Sentences with phrase «mechanism of action at»

«Cimetidine is one of the most interesting examples of repurposed drugs in oncology — a drug with an extensive history of pre-clinical and clinical evidence of efficacy in a range of different cancers and with multiple mechanisms of action at work,» says Pantziarka.

The symposium will focus on the roles of the major enzymes participating in metabolism of xenobiotics including carcinogens and drugs — the membrane monooxygenase systems containing cytochromes P450 — and highlight the key advances in their mechanisms of action at the molecular level.

Not exact matches

This week in Beijing, Mr. Wang Qishan, vice premier and leader of the Chinese delegation at the fifth Sino - US Strategic Economic Dialogue (SED), a mechanism launched in 2006 to discuss long - term strategic issues between the two countries, called on the US to take swift action to protect Chinese investments in the US.

I don't believe in gods at all, I am certain that organized religions are a mechanism of control, and I believe that at the beggining, middle, and end of the day we are all responsible for our own lives and actions (which is why it is so important that we humans that actually live and die in this world figure out how to work together).

Governor Ambode, who spoke at the May Day Rally, held at the Agege Stadium, Lagos, while attributing the industrial harmony and peace in the State to the maturity and responsibility of the labour unions, applauded them for adopting alternative dispute resolution mechanisms rather than resort to industrial actions.

Looking at his speech closely, Mr Miliband argues for «collective action» through the mechanisms of the State.

«Suppose a scientist at a biotech wants to study a drug's mechanism of action,» Parikh explains.

«One Profession, Multiple Careers» is only a year - and - a-half old, and the bottom - up approach used to develop instruments like this usually takes a long time to develop, since its main mechanism of action is persuasion via discussions at conferences and workshops.

A study published by scientists at University of Massachusetts Medical School and the University of Alabama at Birmingham provides insight into the mechanism of action of the drug ataluren, which is showing promise in treating Duchenne muscular dystrophy and cystic fibrosis.

At Cornell, Bowen wrote a research proposal to examine the mechanism of action between opiates and their receptors, a mechanism that was largely unknown at the timAt Cornell, Bowen wrote a research proposal to examine the mechanism of action between opiates and their receptors, a mechanism that was largely unknown at the timat the time.

The team is also testing the resolution of the microfluidic system with other reagents and materials, bringing researchers one step closer to viewing live biological mechanisms in action at the highest levels of resolution possible.

Determining the detailed molecular mechanism that mediates the therapeutic actions of cannabidiol may suggest development strategies for new drugs aimed at GPR55, according to the researchers.

Using a special profiling technique, scientists at Princeton have determined the mechanism of action of a potent antibiotic, known as tropodithietic acid (TDA), leading them to uncover its hidden ability as a potential anticancer agent.

Jordi Mestres, coordinator of the IMIM and UPF research group on Systems Pharmacology at the Biomedical Informatics Program (GRIB) states «With this study we have contributed to complementing the detection of these quite unstable fragments, with information on the mechanism of action of the drug, based on three aspects: similarity to other medicines, prediction of their pharmacological profile, and interference with specific biological pathways.

There are (at least) two sets of programs under the MC actions that you are likely to be interested in: individual fellowships and the «return and reintegration mechanisms.»

Prof. Christoph Dehio's research group at the Biozentrum, University of Basel, has uncovered a new mechanism of action of toxins from the group of FIC proteins.

At Merck Frosst Canada, I have been an integral part of the discovery of a new molecule, the testing of its mechanism of action, the validation of its safety and efficacy in Phase IIb and III clinical trials, the market approval of the resulting product, and the subsequent management of patients and their disease.

A potential new antidepressant and anti-anxiety treatment with a unique mechanism of action has been developed by scientists at the University of Bath.

She started her scientific career as an undergraduate and then PhD fellow at the Pasteur Institute, Paris, France, uncovering the molecular basis of IFN - induced OAS proteins in mediating resistance to West Nile virus infection and characterizing the molecular mechanism of action of DC - SIGN surface lectin polymorphisms that associate with severe Dengue hemorrhagic fever.

«While further studies are planned to dissect more precisely their mechanism of action in the context of brain aging, our preliminary data point at a role in modulating neuroinflammation, but we have not ruled out additional mechanisms.»

Previously, Dr. Joyal served as Director of Discovery Research at Phylogix Pharmaceuticals, where he led a team evaluating the biology and mechanism of action of protein therapeutics for oncology supportive care.

Our product candidates are also intended to combine with other mechanisms of action across the oncology landscape, such as checkpoint inhibitors or engineered T cells, to increase the benefit to patients and potentially place Immune Design at a central place in the treatment paradigm.

