Maternal age effect and severe germ - line bottleneck in the inheritance of human mitochondrial DNA.
Maternal age effect and severe germ - line bottleneck in the inheritance of human mitochondrial DNA Rebolledo - Jaramillo, B., M. S. Su, N. Stoler, J. A. McElhoe et al. 2014.
Knowledge about both
the maternal age effect and the bottleneck size is useful in family planning.
Results also seemed to indicate that
the maternal age effect is stronger than the paternal age effect.
The discovery of a «
maternal age effect» by a team of Penn State scientists that could be used to predict the accumulation of mitochondrial DNA mutations in maternal egg cells — and the transmission of these mutations to children — could provide valuable insights for genetic counseling.
Not exact matches
On the other hand, advanced
maternal age is associated with a more stable family environment, higher socio - economic position, higher income and better living conditions, as well as better parenting practices, [14] but it is more or less uncertain whether these entities are
effects of advanced
maternal age, are contributors to advanced
maternal age, or common
effects of a certain state such as personality type.
The
effect of advanced
maternal age upon human milk fat content.
Combined
effects of
maternal age and parity on successful initiation of exclusive breastfeeding.
Of note, our models may underestimate the true
maternal costs of suboptimal breastfeeding; we modeled the
effects of lactation on only five
maternal health conditions despite data linking lactation with other
maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before
age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's
effect on both diabetes and MI.
The
effect of
maternal age and planned place of birth on intrapartum outcomes in healthy women with straightforward pregnancies: secondary analysis of the Birthplace national prospective cohort study
Our data agrees with that of others, 1223 that suggest that delaying the introduction of formula milk protects against the morbidity associated with respiratory infection, illness, and associated hospitalisations in the first year of life.24 Prolonged breast feeding was only marginally associated with less respiratory illness when examined in a New Zealand birth cohort to 2 years of
age, 25 and the Dundee study8 showed a small, yet significant protective
effect of breast feeding against respiratory illness at 0 — 13 weeks and 40 — 52 weeks after adjustment for social class,
maternal age, and parental smoking.
The addition of the Infant Feeding Intentions score to the model strengthened the association with
maternal age and BMI, with little
effect on the other variables.
We found little evidence that between - study heterogeneity in estimates was explained by
age at measurement of blood pressure (p = 0.5), decade of birth (p = 0.2), stipulation of a minimum duration of breastfeeding (p = 0.5), proportion of the target population in the main analysis (p = 0.2), whether breastfeeding was exclusive for at least 2 months (p = 0.2), method of blood pressure measurement (p = 0.4), or whether
effect estimates controlled for socioeconomic factors (p = 0.9),
maternal factors in pregnancy (p = 0.9), or current weight (p = 0.9).
Ozanne says that similar
ageing effects have been identified in beta cells from people with type 2 diabetes, but she adds that her team have yet to prove this is linked to poor
maternal diet in humans.
The study could not absolutely rule out some
effect of older mothers, but «we're pretty confident that the paternal
age risk holds no matter what the
maternal age,» he says.
While previous studies have demonstrated the
effects of
maternal depression on children's limited response to other's pain, this new study is the first to examine this topic in a longitudinal sample of mother - child pairs followed from birth to
age 11.
We investigated the
effects of treatment of
maternal hypoxic pregnancies with an antioxidant on the cardiovascular system of the offspring at two stages of life: in the fetal period at the end of gestation and at 4 months of adult
age.
Though western medicine tends to write off these patients as a lost cause with «advanced
maternal age,» with consistent treatment OM techniques can help to reverse the
effects of
aging and increase the likelihood of successful conception and healthy pregnancy.
The
effect of
maternal care and
age of separation (from the mother) on TC was also evaluated using a generalized linear model with a binomial distribution.
Black race was associated with teaching / verbal assertion and mild physical force, and race was part of an interactive
effect with
maternal age for limit setting.
Logistic regression analyses were conducted to estimate the
effect of
maternal IPV on asthma diagnosed by
age 36 months while adjusting for potential confounders (child's sex,
age, race / ethnicity, low birth weight,
maternal education, economic hardship, and tobacco exposure).
Based on prior empirical and theoretical work, this study investigated the following hypotheses: (1)
maternal exposure to IPV will be associated with higher odds of obesity at
age 5 years in their children; (2)
maternal exposure to IPV will be associated with feeding practices and behaviors that elevate risk for childhood obesity; and (3)
maternal perception of lower neighborhood safety will increase the
effect of IPV on childhood obesity risk.
