Sentences with phrase «mechanism for all disease»

«If indeed this turns out to be one of the main mechanisms for disease, we now have a whole host of diagnostic and therapeutic techniques that we didn't have before.»

«Pin1 changes protein shape through proline - directed phosphorylation, which is a major control mechanism for disease,» explains co-senior author Kun Ping Lu, MD, PhD, Director of Translational Therapeutics in the Cancer Research Institute at BIDMC and Professor of Medicine at Harvard Medical School who co-discovered the enzyme in 1996.

Where research uncovers possible mechanisms for disease, those working in drug discovery can use these data to develop novel diagnostic or monitoring tools, to develop therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing — therapies are targeted at the correct subgroup of patients.

«We are both physicians who emphasize immunology in our studies of mechanisms for disease pathogenesis and protection.»

Chronic inflammation can be argued to be the underlying mechanism for all disease.

I would save the «outstanding» (personally) for a thesis that discovered a new cancer drug or a new mechanism for a disease that immediately suggested ways to look for new treatments.

Not exact matches

And a third, different kind of gene therapy from Spark Therapeutics — to treat a rare inherited form of blindness — is likely to be approved by the end of 2017, too, making this year a landmark for treatments that manipulate the body's own biological mechanisms in novel new ways to fight deadly diseases.

In those areas that we have mapped, it typically takes us a few hours to go from a mechanism - inspired idea for treating a disease to knowing the companies that might have relevant clinical and preclinical assets to license, the companies from whom a candidate could be commissioned, trial designs and endpoints, competing and complementary agents, current and future standard of care, market size, comparable pricing, financing strategy, and potential acquirers, all meant to enable a thoughtful first - pass assessment of whether an idea could be worth a much deeper assessment.

MIN - 102 has a unique mechanism of action for X-ALD, a genetic disease characterized by progressive neurologic deterioration with no available pharmacological treatment.

Minoryx harnesses its unique mechanism of action for potential use in X-ALD, a genetic disease characterized by progressive neurologic deterioration with no available pharmacological treatment.

«With the Immunoscape platform, we are seeking to develop a molecular map of inflammatory diseases that will help us identify and characterize disease mechanisms,» Jessica Mega, chief medical officer for Verily, said in Monday's announcement.

The Global Burden of Disease Study 2010 predicted that sugar sweetened drink consumption contributes a relatively small amount to UK population morbidity (28000 disability adjusted life years) compared with low fruit and vegetable consumption (1130000 disability adjusted life years).59 Using revenue from a sugar sweetened drink tax to reduce the prices of fruit and vegetables is a potential mechanism for further improving population health.60

In May 2000, the Archives of Disease in Childhood published research showing that scrotal temperature is increased in boys wearing disposable diapers, and that prolonged use of disposable diapers will blunt or completely abolish the physiological testicular cooling mechanism important for normal spermatogenesis.

It occurs because of the spontaneous release of pyrogens, our body's natural defense mechanism for fighting disease.

Not only does breast milk have the right nutritional balance for your baby, but it also contains growth factors, antibodies, and other mechanisms that protect your baby against infections and other diseases throughout his lifetime.

For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.

«The discovery of HDMP in humans means that for the first time we are seeing an important mechanism in the process which causes the disease.

For example, the curation effort could uncover information that suggests specific biomarkers or readouts researchers could test in the lab to gain insight into disease mechanisms — or, in the best case, lead to a cure for NGLY1 deficienFor example, the curation effort could uncover information that suggests specific biomarkers or readouts researchers could test in the lab to gain insight into disease mechanisms — or, in the best case, lead to a cure for NGLY1 deficienfor NGLY1 deficiency.

«Given this mechanism, ataluren offers the potential for a new therapeutic approach for multiple nonsense mutation genetic disorders by targeting the underlying cause of the disease.»

Right now the research team is teasing out further details of the disease mechanism since this will steer researchers on a path towards much - needed treatment for motor neuron diseases.

Future work exploring this possibility will likely produce new insights into mechanisms essential for human wellbeing and deregulated in disease.