Taking inspiration from the defense mechanism of the bombardier beetle, researchers at ETH Zurich have developed a film that, when damaged, instantly releases a hot foam to discourage malicious actions.

«We should look also at older drugs that may have been discarded, and perhaps work more to understand the mechanism of action of acetaminophen to develop a new, more effective and less toxic drug of the same class, or develop new classes of painkillers,» Moore suggested.

Just like the same area of the brain lights up when you eat tasty food, have sex, or watch an action - packed film; a similar mechanism is at play as you increase discipline.

Despite numerous positive studies, the mechanism of action is not clear at this time.

Whilst we can see that the diet does appear to offer significant anticonvulsant for those with refractory epilepsy, more work is needed to truly understand the exact mechanism of action that is at play.

«These results suggest that 1) chronic ERT [Estrogen Replacement Therapy] likely acts centrally to decrease Tre [temperaure], 2) ERT lowers the Tre at which heat - loss effector mechanisms are initiated, primarily by actions on active cutaneous vasodilation, and 3) addition of exogenous progestins in HRT effectively blocks these effects.»

However, based on the relationship of excess dietary methionine to vital organ toxicity, as well as its likely mechanism of action through increases in free radical generation, the possibility exists that the protective effects of plant - based diets can be due, at least in part, to their lower methionine content.

Nutrient Interaction / Contraindication Based on the mechanism of action of this nutrient and its proven safety in research studies, 10, 13 NO interactions or contraindications are known at this time.

Dr. Lee takes a close look at how to recognize the best form of CoQ10, based on dosage, absorbability, and mechanism of action.

Researchers have already identified at least one mechanism of action involved with this immune system support.

Looking at more dynamic movements, tools such as the RMT Club, ViPR, and the Mace are excellent mechanisms that allow freedom of movement and work in virtually every action that the shoulder performs.

Researchers are not clear about the mechanism of action here, but continue to look at relationships between increased intake of cow's milk and decreased levels of uric acid in the blood.

The idea that the protective effect is not due to any of the [individual plant food] components, but to a [synergistic] «combined effect» is gaining acceptance... However, based on the relationship of excess dietary methionine with toxicity to major vital organs, and its likely mechanism of action through increases in [free radical] generation, the possibility exists that the protective effects of [plant - based] diets can be due, at least in part, to their lower methionine content.»

Like raisins and grapes, which are also toxic, the exact toxin and mechanism of action to cause signs of poisoning in some dogs are not known at this time.

Many flea - control products are available, and veterinary technicians should be knowledgeable about the products offered at their practice, including the mechanism of action and proper administration.

In this post we shall take a closer look at this particular product and learn more of its mechanism of action and why many vets and pet owners alike actually recommend this product over other brands.

West's sculptures are a response to the mechanism of action and reaction that lies at the heart of the relationship between spectator and object.

Bart Verheggen says: August 14, 2011 at 3:03 am So how do past climate changes (from snowball earth to the hothouse Cretaceous) fit in your paradigm that «that the temperature of the Earth is kept within a fairly narrow range through the action of a variety of natural homeostatic mechanisms.»?

This latest report was made at the conclusion of these negotiations during which almost no progress was made in defining equity under UNFCCC by the Ad Hoc Working Group on Durban Platform For Enhanced Action (ADP), a mechanism under the UNFCCC that seeks to achieve a adequate global climate agreement, despite a growing consensus among most observers of the UNFCCC negotiations that nations need to align their emissions reductions commitments to levels required of them by equity and justice if the world is going to prevent extremely dangerous climate change.

At the Ontario Bar Association's Institute 2015 conference — now in full swing, with 1,700 participants converging in downtown Toronto — Osler's Jennifer Fairfax delivered a paper that describes a litany of failed attempts to certify an environmental class, and ultimately suggests class actions may not be the preferable mechanism for dealing with environmental claims.

The IAP is the mechanism through which people who suffered serious physical, sexual, or psychological abuse at residential schools can apply for additional compensation on top of the base class action settlement.

Whilst a stagiaire at the Court of Justice of European Union, Jack worked on cases including: Kadi II (the effect of European procedural rights), Pringle (the validity of the European Stability Mechanism), Abdulrahim (continuing interest to bring an action for annulment), and Inuit I (the definition of regulatory acts in Article 263 TFEU for the purposes of standing).

Nearly 150 responses were sent to the Commission expressing a wide range of views, and the European Parliament has agreed that the Commission should take forward work in this area with a view to improving the use of private actions, noting that «the existing redress mechanisms for breaches of competition rules at European level do not guarantee the full effectiveness of Article 81 of the Treaty, in particular with regard to those suffering damage» (Parliament resolution of 25 April 2007).