It is also possible that the relatively small
effect of
maternal feeding behaviors is overwhelmed by cofounders such as television viewing or consumption of calorically dense foods (eg, sweets or French fries), which are, like
maternal feeding behaviors, associated with both markers of socioeconomic status (58, 59) and adiposity (58, 60) and an increase in frequency between
ages 15 and 36 mo (61, 62).
Detailed
maternal report on delivery allowed us to look at the
effects across the continuum of gestational
age.
Maternal age at delivery, ethnicity, smoking during pregnancy, parity, paternal diabetes status at follow - up, family social class, sex, offspring physical activity, and offspring smoking habits were not found to be confounders and had no
effect on offspring risk of type 2 diabetes / pre-diabetes when entered in multiple logistic regression models.
The results in Tables 2 and 3 also indicate that concurrent risks (most consistently
maternal depression and stressful life events) and
maternal life history risks (most consistently giving birth before
age 20 and leaving home before 18 years of
age) exerted a consistent and generalized
effect on children's health outcomes at 2 years of
age.
For low - income families headed by single mothers, the associations between
maternal employment and children's cognitive and social development tend to be neutral or positive, but much of this difference is a function of pre-existing differences between mothers who are or are not employed.2, 3,4,5 The
effects of
maternal employment on children's development also depend on the characteristics of employment — its quality, extent and timing — and on the child's
age.2, 6,7 On the other hand, poverty has consistently negative associations with young children's development, but here, too, there is considerable controversy about the causal role of income per se, as opposed to other correlates of poverty.8, 9,10,11,12,13
Contrary to meta - analytic findings of the earlier literature that focused only on the
effects of the amount of care provided without adequately controlling for selection
effects, the NICHD Study found that a number of features of child care (the amount of child care,
age of entry into care, and the quality and stability of child care) were unrelated to the security of infant — mother attachments or to an increased likelihood of avoidant attachments, except when mothers provided less sensitive parenting of their infant.11 For the children who received less sensitive
maternal care, extended experience with child care, lower - quality child care, and more changes in child care arrangements were each associated with an increased likelihood of developing an insecure attachment with their mothers.
For the upper - bound
effects on
maternal employment, we estimated what the increase in
maternal employment for children with children under
age 6 required to reach the higher level of overall
maternal employment for mothers with children
ages 6 through 17 (with none younger than 6 years old).
The most recent follow - up study reported associations between duration of breastfeeding and childhood cognitive ability and academic achievement extending from 8 to 18 years in a New Zealand cohort of 1000 children.19 This study found that these
effects were significant after controlling for measures of social and family history, including
maternal age, education, SES, marital status, smoking during pregnancy, family living conditions, and family income, and measures of perinatal factors, including gender, birth weight, child's estimated gestational
age, and birth order in the family.
Results showed intervention
effects for early externalizing and internalizing problems from 2 to 4, and reductions in
maternal depression from
ages 2 to 3.
A recent study found that as little as a half - day per week in formal child care at
age two buffered the
effects of recurrent
maternal depression on children's behavior problems at
age five.
Prenatal
effects of selective serotonin reuptake inhibitors antidepressents, serotonin transporter promoter genotype (SLC6A4), and
maternal mood on child behavior at 3 years of
age.
Inhibitory control moderated the
effect of profile membership on girls» BMI at
age 7 (ANCOVA: F [165,3] = 3.28, P < 0.05), after adjustment for girls» BMI at
age 5 y,
maternal education, and BMI and family income.
Inhibitory control moderated the
effect of profile membership on girls» EAH at
age 7 y (ANCOVA: F [155,3] = 2.06, P < 0.10), after adjustment for girls» EAH at
age 5 y,
maternal education, and BMI and family income.
After adjusting for the duration and severity of
maternal depression, duration of treatment, number of depressive episodes after delivery,
maternal IQ and socioeconomic status, the study showed that tricyclic antidepressants and fluoxetine had no adverse
effects on the global IQ, language development or behaviour of children between 15 and 71 months of
age [60].
Patterns of attachment and
maternal discourse
effects on children's emotion understanding from 3 to 5 years of
age.
This study investigated joint
effects of
maternal prenatal smoking and parental history of antisocial behavior on physical aggression between
ages 17 and 42 months in a population sample of children born in Québec (N = 1,745).
Assessments of cognitive and socioemotional competence at 4 years and kindergarten
age suggested a protective
effect of secure infant attachment but little benefit from secure preschool attachment.This study was supported by Grants MCJ - 540615 and R40 MC 00091 from the
Maternal and Child Health Bureau (Title V, Social Security Act), Health Resources and Services Administration, Department of Health and Human Services and by Grant MH48395 from the National Institute of Mental Health, Department of Health and Human Services.