Sentences with phrase «mechanism of action studies»
Collaborated with biology colleagues to develop and prepare reagents for binding assays and mechanism of action studies, including biotinylated and radiolabelled derivatives.
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Trained as an enzymologist, Dr. Zhang has expertise in inhibition kinetics and mechanism of action studies for HTS hits and lead compounds.
Not exact matches
We are currently performing studies to test the duration of protection induced by the vaccination, as well as to further elucidate the mechanism or mechanisms of action.
To understand this mechanism better, Chen used mice to study the action of morphine, a painkiller that can cause itching.
«Suppose a scientist at a biotech wants to study a drug's mechanism of action,» Parikh explains.
Commenting on the study for ESMO, Dr Olivier Michielin, head of Personalised Analytical Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, said: «Omaveloxolone's novel mechanism of action is to block MDSCs, cells known to suppress the immune response.
A study published by scientists at University of Massachusetts Medical School and the University of Alabama at Birmingham provides insight into the mechanism of action of the drug ataluren, which is showing promise in treating Duchenne muscular dystrophy and cystic fibrosis.
«Understanding the mechanism of action of this peptide will help in translational studies to further assess the potential for this peptide to be used in medicine,» Beales says.
UIC's Alexander Mankin and Yury Polikanov are corresponding authors on the study and led the research on the antibiotic's mechanism of action.
«These findings are the result of years of NHLBI - funded studies of the molecular mechanisms of action of GPIHBP1 and are an excellent example of how basic science can lead to scientific advances with direct clinical implications.»
«The study demonstrates a new mechanism of action for INF - β therapies,» says Dr. Rostami.
Jordi Mestres, coordinator of the IMIM and UPF research group on Systems Pharmacology at the Biomedical Informatics Program (GRIB) states «With this study we have contributed to complementing the detection of these quite unstable fragments, with information on the mechanism of action of the drug, based on three aspects: similarity to other medicines, prediction of their pharmacological profile, and interference with specific biological pathways.
Despite small clinical studies that have reported efficacy of the approach, the mechanism of action is poorly understood.
His research focuses on the development of high - precision, single - molecule methods to study the mechanism of action of macromolecular machines, such as dynein, telomerase, and Cas9.
«It's important to understand the mechanisms of action of chemotherapy on spermatogenesis to help clinicians make informed decisions on adjusting treatment, reducing side effects, and better advising patients on family planning,» says INRS's Dr. Géraldine Delbès, reproductive toxicology specialist and the author in charge of this study.
The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.
The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»
«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»
Our studies suggest that direct activation of membrane chloride conductances is a general mechanism of action for biogenic amines in the modulation of C. elegans behavior.
According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.
This is the result of one of the largest multicentre, international studies so far into difficult - to - treat rheumatoid arthritis, focussing on this new mechanism of action, an interleukin - 6 cytokine blockade.
«Our study has found that Hsp90 inhibition can specifically stop resistance to hormone treatments in prostate cancer, through a completely new mechanism of action involving the processing of messenger RNA.
Further studies into the mechanism of action of NBDNJ have led to important findings regarding how the virus moves in the cell.
«While further studies are planned to dissect more precisely their mechanism of action in the context of brain aging, our preliminary data point at a role in modulating neuroinflammation, but we have not ruled out additional mechanisms.»
Dr. Tarazi studies the behavioral, genetic, molecular, and cellular mechanisms that mediate the actions of dissimilar psychotropic drugs by using animal models that mimic the core symptoms of different neuropsychiatric diseases.
The finding «solves a big puzzle about the drug's mechanism of action,» says a co-author of the study and the drug's creator, Frank McCormick, PhD, director of the UCSF Comprehensive Cancer Center, and co-founder of Onyx Pharmaceutical Inc., which develops the drug.
The study was led by Dale Boger, co-chair of TSRI's department of chemistry, who said the discovery made the new version of vancomycin the first antibiotic to have three independent «mechanisms of action'to kill bacteria.
We hypothesize that the mechanism of action of J147 is related to its ability to increase the levels of BDNF and NGF, and studies are being conducted to identify its molecular target.
He spent his basic research career studying the mechanisms of steroid hormone action on the brain, behavior, and mental health, and the influences of the environment and stressors on those actions in laboratory rodents.
This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.
In the current study, which was conducted in mice, scientists have analyzed one particular single nucleotide variant in a region associated with increased risk for developing colorectal and prostate cancers, but whose mechanism of action has been unclear.
When a clinical trial of a vaccine begins, scientists hope that the study will add useful information about the efficacy of the vaccine and its mechanism of action.
Their recent study, published in PNAS (3), characterizes the mechanism of action of a smooth muscle myosin inhibitor, CK - 2018571, that induces smooth muscle relaxation and can be used to treat diseases involving smooth muscle hypercontractility, such as asthma and chronic obstructive pulmonary disease.
Other studies in the laboratory focus on the molecular mechanisms underlying HIV latency, including a role for host proteins and miRNAs that reinforce the latent state as well as the action of host proteins such as NF - kB that antagonize latency.
Another study also found that curcumin had a significant effect on «several biomarkers that may be associated with its antidepressant mechanisms of action» (17).
Despite numerous positive studies, the mechanism of action is not clear at this time.
Curcumin's mechanisms of action in the brain have been studied extensively.
The exact compounds and mechanisms of action that gives echinacea its powerful medicinal value are still not entirely understood, but the herb has been found to contain fat - soluble alkamides, caffeic acid, and polysaccharides, whereas its volatile oil contains humulene, which in vitro studies have suggested to possess anti-inflammatory effects.
In this study we investigated the cellular mechanism of action of alpha - lipoic acid in 3T3 - L1 adipocytes.
However, the effects of gluten - free diets on obesity and its mechanisms of action have not been studied.
The specific mechanism of action has not been well documented though, as most studies have not drawn a clear line between blood levels of vitamin D and disease prevention.
Studies to date have demonstrated that phytochemicals in common fruit and vegetables can have complementary and overlapping mechanisms of action, including modulation of detoxification enzymes, scavenging of oxidative agents, stimulation of the immune system, regulation of gene expression in cell proliferation and apoptosis, hormone metabolism, and antibacterial and antiviral effects (15, 16).
A 2014 systematic review of clinical studies and examination of underlying antidepressant mechanisms of action of saffron found that:
Further studies are necessary to properly understand ginger's mechanism of action; however, some evidence suggests that it can improve the symptoms of Irritable Bowel Syndrome (IBS) by reducing pain and regulating gut motility.
Another mechanism of action was suggested by a Chinese study published in the Journal of Agricultural and Food Chemistry in 2005.
The results of this study lead to the conclusion that obese subjects who eat in response to stress may benefit from taking a diet supplement containing extracts of Magnolia and Phellodendron, where the mechanism of action is through the reduction of cortisol levels and possibly perceived level of stress, helping the subjects maintain body weight.
Nutrient Interaction / Contraindication Based on the mechanism of action of this nutrient and its proven safety in research studies, 10, 13 NO interactions or contraindications are known at this time.
Mechanisms of Action In the brain L - theanine increases dopamine and serotonin production, [4] although one study showed a decrease in serotonin in rats administered theanine.
Most of the proposed mechanisms of actions in these studies involve changes in cell signaling and decreased production of pro-inflammatory cytokines.
For our military, the greatest impact of this study is the potential preservation of life and operational utility of canine force - multipliers following trauma while simultaneously improving our understanding of the mechanism of hemostatic action of TXA.