted CXCL12 production specifically from bone marrow vasculature in leukemic mice.

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

In recent studies of cancer patients who received a bone marrow transplant, genes from the marrow's white blood cells were found in the patient's tumor cells.

The study developed a new in vitro system made from bone marrow stem cells and studied what would happen if its ambient temperature fell below 37 °C (the natural temperature of the human body).

But the study subjects only maintained noticeable levels of the foreign bone marrow for a few weeks, and the protocol didn't work for everybody.

Bone marrow biopsies often produce limited numbers of tumor cells to test — as few as 50,000 tumor cells in this study — but for this technique that is enough to test many different drugs and drug combinations.

The latest study builds off of work Kawai and his colleagues began fourteen years ago, when they launched the first clinical trial that attempted to use bone marrow to induce immune tolerance for kidney recipients, to avoid the sometimes dangerous side effects of life - long immosuppressive therapy.

The study examined nanoparticle entry into endothelial cells and macrophages for the in vitro study, and the same type of cells from the lung, heart and bone marrow for the in vivo component.

«Communication between lung tumors, bones contributes to tumor progression: Study identifying interaction among tumor cells, bone marrow and immune cells opens new avenue for immunotherapy.»

«Our approach represents a different way of looking at leukemia and considers the entire bone marrow as an ecosystem, rather than the traditional approach of studying and trying to directly kill the diseased cells themselves,» said Allison Boyd, postdoctoral fellow with the research institute and first author of the study.

In a study published in the June 12 edition of Science, they detail how a new drug repaired damage to the colon, liver and bone marrow in animal models — even going so far as to save the lives of mice who otherwise would have died in a bone marrow transplantation model.

Nathaniel Rothman of NCI, one of the senior authors of the study, says that although these reductions are modest, they raise the question of what other kinds of changes are taking place in the blood - forming regions of the bone marrow.

The study suggests that attacking those subsets with targeted drugs may degrade the disease's ability to spread throughout the bone marrow of affected patients, the authors say.

This rejuvenated the stem cells in the bone marrow of the older mice that replenish their blood, and led to a wave of studies comparing the blood of old and young mice to try and identify the youth - giving substance.

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

The study revealed that MSCs isolated from the bone marrow of patients with elevated bone marrow metal concentrations had lost the ability to differentiate into bone - forming osteoblasts.

Now, in a study recently published in the journal PLOS ONE, a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of hCMV and the onset of graft - versus - host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant.

In the study, USC Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HSCs.

However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow might affect patients undergoing this risky procedure, frequently used to treat cancer and blood diseases.

Two studies finger bone - marrow defects rather than cells as culprits in blood disorders known as myeloproliferative syndromes

Our previous study showed that microneedle vaccination induced higher levels of antibody - secreting cells in spleen and bone marrow compared to intramuscular vaccination,» says Sang - Moo Kang of Georgia State University, a researcher on the study.

The study enrolled 61 older adults from the University of Michigan and Washington University in St. Louis who were undergoing a reduced - intensity bone marrow transplant with cells donated from a relative.

In this study, the ALS mice were given intravenous treatments of one of three different doses of the bone marrow stem cells.

A new class of drugs reduced the risk of patients contracting a serious and often deadly side effect of lifesaving bone marrow transplant treatments, according to a study from researchers at the University of Michigan Comprehensive Cancer Center.

Results of this study will be presented by David Porter, MD, a professor of Hematology - Oncology and director of Blood and Marrow Transplantation in Penn's Abramson Cancer Center.

For this study, the researchers used data from retrospective HSCT surveys by the Worldwide Network for Blood and Marrow Transplantation.

In the new study, Ildstad and colleagues built on earlier attempts to use bone marrow transplants to help people receiving a new kidney.

ANAHEIM, CALIFORNIA — Chronic myeloid leukemia (CML) cells invade the bone marrow and spleen by destroying healthy cells with a toxic protein, according to a new study.

And the utility of bone marrow cells is becoming increasingly «unclear,» said Chien, especially in light of the ambiguous results of three studies reported last month in the New England Journal of Medicine.