Not exact matches
In a previous paper published in ecancermedicalscience, the ReDO researchers examined the anti-cancer properties of the drug
mebendazole, an over-the-counter treatment currently used
for threadworm.
Janssen GPH will also prioritise work with the International Partnership
for Microbicides developing the investigational drug dapivirine
for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs
for Neglected Diseases initiative
for the preclinical research of a reformulated form of flubendazole
for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (
mebendazole) that will facilitate treatment of intestinal worms in younger children.
Dosing of
mebendazole of 30 - 87 mg / kg / day in humans resulted in plasma levels of 120 -218 nM (260 nM
for continuous administration) with coefficients of variation ranging from 27 to 72 %.
In human cells,
mebendazole suppressed the formation of the primary cilium, a microtubule - based organelle that functions as a signaling hub
for Hh pathway activation.
Anticancer activities of anthelminthics were reported
for mebendazole by Mukhopadhyay et al. in 2002,
for pyrvinium pamoate (PPAM) by Esumi et al. in 2004 and
for niclosamide by Wang et al. in 2009, respectively [8 - 10].