Sentences with phrase «mechanism of action of»

Experienced in investigation of Mechanism of Action of novel immunobiologics in investigator - initiated and clinical studies using disease - related biomarker selection and analyses.

If the action of Advantage II is to block the transmission of nerve impulses in adult fleas leading to their paralysis, the mechanism of action of Frontline Plus is the opposite.

The mechanism of action of Simplicef (Cefpodoxime) is similar to other cephalosphorins except that its antibacterial spectrum occurs on a much broader scale.

The clinical indications of Temaril P tablets for dogs are directly related to the mechanism of action of its two principal components.

The complete mechanism of action of this product is not completely understood, but appears to work on several different areas in cartilage protection and synthesis.

The mechanism of action of immunotherapy is complex and not completely understood; however, the reported success rate is 50 % to 80 %.1

The mechanism of action of K9 Advantix II is inherent in the action of its 3 principal ingredients imidacloprid, permethrin, and pyriproxifen.

Unlike other pain relievers, acetaminophen does not block the production of prostaglandins to reduce pain and fever — the exact mechanism of action of acetaminophen is not well known.

This case report describes the mechanism of action of sildenafil, along with recognition and management of a typical case of sildenafil exposure.

David Grimes wrote a 672 page book about this subject just months ago: http://www.vitamin-d-deficiency.co.uk/ Magn is also required in each of the steps concerned with replication, transcription, and translation of genetic information, and thus it is also needed for the genetic mechanism of action of Vitamin D. To make things even more interesting, Ca / Magn - ratio seems to be one of the stronger single predictor of fatal heart attacks I can think of.

The basic mechanism of action of forskolin is the activation of an enzyme, adenylate cyclase, which increases energy levels in cells.1 These enzymes are perhaps the most important cell - regulating compounds.

The mechanism of action of chrysin was compared to diazepam, and it was shown that unlike diazepam, chrysin can reduce anxiety without inducing the common side - effects associated with benzodiazepine drugs.

In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed.

Nutrient Interaction / Contraindication Based on the mechanism of action of this nutrient and its proven safety in research studies, 10, 13 NO interactions or contraindications are known at this time.

Identification and mechanism of action of phospholipids capable of modulating rat testicular microsomal 3 beta - hydroxysteroid dehydrogenase - isomerase activity in vitro GM Cooke Biol Reprod, Sep 1989; 41: 438 - 445.

The mechanism of action of Omega 6 fatty acids on the body systems is still not completely understood.

It was discovered when researchers were looking for the mechanism of action of a novel immune suppressing drug called rapamycin.

However, the mechanism of action of lemon balm is yet to be fully understood.

Does a high fiber intake ingested within 10 - 15 minutes of taking prescription pills (i.e. blood pressure meds: diuretics, ACE inhibitors, ARBs; or anti-depressants: SSRIs, SNRIs) have an affect on the absorption or mechanism of action of the prescription meds.

The mechanism of action of Eurycoma Longifolia Jack is the complete opposite.

In this study we investigated the cellular mechanism of action of alpha - lipoic acid in 3T3 - L1 adipocytes.

Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis.

«We should look also at older drugs that may have been discarded, and perhaps work more to understand the mechanism of action of acetaminophen to develop a new, more effective and less toxic drug of the same class, or develop new classes of painkillers,» Moore suggested.

This compound is known as Transfer Factor and whilst there is a large scientific literature on this subject, the nature and mechanism of action of Transfer Factors are largely unknown.

In order to validate that the observed cell death was specific to the action of amiodarone HCL, and possibly dissect the mechanism of action of this compound, we performed a gene expression analysis of NSCs and postmitotic neurons receiving amiodarone HCL.

Haploinsufficiency in DYRK1A is associated with a recognizable developmental syndrome, though the mechanism of action of pathogenic missense mutations is currently unclear.

It is precisely in St. Louis that in 1954 with her colleague Stanley Cohen she uncovered the nature and mechanism of action of a protein molecule which became known, on account of its biological properties, as the «Nerve Growth Factor» (NGF).

Their recent study, published in PNAS (3), characterizes the mechanism of action of a smooth muscle myosin inhibitor, CK - 2018571, that induces smooth muscle relaxation and can be used to treat diseases involving smooth muscle hypercontractility, such as asthma and chronic obstructive pulmonary disease.

This work was carried out in collaboration with the KEMRI - Wellcome Trust Research Programme, and relates to Alexis's longstanding interest in the mechanism of action of antimalarial drugs such as lumefantrine, piperaquine and amodiaquine.

She is also involved in identifying the mechanism of action of anti-tubercular compounds.

The system can be used by researchers as a model to elucidate how viral infections contribute to exacerbations, gain insight into mechanism of action of drugs, and could potentially help identify new therapeutic targets.

We hypothesize that the mechanism of action of J147 is related to its ability to increase the levels of BDNF and NGF, and studies are being conducted to identify its molecular target.

However, we still do not know the mechanism of action of CD36 + metastatic - initiating cells, and how extracellular free fatty acids and / or lipids contribute to metastatic progression in oral SCC.

However, significant follow - up work is needed to understand the mechanism of action of these variants.

Previously, Dr. Joyal served as Director of Discovery Research at Phylogix Pharmaceuticals, where he led a team evaluating the biology and mechanism of action of protein therapeutics for oncology supportive care.

Twenty - two years passed before the structures of these proteins were established; the significance of the work is that it provided the basis for an understanding of the mechanism of the action of enzymes and other proteins, an active and fruitful subject of modern investigation.

He completed his postdoctoral training from Columbia University where he later joined as a research scientist to continue his work on identifying master regulators (MR) of various pathologies, developing methods for biomarker discovery and understanding mechanism of action of compounds.

Further studies into the mechanism of action of NBDNJ have led to important findings regarding how the virus moves in the cell.

«The mechanism of action of pidilizumab should allow for single agent activity, although we believe the combination of rituximab and pidilizumab should yield greater results than with CT - 011 alone,» said Westin.

She started her scientific career as an undergraduate and then PhD fellow at the Pasteur Institute, Paris, France, uncovering the molecular basis of IFN - induced OAS proteins in mediating resistance to West Nile virus infection and characterizing the molecular mechanism of action of DC - SIGN surface lectin polymorphisms that associate with severe Dengue hemorrhagic fever.

This will include testing the mechanism of action of different adjuvant and antigen formulations by measuring B - and T - cell responses and by using various functional assays (ELISA, FACS, cytokine profiles), transcriptomics and / or proteomics.

«The data further confirms the mechanism of action of Cirara.»

The researchers say they now understand the mechanism of action of amphotericin, an antifungal drug that has been in use for more than 50 years — even though it is nearly as toxic to human cells as it is to the microbes it attacks.

That may change when scientists learn more about the mechanism of action of free radicals and the effects of special diets on ageing.

Scientists have debated the mechanism of action of captagon, and Janda's vaccine approach has been useful in dissecting how the components of the drug exert their psychoactive effects.

Welinder says the mechanism of action of sex hormone - binding globulin during hibernation still remains elusive.

Prof. Christoph Dehio's research group at the Biozentrum, University of Basel, has uncovered a new mechanism of action of toxins from the group of FIC proteins.

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

His research focuses on the development of high - precision, single - molecule methods to study the mechanism of action of macromolecular machines, such as dynein, telomerase, and Cas9.

Newly - discovered mechanism of action of the bacterial superantigen toxins: Superantigens bind to both B7 - 2 and CD28, the major costimulatory receptors expressed on human immune cells.