Dr. Massagué gave his ambitious new colleague free rein to pursue the molecular
mechanism of cancer metastasis even though no research of this sort had ever been attempted in his lab, and Dr. Kang had limited background in cancer research and no experience in genomics.
And in 2006, Kristiina Vuori, M.D., Ph.D., an authority on the molecular
mechanisms of cancer metastasis, assumed that leadership role.
Not exact matches
This could be key given that the underlying
mechanisms of metastasis and resistance to
cancer drugs are nothing if not complex interactions in a biological system.
Until now, little was known in preclinical models about the
mechanisms that allow breast
cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasi
cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head
of the Growth Control and
Cancer Metastasi
Cancer Metastasis Lab.
The work also reinforces the importance
of finding tumor cell clusters in the blood as a
mechanism of detecting
cancer metastasis earlier.
She is investigating the role
of glycosylated molecules in tumor progression and
metastasis, tissue - and species - specific expression
of lectin receptors that play a role in regulating host innate immune responses and inflammation, and the immunological
mechanisms underlying chronic inflammation and
cancer development.
His laboratory at the German
Cancer Research Center in Heidelberg and at the Medical Faculty Mannheim
of Heidelberg University is studying the
mechanisms of metastasis with the goal to develop more gentle supportive adjuvant therapies for tumor patients without detectable metastases following surgery
of the primary tumor.
To gain an understanding
of the
mechanism that connects low mtDNA levels with a cellular change that leads to
cancer and
metastasis, Guha, Avadhani and their colleagues set up two systems by which they could purposefully reduce the amount
of mtDNA in a cell.
In a set
of papers out today in the journals Nature Genetics and Nature Communications, researchers at the
Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic
mechanisms that promote
metastasis in the mouse model and also implicated the typical Western high - fat diet as a key environmental factor driving
metastasis.
On - going studies are aimed at examining a hypothesis that A-to-I editing
of miR - BART6 RNAs antagonizes the EBV viral strategy
of manipulating the host cell RNAi
mechanism and consequently promoting
metastasis of certain
cancers such as breast
cancer.
Mechanism of irradiation - induced mammary
cancer metastasis: A role for SAP - dependent Mkl1 signaling.
Species - specific homing
mechanisms of human prostate
cancer metastasis in tissue engineered bone.
Klemke, Wang, and their colleagues are involved in research on aspects
of the basic biology behind
metastasis — trying to identify the signal transduction
mechanisms that lead to the spread
of breast
cancer cells.
Research in the Immunology, Microenvironment and
Metastasis program is aimed at 1) merging basic mechanistic understanding
of multidisciplinary pathways
of host - tumor interactions and metastatic dissemination with novel translational opportunities for diseases diagnosis and immunotherapy, as well as 2) investigating
mechanisms regulating immune responses in
cancer and their potential therapeutic manipulation.
FOXA1 activation, inducing enhancer reprogramming that endows a
cancer cell with metastatic properties, is an epigenetic
mechanism, as opposed to a genetic one, that explains at least one
mechanism of metastasis in this form
of pancreatic
cancer, and likely, other
cancer types as well.
Specific translational studies include: Molecular
mechanisms of migration contribute to
metastasis and subsequently thought to be central to the
cancer progression poor clinical outcome for
cancer patients.
Together, our findings uncover a new
mechanism for liver
metastasis formation involving an active contribution
of hepatic vascular fibronectin and talin1 in
cancer cells.
The major two focuses
of his Ph.D. study were to study the cellular and molecular
mechanisms of prostate
cancer metastasis and to study the effects
of pomegranate derived natural products on prostate and breast
cancer progression.
Researchers are now studying the molecular
mechanisms and signaling pathways
of cancer cell development, proliferation, and
metastasis.
All CM members have research interests in basic
cancer mechanisms, including the normal functions
of oncogenes and tumor suppressor genes; regulators
of cell cycle and apoptosis; regulators
of angiogenesis and
metastasis; and stem cells and blood formation.
Faculty research interests and expertise include
mechanisms of metastasis in
cancer; gene therapy (including electroporation) in
cancer; cell and molecular biology
of tooth eruption; pharmacology and toxicology
of aquatic species; environmental and ecological toxicology; cellular ultrastructure; environmental risk assessment; analytical pharmacology and toxicology; diagnostic neurophysiology; pharmacology
of pain and inflammation; exercise physiology; xenobiotic metabolism and disposition; neurochemistry; pulmonary pharmacology; cardiovascular disease; and cetacean morphology.