Sentences with phrase «mast cell surface receptor»
Current studies focus mainly on two receptor systems - the mast cell surface receptor, FcεRI, and the receptor for epidermal growth factor that operate in immunological and cell proliferation responses.
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New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.
Right: exon skipping treatment eliminates trafficking of the IgE receptor to the surface of mast cells, rendering the cells unresponsive to allergen - mediated mast cell activation.
Left: mast cells are activated by allergens reacting with IgE bound to IgE receptors on the mast cell surface to trigger the release of histamine and other inflammatory mediators that orchestrate an allergic response including recruitment of inflammatory cells.
«By eliminating the expression of the IgE receptor on the surface of mast cells, we have identified an innovative and targeted approach with the potential to treat allergic inflammation in millions of patients worldwide.
The researchers utilized a technique known as exon skipping, a form of RNA splicing, to eliminate the portion of one of the IgE receptor gene's mRNA that is essential to making a protein which places the IgE receptor on the mast cell surface.