Since in this study the animals were continuously exposed to nicotine vapor over 90 min and the T1 / 2 of cotinine in C57BL / 6 mice is 37.5 min, the cotinine level (267ng / mL)
measured after the termination of nicotine did not reach steady - state (CotSS).
Objective: We evaluated whether a 12 - wk dietary behavior modification (D) treatment to decrease energy intake, physical exercise behavior modification (E) treatment to implement moderate aerobic exercise, or combined dietary and physical exercise behavior modification (DE) treatment compared with control (usual care)(C) reduces body weight in lactating women
measured at the end of treatment and at a 1 - y follow - up 9 mo
after treatment
termination.