Sentences with phrase «mebendazole in»

The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma.

Oral administration of mebendazole in mice elicited a strong antitumor effect in a subcutaneous model and reduced lesions in experimentally induced lung metastasis without any toxicity when compared with paclitaxel - treated mice [9,20].

Nygren P, Larsson R. Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer.

Not exact matches

In a previous paper published in ecancermedicalscience, the ReDO researchers examined the anti-cancer properties of the drug mebendazole, an over-the-counter treatment currently used for threadworIn a previous paper published in ecancermedicalscience, the ReDO researchers examined the anti-cancer properties of the drug mebendazole, an over-the-counter treatment currently used for threadworin ecancermedicalscience, the ReDO researchers examined the anti-cancer properties of the drug mebendazole, an over-the-counter treatment currently used for threadworm.

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts.

Correspondingly, the in vivo growth of hedgehog - dependent medulloblastoma was inhibited by orally administered mebendazole.

Dosing of mebendazole of 30 - 87 mg / kg / day in humans resulted in plasma levels of 120 -218 nM (260 nM for continuous administration) with coefficients of variation ranging from 27 to 72 %.

In human cells, mebendazole suppressed the formation of the primary cilium, a microtubule - based organelle that functions as a signaling hub for Hh pathway activation.

The benzamidazole mebendazole significantly inhibited growth of adrenocortical carcinoma cells, both in vitro and in vivo, the effects being due to induction of apoptosis [19].

The anthelmintic drug mebendazole inhibits growth, migration and invasion in gastric cancer cell model.

Anticancer activities of anthelminthics were reported for mebendazole by Mukhopadhyay et al. in 2002, for pyrvinium pamoate (PPAM) by Esumi et al. in 2004 and for niclosamide by Wang et al. in 2009, respectively [8 - 10].

Examples of drugs identified as high - potential agents within the Repurposing Drugs in Oncology (ReDO) project include mebendazole, cimetidine, nitroglycerin, diclofenac and clarithromycin, among others [3].

Moreover, mebendazole inhibited invasion and migration of cancer cells in vitro, and formation of metastases in vivo in experimental animals.

The existing therapies that will be combined in the METRICS study are metformin, statins, doxycycline, mebendazole and ibuprofen, but it was by no means a straightforward process to land on these particular medicines.

In the conventional world of medicine, one of the mainstays is mebendazole.