Sentences with phrase «marrow tissue»

Collection of samples of the bone marrow tissue are helpful in determining the cause of anemia or other blood cell disorders.

In conjunction with bone marrow tissue cells, these HSCs form a microenvironment known as a niche.

Subsequent transplant of millions of human T - ALL cells into normal mice that were then treated with an anti-CXCR4 drug induced remission within two weeks, with diseased spleen and bone marrow tissue nearly returning to normal.

In a first step towards creating artificial sperm cells, researchers have turned human bone marrow tissue into primitive sperm cells.

The cells used to build the organs could be cultured from stem cells taken from fat or bone - marrow tissue, he says: «We could engineer a blood vessel from your own cells.»

Using their new model, Jamieson, Crews and team found that two events converge to activate ADAR1 in multiple myeloma — a genetic abnormality and inflammatory cues from the surrounding bone marrow tissue.

Not exact matches

Reserve meat, skin, connective tissues, and marrow to be consumed.

Bone marrow is the sponge - like tissue inside certain bones.

Then, to boost the number of cells, which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with human mesenchymal stem cells from bone marrow.

Bone marrow is the spongy tissue present inside the centre of bones.

Unlike chemotherapy and radiation — which indiscriminately damage cells and tissues, healthy or otherwise — the CD45 - targeting antibodies leave the thymus and the bone marrow, environments critical to the formation of T cells and innate immune cells, unharmed.

Although many scientists doubt that Orlic's bone - marrow stem cells actually morphed directly into new heart tissue, they do believe the cells may have secreted powerful chemical cues — growth factors — or perhaps changed into blood vessels that revitalized the hearts.

A few studies showed that stem cells from bone marrow could create scar tissue.

The researchers used «humanized mice,» which have had their immune systems replaced with human immune system cells, thymus tissue and bone marrow.

A patient's own bone marrow stem cells are, however, a valuable source of potential treatment as they can generate joint tissue the body will not reject when re-implanted.

Within a few weeks, the mesenchymal stem cells have been modified to form cartilage tissue, and within months, the site becomes calcified, forming natural bone containing bone marrow cells.

The disease originates in a lymphoid organ (lymph node, spleen, or bone marrow) before spreading through the blood to infiltrate not only other lymphoid organs but also other tissues.

In experiments in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two weeks.

That makes strontium 90 a particularly dangerous isotope: it can infiltrate milk, bones, bone marrow, blood and other tissues, where the radiation that it emits can eventually cause cancer.

Myelofibrosis is a rare disease of the bone marrow, in which the bone marrow is replaced by connective tissue.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

The team hopes to apply this method to the nerve cells, bone marrow, and brain tissue of living animals and humans.

Stem cells from adult bone marrow normally generate bone, muscle, cartilage and fat cellsa limited set compared with embryonic stem cells, which can spawn the full spectrum of adult tissues.

There is only one exception: the stem cells that are present in the tissues — in the case of blood, the bone marrow.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

These findings may help explain why some people with mutations in certain ribosomal protein genes develop conditions such as Diamond - Blackfan anemia — a blood disorder in which the bone marrow doesn't make enough red blood cells — but don't have problems in other body tissues, Ware says.

The 3 - D tissue - engineered bone marrow (3DTEBM) cultures pictured were developed with bone marrow samples to help determine which treatments are most effective.

Because bone marrow, colon, and liver are significantly different tissues, the investigators believe the pathway by which SW033291 speeds tissue regeneration is likely to work as well for treating diseases of many other tissues of the body.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

In bone marrow transplants, for example, effects of SW033291 in accelerating tissue growth would provide the body the cells required to fight off the two most common and sometimes fatal complications, infection and bleeding.

A patient's own bone marrow stem cells can form bone and cartilaginous tissue, not the underlying vasculature and nerve compartments; and, embryonic stem cell derived bone may prompt an immune rejection.

«Our group pioneered the development of cell culture technology for harvesting large numbers of stem cells from human bone marrow and human umbilical cord blood,» Dr. Yeh said, noting that stem cells from these two sources are abundant and can be guided into different types of cells using tissue engineering.

Now, in a study recently published in the journal PLOS ONE, a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of hCMV and the onset of graft - versus - host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant.

Rodriguez also concludes that including selective facial bone structure in addition to the chin of the donor provided natural bone marrow stem cells to help the transplanted face thrive following the surgery, and provided the necessary positional support for the facial soft tissues.

Professor Anne Dickinson has spent 20 years working to understand how we prevent the body rejecting donor tissue such as bone marrow.

A team led by researchers at the Tufts University School of Engineering and the University of Pavia has reported development of the first three - dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets.

Bone marrow is a soft tissue found in spongy bone tissue.

In this tissue system, we can culture patient - derived megakaryocytes — the bone marrow cells that make platelets — and also endothelial cells, which are found in bone marrow and promote platelet production, to design patient - specific drug administration regimes.»

Weian Zhao, associate professor of pharmaceutical sciences, and colleagues have programmed human bone marrow stem cells to identify the unique physical properties of cancerous tissue.

David Kaplan, Ph.D., professor and Director of the NIH P41 Resource Center on Tissue Engineering, Alessandra Balduini, M.D., and their collaborators have focused on forming bone marrow models with these components and other growth factors to imitate and support the formation of functional human platelets.

Researchers funded by the National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators have successfully developed a 3 - dimensional (3D) tissue - engineered model of bone marrow that can produce functional human platelets outside the body (ex vivo).

Understanding and reproducing key features of bone marrow formation — and hence, the creation of blood cells and platelets in tissue culture for storage and later use — could help in treatment of a variety of medical problems.

Each step of the tissue engineered silk bone marrow development furthered the amount of successful platelet production and allowed the researchers to use a minimal amount of resources while maximizing the output of functional platelets.

To test whether adipose tissue F4 / 80 + cells shared a common bone marrow origin with other tissue macrophage populations, we transplanted bone marrow from C57BL / 6J mice expressing the CD45.1 leukocyte marker into 6 - week - old lethally irradiated C57BL / 6J mice expressing the CD45.2 leukocyte marker.

Tissue macrophages are derived from bone marrow precursors that migrate from the peripheral circulation.

Together these data suggest that the F4 / 80 + cells identified in adipose tissue are CSF - 1 — dependent, bone marrow — derived adipose tissue macrophages.

Our data also suggest that the increased accumulation of macrophages in adipose tissue of the obese is due to an influx of bone marrow — derived precursors into adipose tissue and their subsequent differentiation into mature F4 / 80 - expressing macrophages.

Obesity is accompanied by ectopic lipid deposition in multiple tissues, including the skeleton, where infiltration of adipocytes into the bone marrow niche may negatively impact bone formation (7, 8).

Adipose tissue was collected and SVCs were isolated 6 weeks after lethal irradiation and bone marrow transplantation.

F4 / 80 + cells in adipose tissue are bone marrow — derived.