Vitamin K2 activates the calcium - binding activity of two proteins called
Matrix gla protein and osteocalcin, which help to build and maintain bones (13, 14).
Vitamin K and vitamin D work to increase a substance called
Matrix GLA protein (MGP).
Vitamin K2 is an essential micronutrient that acts as a cofactor for the γ - carboxylation of glutamic residues in a number of proteins, including
matrix Gla protein (MGP), which, when activated, prevents the calcification of blood vessels (21).
Adequate intake of vitamin K2 - 7 has shown to lower the risk of vascular damage because it activates what is called
matrix GLA protein (MGP).
MK - 4 has a host of benefits, including keeping calcium out of soft tissues by activating a Vitamin K - dependent protein,
matrix Gla protein (MGP).
Mice lacking
matrix Gla protein (MGP), a vitamin K - dependent protein that guards against arterial calcification, develop heavily calcified aortas and die prematurely.
Matrix Gla - protein (MGP) helps to prevent vascular calcification by pulling calcium out of soft tissues, while activated osteocalcin pulls calcium back into the bones and teeth.
In the past few decades, scientists have realized that vitamin K2, menaquinone, is largely responsible for activating vitamin K - dependent proteins (VKDPs), such as osteocalcin and
matrix Gla - protein.
Human research is still in the early stages, but we know that Vitamin K is needed for the production of MGP (
matrix GLA protein), which helps avoid calcification in the arteries.
Matrix Gla - protein (MGP) helps to prevent vascular calcification by pulling calcium out of soft tissues, including arteries and veins.
Matrix Gla protein regulates calcification of the aortic valve.
Like
matrix Gla protein, vitamin K is essential to increased production of osteocalcin, a protein hormone important to bone metabolism and insulin sensitivity.
For example, one direct, negative impact of low vitamin K intake on the heart may be reduced activity of
matrix Gla protein, which helps prevent calcium deposits on blood vessel walls.
Not exact matches
However, in order to have these many effects in the body, osteocalcin must be activated to its carboxylated form by vitamin K - dependent proteins, known as
matrix -
GLA proteins, or MGPs.
By expressing
Matrix -
GLA protein locally in the cartilage, correction of the facial growth was also achieved.