Sentences with phrase «mechanism by»

«ALDH inhibition appears to be an important mechanism by which these environmental toxins contribute to Parkinson's pathogenesis, especially in genetically vulnerable individuals,» said study author Beate Ritz, a professor of epidemiology at the Fielding School of Public Health at UCLA.

If they could make sense of the chaos, they could unravel the mechanism by which life might be cooked up.

Co-author of the paper, Anne Ephrussi said: «While we've known Oskar's genetic role in development for some time, we've not known the mechanism by which this takes place.

Exposure to a group of common pesticides, called dithiocarbamates, has long been associated with an increased risk of Parkinson's disease, although the mechanism by which the compounds exert their toxicity on the brain has not been completely understood.

Dr Robson Gutierre from the Federal University of São Paulo said: «The ability this species has to break down its natural defences could also provide insight into immunity tolerance, a mechanism by which the liver can minimise unwanted inflammations.

AF - 219 is a selective, non-narcotic and orally administered agent that targets the mechanism by which certain nerve fibers become hyper - sensitized and lead to chronic and debilitating symptoms such as cough.

«We wanted to understand the mechanism by which the brain circuit operates,» explained senior author Assistant Professor Shawn Je, from the Neuroscience and Behavioural Disorders Programme at Duke - NUS.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

Her real breakthrough is finding the mechanism by which molecules on Europa's surface could unite with water and energy in the lakes, and maybe even in the vast, deeper ocean.

While the mechanism by which a significant weight loss can reduce asthma - associated risks is unknown, studies have linked obesity to increased inflammation, higher prevalence of gastroesophageal reflux disease, and physical changes in the airway — all of which could contribute to asthma severity.

Acceleration of aging may actually be part of the mechanism by which degenerative disease disrupts the structure and function of the brain,» said Dr. Giniger.

A team of researchers led by Carnegie's Ute Armbruster and Martin Jonikas revealed a mechanism by which plants maintain high photosynthetic efficiency in fluctuating light.

Strahl and Jha said they still don't know the exact mechanism by which Set2 becomes mutated or why its mutation affects its function.

By correlating the flux of chemical sediments and organisms with the passage of eddies, researchers say they have identified a new mechanism by which vent products are transported around the world.

A research group lead by University of Tsukuba Faculty of Life and Environmental Sciences International Tenure Track Assistant Professor Norio Takeshita (who holds a concurrent post as Group Leader of the Karlsruhe Institute of Technology Department of Applied Microbiology) has succeeded in using a super-resolution microscope to visualize the mechanism by which cell polarity is maintained.

A new study just published in the journal Glia and available online on July 11th, details the newly discovered mechanism by which astrocytes are involved in inhibitory synapse formation and presents strong evidence that Transforming Growth Factor Beta 1 (TGF β1), a protein produced by many cell types (including astrocytes) is a key player in this process.

Mark Finney, who is a researcher at the Rocky Mountain Research Station in Missoula, Mont., has been studying flame dynamics at the Missoula Fire Sciences Laboratory to uncover the mechanism by which wildfires spread.

In a study published in EPJ D, Katrine Aalbæk Jepsen from the University of Southern Denmark, in Odense, and her colleague Ilia Solov «yov pinpoint the mechanism by which repair enzymes bind to the damaged site.

One of the ways this problem could be addressed is by establishing a way / mechanism by which scientists could easily exchange materials.

Until now the mechanism by which each cell takes part in ordered collective movement, in particular what kind of information is used by cells to determine the direction of collective cell movements, has not been well understood.

One suggestion was a mechanism by which grant income could be pooled to provide for the future of all contract researchers within a department, or indeed a university.

Molecular recognition is fundamental to transcriptional regulation, the primary mechanism by which cells control gene expression.

The way epigenetics helps understand that process is that it provides the mechanism by which maternal experience of a pup can essentially produce lifelong changes in the brain because many epigenetic changes are that stable.

In 2012 and 2013, Lacy and her colleagues reported the mechanism by which toxin B kills cells.

While the biological mechanism by which exposure to pollution causes lower birth weights are not fully understood, the scientists speculate that several factors could play a role, including maternal inflammation, altered placental function, and reduced nutrient delivery to the fetus, which may impede fetal growth.

Dr de Moor will investigate whether cordycepin acts on the knee joint or on the nerves that relay painful messages from the knee to the spinal cord, and the mechanism by which cordycepin inhibits pain.

The study published in Cell Metabolism reports a mechanism by which two types of brain cells, neurons and glia, normally support each other's functions.

At the time, the mechanism by which the plaques were being removed was not clear.

The Penn team analyzed and integrated massive datasets of DNA sequences, which facilitated the discovery of the mechanism by which HDAC3 acts as the brown fat pilot light.

I say that's understandable because there's a very clear behavioral mechanism by which that can occur.

The neural mechanism by which synesthetic colors are automatically bound to alphanumeric characters remains a mystery.

«The precise mechanism by which the corona overlying the solar surface is heated to temperatures of one to two million kelvins remains one of the outstanding problems of solar physics.

A key finding was the mechanism by which Id4 silences matrix metalloproteinase 2 (MMP2), determined to be inhibition of the protein Twist1 that is required for MMP2 expression.

The UK researchers set out to investigate the mechanism by which the treatment may act in the brain to lower amyloid deposition (amyloid deposits being a key pathology in Alzheimer's).

The findings, presented by Víctor González - Motos of Hannover Medical School, Germany, and colleagues, may provide new insight into the poorly understood mechanism by which VZV spreads after initial infection in the respiratory tract.

The faculty hopes to drive its reforms still further in the future through a mechanism by which the individual institutes compete for a portion their faculty funding.

They also encourage future studies to uncover the precise mechanism by which aspirin blocks HMGB1.

«This research therefore outlines a plausible mechanism by which molecules present in interstellar space, brought to earth by meteorite strikes, could potentially be converted into 2 - deoxy - D - ribose, a molecule vital for all living systems.»

«Identification of the mechanism by which cells interact with their milieu.»

Just as flu season swings into full gear, researchers from the University of Colorado Boulder and University of Texas at Austin have uncovered a previously unknown mechanism by which the human immune system tries to battle the influenza A virus.

Eye and Ear researchers set out to understand if both types of hearing loss share a common underlying mechanism by studying certain inbred strain of mice.

«While symptoms can be severe or even debilitating, the mechanism by which Giardia infection causes the disease symptoms remains unclear,» said Dawson.

The finding that plant seeds can be pre-colonized may be an important mechanism by which a beneficial plant microbiome is established and sustained.

But this is in fact a significant issue in the mechanism by which study sections can protect their sub-field from «intruders», particularly when the subject matter is unfamiliar to many members of the study section.

«In time, knowledge of the mechanism by which KIF1B - β induce cell death might prove important in attempts to develop new neuroblastoma therapies.»

The exact mechanism by which RNA transmits the spotting trait to progeny in the absence of the gene that causes spotting in the parent remains mysterious.

They point to the need for further studies to compare gabapentin to more traditional antiemetic drugs, as well as to understand «the actual mechanism by which gabapentin preempts nausea and vomiting.»

Having a mass of only less than seven per cent of the mass of the Sun, they are unable to create sufficient pressure and heat in their interiors to ignite hydrogen - to - helium fusion, a fundamental physical mechanism by which stars generate radiation.

«The mechanism by which empowering leadership encourages proactivity has also not been studied in detail.»

In addition to TDA's killing mechanism, the researchers were interested in understanding the mechanism by which a bacterial strain could become resistant to the antibiotic.