Sentences with phrase «mechanical microenvironment»

«Then people discovered that physical forces and mechanical events actually can be upstream of genetic events — that cells are very aware of their mechanical microenvironments.»

Not exact matches

One team of researchers from Vanderbilt University aims to unlock how irradiation might alter the mechanical properties of the microenvironment.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

Blood, air, and nutrient media can be flown through the chips, and mechanical forces can be applied to them, recreating the microenvironment and dynamic state that cells experience inside the body.

Nanostructured and chemically functionalized materials which mimic architectural and mechanical features of natural cell microenvironments hold promise for a better understanding and control of cell physiological processes through molecular and nanoscale interactions.

The Chips are cultured under continuous flow within engineered 3D microenvironments that go beyond conventional 3D in vitro models by recapitulating in vivo intercellular interactions, spatiotemporal gradients, vascular perfusion, and mechanical forces — all key drivers of cell architecture, differentiated function, and gene expression.

Finally, in collaboration with physicists from the Institute Curie, we are also investigating if, in addition to cellular and biochemical tumor microenvironment, mechanical pressure imposed by stroma can stimulate invasion of cancer cells.

These findings suggest mechanical forces in the early embryo's microenvironment may play a bigger role in its development than scientists had realized.