Sentences with phrase «mast cell surface»
Current studies focus mainly on two receptor systems - the mast cell surface receptor, FcεRI, and the receptor for epidermal growth factor that operate in immunological and cell proliferation responses.
https://www.thevalleefoundation.org/
The researchers utilized a technique known as exon skipping, a form of RNA splicing, to eliminate the portion of one of the IgE receptor gene's mRNA that is essential to making a protein which places the IgE receptor on the mast cell surface.
Left: mast cells are activated by allergens reacting with IgE bound to IgE receptors on the mast cell surface to trigger the release of histamine and other inflammatory mediators that orchestrate an allergic response including recruitment of inflammatory cells.
Which leads to the question — if you're a geneticist anyway — why does anyone have a mechanosensor on their mast cell surfaces?
Not exact matches
The ADGRE2 gene provides instructions for production of ADGRE2 protein, which is present on the surface of several types of immune cells, including mast cells.
S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.
New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.
Right: exon skipping treatment eliminates trafficking of the IgE receptor to the surface of mast cells, rendering the cells unresponsive to allergen - mediated mast cell activation.
«By eliminating the expression of the IgE receptor on the surface of mast cells, we have identified an innovative and targeted approach with the potential to treat allergic inflammation in millions of patients worldwide.
Roles of RabGEF1 / Rabex -5 domains in regulating FcϵRI surface expression and FcϵRI - dependent responses in mast cells.
These antibodies are found on the surface of mast cells.
The IgE allergen complexes bind to the surface of mucosal mast cells and basophils, triggering the localized release of histamine, which results in the symptoms of OAS.28
Once they occur, mast cell tumors can quickly grow from small «skin tag» - like growths on the surface to the skin to invading full thickness of the skin, and progressing to the lymph nodes for systemic infection.