But even when the genetic mechanism is more complex, he adds, the new approach might yield insights into underlying disease processes that could pave the way for more finely targeted treatments.

«It could be one of the mechanisms for genetic inheritance of disease — a route we haven't thought of before,» says Spector.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

The existence of two mechanisms would make sense for what we know about biology: Salt is necessary for life, but too much salt can kill you, and not just in the sense that excess salt in the diet may be behind some cases of heart disease.

Furthermore, an inactive lifestyle itself is a risk factor for cardiovascular disease, although the physiologic mechanisms for this effect are unknown.»

«How the microbiome is linked to autoimmune disorders: Discovery of new mechanism in the gut microbiome has implications for inflammatory bowel disease.»

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

Gaining a better understanding of the underlying disease mechanisms could offer the possibility of developing new and better treatments for lupus and other autoimmune conditions in the future.

Finally, while the underlying mechanism is unclear, the team found that having reduced NOX2 - derived reactive oxygen species also raised the risk for these autoimmune diseases.

Tuncay Baubec, professor at the Department of Molecular Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA.

Professor Nutt said increasing our knowledge of the mechanisms that controlled the immune response was vital for understanding how immune and inflammatory diseases arise and, ultimately, developing more effective treatments.

«With all our medications, we're attempting to develop an understanding of the mechanism of the disease and an understanding of which patients will respond, so that we can treat those patients who will respond and not those who won't,» comments Richard Scheller, executive vice president of research for Genentech.

«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.

Disgust is the mechanism for doing this — causing us to shun people who violate the social conventions linked to disgust, or those we think, rightly or wrongly, are carriers of disease.

The next objective of the researchers is to decode the action mechanism of TREX2 in the development and maintenance of psoriasis, so as to design new therapeutic strategies for the treatment of this disease.

A protein pathology identified by Emory investigators could have major implications for understanding the disease mechanism.

«We were very surprised to find alterations in proteins that are responsible for RNA splicing in Alzheimer's, which could have major implications for the disease mechanism,» says Allan Levey, MD, PhD, chair of neurology at Emory University School of Medicine and director of the Emory ADRC.

This basic fact makes it difficult for researchers to discern the underlying mechanism of the disease: «It's very difficult to figure out what's wrong, because the bone marrow is nearly empty of these cells,» said Bessler, the director of CHOP's Pediatric and Adult Comprehensive Bone Marrow Failure Center.

Vitamin D also reduces inflammation, an underlying mechanism for obesity related development of coronary artery disease, says Raed.

Researchers have found that revulsion activates the brain's harm - avoidance center, invoking notions of cleanliness and moral purity as a primal mechanism for avoiding disease.

The authors note that while large, international, multi-lateral funds exist for global health delivery, there is no significant pooled funding mechanism for research and development to complement existing but limited R&D funding for a wide range of diseases.

«The practice of the Wim Hof Method may lead to tonic changes in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from diseases of the immune system to more intriguingly psychiatric conditions such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.

► On the News site on Sunday, Sarah C. P. Williams wrote about a recent study that suggests a possible mechanism for how stress can lead to cardiovascular disease.

«Aging is an underlying timing mechanism for all chronic diseases,» says David Harrison, a collaborator with Sharp and other rapamycin researchers at the Jackson Laboratory in Maine.

Understanding the mechanisms of inflammation in rheumatoid arthritis is important for the design of new therapies for this disease.

However, many industry insiders say these changes are opening up unique opportunities for researchers who focus on translating basic science into real - world cures and are eager to explore the molecular mechanisms of disease, test hypotheses, and do work that benefits patients.

«The more steps in the mechanism we can understand, the more therapeutic targets we'll find for Alzheimer's disease.»

This potential common mechanism could help explain why physical exercise and diet, classic ways of reducing risk of heart disease, for example, are also thought to improve mood and help depression.

By pairing a receptor that targets neurons with a molecule that degrades the main component of Alzheimer's plaques, the biologists were able to substantially dissolve these plaques in mice brains and human brain tissue, offering a potential mechanism for treating the debilitating disease, as well as other conditions that involve either the brain or the eyes.