Sentences with phrase «measure cell response»

Despite having been vaccinated against the disease in 1989, which was 3 years before Sousa and her colleagues examined them, 58 % of the Indians had a weakened or nonexistent immune reaction in skin tests that measure cell response to the tuberculosis bacterium.

Not exact matches

Eventually, Lim hopes that reprogrammed cells will measure glucose levels in the pancreases of diabetics and trigger a biological insulin response, or even cure cancer.

It has been particularly difficult to measure changes in electrical functions of cells grown within Organ Chips that are normally electrically active, such as neuronal cells in the brain or beating heart cells, both during their differentiation and in response to drugs.

To check how desensitized the cells had become, they measured the cells» response to acetylcholine.

Building on the newly - published pilot study, the team will conduct experiments using a windtunnel which measures the behaviour of mosquitoes towards odours and electrodes which track the response of individual odour - detecting cells from within the antenna of the mosquito in specially - designed secure laboratories at the School to measure the responses of malaria - infected Anopheles gambiae s.s. females to human odours.

Crotty says the ability to measure Tfh cells in the blood will assist AIDS vaccine researchers by serving as an indicator of antibody response.

The test also measures the responses of all the individual cells in the organoid.

Using a technique that measures the response of the olfactory system to odours, the researchers showed that copper and nickel affect the ability of different cells to detect odours.

The researchers measured tail response learning to electric shock to determine patterns of aging in both the nerve cell that senses touch of the tail, called sensory neurons, and the motor neurons that signal the tail muscle to contract.

In addition to monitoring the response of injected melanoma tumors, we are also measuring the boost in the anti-tumor immune cells of patients after injection,» explained Amod A. Sarnaik, M.D., assistant member of Moffitt's Cutaneous Oncology Program.

To investigate that response in the context of HIV, the study grouped women by their CD4 cell count, a measure of immune system health.

The results, published in tomorrow's issue of Cell, might also lead to new measures for preventing gray hair by modulating the DNA damage response.

Researchers compared the inflammatory response of control - treated versus simvastatin - treated cells to RV by measuring CXCL10 secretion, an implicated therapeutic target for virus - induced asthma exacerbations.

Immediately after the subjects viewed the slide shows, researchers drew their blood, exposed each sample to bacteria and then measured the levels of a substance known as interleukin - 6 (IL - 6), which is secreted by white blood cells as a response to stress or trauma.

Immune cells called microglia activate as part of the body's inflammatory response, so the researchers used a brain imaging technique to measure a substance that increases in activated microglia.

«We were able to develop this very novel method to go to a single neuron and manipulate how it computes» by using drugs to block neurotransmitters at the level of a single nerve cell in a frog brain, and then measuring what happens to that neuron in response to frog calls, Alluri says.

In future, it may be possible to measure BCR - ABL levels in individual cells in the clinic — this will help us identify the resistant high BCR - ABL cells and better understand how patients develop resistance to imatinib treatment with the aim of combatting this resistance to make response more durable and the treatment more effective.»

After measuring millivolt changes in 58 brain cells in frogs in response to sound, the researchers used a mathematical model to convert the information into how much a brain cell was excited or inhibited by a given sound pulse.

The protocol can be used to measure adaptive responses following the stimulation of whole blood samples or purified peripheral blood mononuclear cells (PBMCs) and includes a freezing step that allows the stimulated samples to be shipped from the collection site to the analysis facility.

This will include testing the mechanism of action of different adjuvant and antigen formulations by measuring B - and T - cell responses and by using various functional assays (ELISA, FACS, cytokine profiles), transcriptomics and / or proteomics.

In Vivo Adipogenesis in Rats Measured by Cell Kinetics in Adipocytes and Plastic - Adherent Stroma - Vascular Cells in Response to High - Fat Diet and Thiazolidinedione.

Responses were correlated to calcium release in cultured rat uterine smooth muscle cells measured by fluorescence microscopy.

Importantly, splenic titers of LCMV measured on day 7 postinfection are unchanged by immunization, indicating that despite functional enhancement in the CD8 T cell immune response, the virus is still not cleared by perforin - deficient mice that have been immunized (Fig. 2E).

Live cell assays constructed with genetically encoded, fluorescent biosensors can provide significant advantages over endpoint assays measured in cell lysates because functional information about the timing and location of cellular responses can be monitored in cells that are relevant to disease.

Another team reported that the LINCS approach of measuring a wide range of cells» responses to drugs was more accurate than conventional drug - potency tests.

A cytogenetic response is the measure of the reversion of white blood cells to normal function.

Using single - cell DNA and RNA sequencing, his team performed a detailed analysis of eight clonal persistent patients, measuring miniscule portions of DNA and RNA and found responses to NAC were pre-existing, thus adaptively selected.

LINCS researchers then will measure the cells» tiniest molecular and biochemical responses, and use computer analyses to uncover common patterns in these responses - called «signatures.»

To study the effect of ageing on the ability of CMV - specific CD8 (+) T cells to produce type 1 - and type 2 - cytokines, interferon - gamma - and IL -10-producing, CD8 (+) T cell responses in the presence of CMV peptide antigen were measured in CMV - seropositive old and young donors.

Measuring these residual leukemic cells can be a powerful tool for measuring treatment response, guiding treatment decisions, monitoring remission status, and detecting disease reMeasuring these residual leukemic cells can be a powerful tool for measuring treatment response, guiding treatment decisions, monitoring remission status, and detecting disease remeasuring treatment response, guiding treatment decisions, monitoring remission status, and detecting disease recurrence.

For elucidating the unfolded protein response, a cellular quality - control system that detects disease - causing unfolded proteins and directs cells to take corrective measures.

Response: We originally used the DAB method to determine SNpc cell counts, and once we determined that there were no differences we sought to measure astrogliosis, which required fluorescence detection of both TH and GFAP.

The test measures the activity of genes that control cell growth, and others that indicate a likely response to hormone therapy treatment.

Importantly, cisplatin toxicity and Pgp efflux transporter activity measured on - chip more closely mimic the in vivo responses than results obtained with cells maintained under conventional culture conditions.

Many of the studies which demonstrate the effectiveness of ice baths in reducing inflammation and accumulation of white blood cells (the guys responsible for destroying damaged tissue and creating signals for re-growth) measure this response over a very short time frame - for hours or a couple of days at best.

I recently learned about a newer more reliable test that measures Cell Mediator Responses called LEAP.

It measures the inflammatory response and subtle changes in our immune cells (lymphocytes, neutrophils, monocytes, and eosinophils) as they release chemical mediators (a substance released from cells, e.g., cytokines, histamine, leukotrienes, prostaglandins, etc.), that regulate or cause physiologic consequences during an immune response to an antigen.

Melanopsin cells in mammals are specialized for measuring ambient illumination, contributing to visual discrimination [8,9], and driving a wide variety of physiological responses including, but not restricted to: synchronization of circadian clocks to light: dark cycles, regulation of pupil size, modulation of sleep and suppression of pineal melatonin production [10 — 14].