Anticancer activities of anthelminthics were reported for
mebendazole by Mukhopadhyay et al. in 2002, for pyrvinium pamoate (PPAM) by Esumi et al. in 2004 and for niclosamide by Wang et al. in 2009, respectively [8 - 10].
Not exact matches
Correspondingly, the in vivo growth of hedgehog - dependent medulloblastoma was inhibited
by orally administered
mebendazole.
Nygren P, Larsson R. Drug repositioning from bench to bedside: tumour remission
by the antihelmintic drug
mebendazole in refractory metastatic colon cancer.
Treatment of lung cancer cell lines with
mebendazole caused mitotic arrest
by depolymerization of tubulin, followed
by apoptotic cell death.
The existing therapies that will be combined in the METRICS study are metformin, statins, doxycycline,
mebendazole and ibuprofen, but it was
by no means a straightforward process to land on these particular medicines.