Sentences with phrase «mechanism of activation»

In collaboration with L. David Sibley at the University of Washington in St. Louis, our group solved the first rhoptry kinase structures (ROP2A and ROP8), enabling us to propose a hypothesis for their mechanism of activation [Qiu et al, EMBO, 2008].

«RIG - I essentially alerts the immune system to the presence of viruses and sets off an immune response, but many aspects of its mechanism of activation were unclear,» explains Gack.

Thompson is the corresponding author for the journal article, «Molecular Characterization of Latent GDF8 Reveals Mechanisms of Activation,» and its first author, Ryan Walker, is a postdoctoral fellow at Harvard University and a former UC doctoral student who once worked in Thompson's laboratory.

Not exact matches

Capsaicin induces the sustained activation of EGFR downstream signals through the induction of EGFR transactivation mediated through Src and MMP - dependent mechanisms.

Above all, mechanism / processes for the establishment and activation of inter community vigilante groups would be established by the civil power in Ebonyi State to help to de-escalate tension and address emerging security challenges across the communities and its environs.

Soluble CD14 levels were inversely correlated with measures of bone mineral content and density, suggesting macrophage activation as a possible mechanism for such bone loss.

In the current study, Lee set out to understand the mechanism underlying the activation of brown fat.

Model of a glycoprotein hormone receptor (white backbone ribbon) with bound hormone and the activating antibody visualizes a potential arrangement and the principle mechanism of glycoprotein hormone receptor activation.

The underlying mechanism involves the activation of the immune system, resulting in local inflammation and proliferation of skin cells.

Reasoning that direct insertion of a metal into the bond would face too high an energy barrier, the authors implemented a dual activation strategy, targeting a mechanism in which gold coordination enhances the reactivity of the C - C triple bond while trifluoroacetate coordination to B stimulates transfer of the adjacent O group.

The scientists describe in the online edition of the journal Nature Structural and Molecular Biology the molecular details of this activation mechanism and the enzymes responsible for it.

But with the design of each well's membrane and activation mechanism, Langer says, «I don't think there are big safety concerns.»

Their work elucidates a dynamic, two - step mechanism in females whereby B cells lacking the markers of X chromosome inactivation regain these modifications during B cell activation, in a process involving the transcription factor YY1.

Using the nanodiscs, the team elucidated the activation mechanism of receptor kinase AgrC and discovered a key regulatory hotspot in the kinase that could greatly affect its activity.

«Because of the important role of UPR in regulating cell life / death decisions, it is critical that mechanisms are in place to prevent unnecessary UPR activation in response to innocuous or low - level stimuli,» said Wilkinson.

«Future investigation of the exact mechanisms responsible for activation of this interesting circuit may provide insights into autism spectrum disorder and other social behavioral disorders.»

The structure of this transcription factor — DNA complex provides insights into possible mechanisms of transcription activation.

The research uncovers some of the mechanisms that drive the rapid activation of neutrophils, says immunologist Andrew Gelman of Washington University School of Medicine in St. Louis.

«Our results have revealed and characterized two classes of GGAA - microsatellites that suggest unique interactions and distinct regulatory mechanisms for distance - dependent activation and repressions.

In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itself.

These trigger the activation of a number of defense mechanisms.

In a study of preclinical models of colorectal cancer, the researchers identified an underlying mechanism for the activation of p53 by FL118.

In the example quoted here, a mechanism composed of seven steps was proposed: It should have seven sets of activation parameters instead of the single activation energy calculated in the Report.

«Surprisingly, we found that calcium avoidance occurred through two mechanisms: activation of a unique class of GRNs, distinct from those that sense bitter compounds and which cause a stop - feeding signal when activated.

The immune activation from the CAR cells was also met with resistance mechanisms, including an upregulation of immunosuppressive pathways which may work against the patient and for the tumor, the researchers found.

Our studies suggest that direct activation of membrane chloride conductances is a general mechanism of action for biogenic amines in the modulation of C. elegans behavior.

But as Hermeking explains, «Activation of IL - 6R upon binding of IL - 6 essentially disables this inhibitory mechanism.

There he studied the fundamental cellular and biochemical mechanisms required for immune cell activation and clearance of infections.

«The mechanism that we have now identified regulates body fat mass independently of leptin, and it possible that leptin combined with activation of the internal body scales can become an effective treatment for obesity,» says Professor Claes Ohlsson at Sahlgrenska Academy, Gothenburg University.

«Although the underlying mechanism leading to this increase in AMD in persons with AIDS is not yet known, it may relate to the state of chronic immune activation and systemic inflammation seen in these patients,» said Dr. Jabs.

Our study reveals a new activation mechanism for protein kinases, which should be considered in the design of drugs that target PKG I,» said Kim.

Kim and colleagues are interested in studying the activation mechanism of protein kinase G I (PKG I) because a mutation of PKG I has been shown to cause thoracic aortic disease, as Kim and his collaborators showed in a previous publication in the American Journal of Human Genetics.

This decreased reward response to alcohol arose via two mechanisms: an initial activation of stress hormone receptors and a subsequent increase in inhibitory signaling in the brain.

«This is not, in my mind, an approach to take during chronic infection, because once infection has been established, the mechanisms of immune activation become much more complicated,» observes Martin Markowitz, staff investigator at the Aaron Diamond AIDS Research Center in New York City.

A self - propagating activation mechanism of downstream inflammasome signaling starts with one molecule of NAIP4 directly binding its microbial ligand.

The mechanism of presynaptic facilitation, therefore, may include activation of one or more serotonergic neurons, which enhance the release of a neurotransmitter by increasing the intracellular concentration of cyclic AMP in the terminals of the sensory neurons.

Remarkably, the scientists found that the two endolysins share this common activation mechanism, despite being taken from different species of Clostridium.

Designed to block the newly identified mechanism of PARP1 activation, these new inhibitors will specifically target PARP1, in contrast to the PARP1 inhibitors currently being tested in clinical trials.

Cells use different molecular mechanisms to orchestrate the activation and deactivation of genes as needed.

In addition to reevaluating how histones control gene activation, the study also reports a new mechanism of PARP1 regulation.

The mechanisms by which TZDs exert these effects on glucose and lipid metabolism are not completely defined, though many of their actions appear to be mediated through activation of the nuclear hormone receptor PPAR - γ.

The Max Planck scientists have now elucidated the atomic structure and the operating mechanism of a protein complex (Ski complex) which is involved in the activation of the cytoplasmic Exosome.

Current working model of effector activation and feedback mechanisms in type I interferon signaling.

These studies revealed that ADAR1 null mutant mouse embryos dye at mid-gestation due to widespread apoptosis and overwhelming interferon responses caused by activation of the dsRNA sensing mechanism mediated by MDA5 - MAVS signaling.

disruption of the mechanisms that control the activation levels of different genes, leading to genes being wrongly activated or inactivated

Mechanisms of Lymphocyte Activation and Immune Regulation XI, 139 — 148.

Estrogen receptor protein interaction with phosphatidylinositol 3 - kinase leads to activation of phosphorylated Akt and extracellular signal - regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action.

Furthermore, the reversible nature of microRNA dependent silencing mechanisms may underlie the rapid activation of satellite cells that are poised to enter the myogenic program.

CD43 regulation of T cell activation is not through steric inhibition of T cell — APC interactions but through an intracellular mechanism.

The mechanism of action is based on the activation of macrophages to defend against tumors by direct tumor cytotoxicity and consequently they secrete cytokines which recruit secondary immune cells, presenting antigen to T cells [5 - 7].