Sentences with phrase «matched donor cells»

Not exact matches

If your twins are fraternal, it is also good to know that most current cord blood treatments require the use of a well matched donor's stem cells, like a sibling's.

That's particularly good news for people of certain ethnic minorities who often have trouble finding matched stem cell transplant donors.

New findings presented today indicate that with proper considerations, haploidentical (half - matched) transplants or transplants using cord blood cells can be viable, effective alternatives when a fully matched donor is not available.

To help the new organ withstand the assault from the recipient's natural defenses, doctors developed tissue type matching, a technique to determine if the chemistry of the donor's immune system, defined by antigens on the surface of cells, was similar to that of the recipient's.

Historically, clinicians evaluating a patient for transplant have sought to identify donor cells that are perfectly matched to the patient's cell type, which is considered to be the optimal approach to help ensure successful outcomes and to minimize risk of graft - versus - host disease (GVHD), a serious and potentially life - threatening complication that occurs when the donated immune cells attack the patient's cells as foreign tissue.

In Western society the population is growing older, the incidence of chronic disabilities which could be treated by stem cell therapy is steadily rising, and the availability of donor organs is not matching the need.

The American Red Cross and the researchers themselves were quick to say the study is not definitive enough to change the current practice of matching red blood cell donors to recipients.

Researchers have long used a different monkey species to research stem cell transplants, but that species» biological characteristics means it can't be reliably used to find good donor matches to mimic human stem transplants.

Organ transplantation is a challenge, requiring immunosuppressive drugs and careful matching of donor and recipient for human leukocyte antigen markers, receptors on immune cells that recognize foreign proteins.

This approach also does not rely on the identification of a matched donor, thus avoiding the risk of rejection of donor cells.

Even more remarkable was that each stem cell line genetically matched one of 11 skin cell donors.

In these therapies, the patient's own blood - producing bone marrow cells are treated with radiation and chemotherapy, and the blood of a twin or closely matched donor is instilled.

As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.

It comes as a surprise to many patients in need of a stem cell transplant that approximately 70 % of patients do not have a matching donor in their family.

Ultimate use of newborn stem cells will be determined by the treating physician who will consider if they are applicable for the condition and should come from the patient or a suitable donor (siblings of the same biological parents have a 25 % chance of being a perfect match and a 50 % chance of being a partial match; biological parents will always be a partial match).

Then bone marrow stem cells from an immunologically matched donor (or from the patient's own body) are given back to the patient.

Patients transplanted with cells from a parent or an unrelated donor do not do as well as those receiving fully matched transplants.

Patients receive one of two types of stem cell - based transplants: autologous, in which a patient donates and receives back his / her own stem cells; or allogeneic, in which bone marrow - derived stem cells come from a related or unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those of a patient.

The ability to safely use half - matching donors (parents, most siblings, and all children of the patient) makes bone marrow transplant an effective option for the majority of sickle cell patients.

By typing for HL - A antigens, donors and recipients of white blood cells, platelets, and organs can be «matched» insuring good performance and survival of transfused and transplanted cells.

What are appropriate sources of stem cells for HCT in patients without an HLA - matched, related donor?

The best treatments include blood transfusions or bone marrow transplants from a matched donor, but this is limited due to the eventual immune response which is mounted against the donated cells.

Using a combination of half - match stem cells from a related donor and cord blood stem cells, haplo - cord transplant opens the option of transplantation to nearly all patients for whom the procedure was previously not available.

For that to be done successfully, a bone marrow donor match has to be found, and then chemotherapy given, before a person with the disease is ready to have donor bone marrow cells transplanted.

Matching of MHC alleles between the donor and recipient is important for the success of stem cell and tissue transplants.