Sentences with phrase «mechanism of action involved»

Researchers have already identified at least one mechanism of action involved with this immune system support.

«Our study has found that Hsp90 inhibition can specifically stop resistance to hormone treatments in prostate cancer, through a completely new mechanism of action involving the processing of messenger RNA.

«The fact that the mechanism of action involves the p38 MAPK enzyme is fortuitous because drugs to combat that pathway are being tested for other diseases.

Not exact matches

«These findings reveal a unique fulvestrant signaling process involving the increased regulation of hsa - miR - 765 that suppresses the HMGA1 protein as part of the mechanism underlying the tumor suppressor action in prostate cancer.

The channel - like property could have evolved, says Edwards, to meet the important need of moving large amounts of glutamate quickly, for while the other neurotransmitters are involved in modulating behaviors, such as mood, and therefore don't need to act with millisecond speed, glutamate functions by rapid - fire communication between closely placed nerve cells, and could require the fast action of the channel mechanism.

The mechanism of action here is thought to involve resistance to oxidative damage and increased quality control of damaged proteins.

The mechanism of p21waf1 / cip1 induction caused by these factors often involves the action of corresponding transcription factors on the p21waf1 / cip1 promoter (17).

She is also involved in identifying the mechanism of action of anti-tubercular compounds.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Their recent study, published in PNAS (3), characterizes the mechanism of action of a smooth muscle myosin inhibitor, CK - 2018571, that induces smooth muscle relaxation and can be used to treat diseases involving smooth muscle hypercontractility, such as asthma and chronic obstructive pulmonary disease.

These antioxidants, as well as carotenoids and dietary fiber, are also likely to be involved in kiwi's ability to strengthen the immune system, although the exact mechanism of action is still not completely understood.

Most of the proposed mechanisms of actions in these studies involve changes in cell signaling and decreased production of pro-inflammatory cytokines.

However, the mechanism of action by which the consumption of dietary protein elicits these responses remains unclear but has been postulated to be involved with dopamine production.

Possible mechanisms of action for tea on DM may involve 1 or more physiologic pathways.

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Specifically, Ms. functioning should Lowell's current dissertation project aims have the capacity to to examine early childhood adversity and other mechanisms of action in the understand their own prediction of child maltreatment potential emotions, regulate those in substance - involved mothers.

This study (NIMH #R01MH108793) will evaluate the effectiveness of a comprehensive treatment for emerging adults who are justice - involved and have serious mental illness, as well as examining the mechanisms of action for such treatments.

This study (NIDA #R01 DA041425 - 01) will evaluate the effectiveness of comprehensive treatment for justice - involved emerging adults with alcohol and other drug (AOD) abuse, as well as examining the mechanism of action for such treatments.

In addition to a national plan of action, a coordinating body or mechanism to coordinate the many levels and sectors of Australian governments who would be involved in the achievement of Indigenous health equality is necessary.