«Knowing how cells respond to
mechanical cues in the living embryo and how they physically sculpt tissues and organs in the 3D space will transform the way we think about developmental processes,» said Otger Campàs, a professor in the Department of Mechanical Engineering at UCSB and senior author on the paper that reports this novel technique in Nature Methods.
Not exact matches
By fiddling with the cytoskeletons of real - life hydras, researchers found that the pond polyps rely on
mechanical forces as well as molecular
cues to regenerate head and tentacles
in the right places (SN: 3/4/17, p. 19).
«How bacteria maintain and recover their shape:
Mechanical stress may
cue shape recovery
in bacteria.»
An external
cue — possibly a drop
in air pressure — triggers the ejection of pioneer spores, causing
mechanical changes
in the surrounding tissue that trigger more ejections.
«It's been well established
in the plant field that
mechanical cues can bias plant growth.
Scientists have focused for decades on the role of biochemical
cues in embryonic development, Campàs said, because no techniques existed to measure the
mechanical cues that cells are exposed to during the formation of tissues and organs.
«However, we have little knowledge of how bacteria read out
mechanical stimuli and how they change their behavior
in response to these
cues,» says Jenal.
Leveraging the phylogenetic position of Cnidaria and the accessibility of Nematostella tentacle tubes to optical observation and experimental manipulation (see Video 2), we will define the biochemical and
mechanical cues that drive the morphogenesis of epithelial tubes
in a broad evolutionary context.
In a second step, the female integrates sensory information from chemostimulatory and chemodeterrent
cues, together with other chemical (e.g., pH, alkalinity) and
mechanical cues (7), to resolve whether the water container represents a suitable oviposition site.