Sentences with phrase «mechanism of drug»
Topics include localization of brain function; general functions of specific brain areas; anatomy of the neuron; neurotransmission; mechanism of drug action on neurons; genetic, behavioral, and environmental influences on drug addiction; and addiction as a chronic disease.
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Combining the knowledge of autophagy dysfunction and the mechanism of drug action may thus be rational for designing targeted therapy.
These findings provide a rich resource for researchers investigating the molecular mechanism of drug resistance.
Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance.
If it's a mechanism of drug resistance we need to take that into account.»
While there have been extensive studies on artemisinin, the mechanism of the drug is not well understood.
«Imaging of the joint could help evaluate the mechanism of a drug's therapeutic effect, and if a process turns out to be mediated by more than one chemoattractant, understanding the mechanism would allow the rational design of combination therapies to completely shut down critical steps in the process.»
New mutants have already arisen through the mechanism of drug resistance.
The study found several genes that are associated with resistance to antibiotics, including new genes that might point to previously unknown mechanisms of drug resistance.
Some of these studies are aimed at studying the underlying mechanisms of drug abuse whereas others focus on potential pharmacotherapies.
And most of the time, pharmacogenomics is one of a series of tools — albeit a crucial one — that researchers use to investigate how patients respond to drugs, and the mechanisms of drugs and drug interactions.
His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.
Adrian Mulholland, Professor of Chemistry at the University of Bristol, said: «This work shows how molecular simulations can reveal mechanisms of drug resistance, which can be subtle and non-obvious.
In collaboration with the Broad Institute of Harvard and MIT, Sorger and colleagues leveraged an approach developed as part of the National Institutes of Health's Library of Integrated Network - Based Cellular Signatures (LINCS), a large - scale program that aims to amass molecular data from cells following drug exposure to study the mechanisms of drug response.
Scientists Miquel Duran (left) and Patrick Aloy studied the molecular mechanisms of drug side effects.
The research confirms that GAPDH is one of the targets of salicylates related to aspirin thus, may be significant in the therapeutic mechanisms of drugs for neurological diseases.
The project has the potential to provide important new information about mechanisms of drug resistance in melanoma - a key medical problem - as well as to evaluate the potential of splicing inhibitors as a therapeutic approach in two groups of melanoma pts with different response kinetics.
By providing the first global perspective on the mechanisms of drug resistance in P. vivax, including choloroquine resistance, these studies have the potential to significantly improve current treatment and elimination of vivax malaria.
By isolating drug resistant bacteria, Matthew's work focuses on the identification and characterization of drug targets and mechanisms of drug resistance.
«By understanding how the environment in which the parasite lives influences its susceptibility to drugs and the molecular mechanisms of drug resistance, we hope to be able to develop new intervention strategies to combat visceral leishmaniasis in Brazil.»
Dr. Kim is particularly interested in glutamate homeostasis and the interplay between neural and immune mechanisms of drug dependence and relapse.
Data suggest that some fusions may play a role in mechanisms of drug resistance.
Tags for this Online Resume: Research and developmeny, scientist, oncology, molecular biology and biochemistry, cellular pharmacology, mechanisms of drug action
Not exact matches
The drug targets a wider variety of defence mechanisms used by antibiotic - resistant bacteria and can be used in more situations.
Specialty pharmacies — pharmacies that act as a separate distribution and billing mechanism for big drug firms — aren't unheard of in the world of big pharma, but Valeant's relationship with Philidor was strangely close.
He also noted that many drugs aimed at lessening the effects of Alzheimer's disease work by attempting to improve this attention mechanism.
KeyBioscience designed these drugs, which include BP - 089 and KBP - 056, to have the same broad mechanism of action as KBP - 042 but deliver different effects or potency because of changes to their engineering.
Tecentriq belongs to a class of drugs called PD - 1 inhibitors, which help the immune system to fight cancer by blocking a mechanism that tumors use to evade attack.
The company believes the drug is the first anti-depression drug with a novel mechanism of action in 30 years, and preparations for launch are underway now.
Some of these include poorly absorbed drugs, chiral drugs and other complex delivery mechanisms.
There's no mechanism that gives the consumer some assurance that what they think they're getting is what they're getting,» said Amanda Reiman, the manager of marijuana law and policy at the Drug Policy Alliance.
I hope to empower kids to develop coping mechanisms that will steer them clear of other things people abuse for the sake of comfort, like money, food, alcohol, and drugs.
Physical punishment is associated with a range of mental health problems in children, youth and adults, including depression, unhappiness, anxiety, feelings of hopelessness, use of drugs and alcohol, and general psychological maladjustment.26 — 29 These relationships may be mediated by disruptions in parent — child attachment resulting from pain inflicted by a caregiver, 30,31 by increased levels of cortisol32 or by chemical disruption of the brain's mechanism for regulating stress.33 Researchers are also finding that physical punishment is linked to slower cognitive development and adversely affects academic achievement.34 These findings come from large longitudinal studies that control for a wide range of potential confounders.35 Intriguing results are now emerging from neuroimaging studies, which suggest that physical punishment may reduce the volume of the brain's grey matter in areas associated with performance on the Wechsler Adult Intelligence Scale, third edition (WAIS - III).36 In addition, physical punishment can cause alterations in the dopaminergic regions associated with vulnerability to the abuse of drugs and alcohol.37
«Our goal was to discover the brain mechanisms responsible for the rewarding effects of the drug and the motivation to seek it even after long periods of abstinence,» says Cowan.
«Autism's social deficits are reversed by an anti-cancer drug: Using an epigenetic mechanism, romidepsin restored gene expression and alleviated social deficits in animal models of autism.»
What we're hoping, therefore, is that the new mechanisms we've discovered will help in the development of more targeted drugs, where existing immune - modulating drugs can also be of interest.»
«Suppose a scientist at a biotech wants to study a drug's mechanism of action,» Parikh explains.
And there's increasing evidence that this may be one of the mechanisms by which someone with low levels of dopamine D2 receptors is more vulnerable to taking drugs.
A study published by scientists at University of Massachusetts Medical School and the University of Alabama at Birmingham provides insight into the mechanism of action of the drug ataluren, which is showing promise in treating Duchenne muscular dystrophy and cystic fibrosis.
The Cent - 1 molecule kills cancer cells through a mechanism similar to that of the template drug Rigosertib that is currently under commercial development.
If only we had done this experiment 15 years ago, when vancomycin came into widespread use, we might have understood exactly what kind of resistance mechanisms would follow the drug into our clinics and hospitals.»
«This is wonderfully serendipitous — our drug just happens to be able to overcome both of the biological mechanisms that are key to survival of aggressive lymphoma,» Dr. Melnick says, adding that the inhibitor completely eradicated DLBCL in mice in a short time, with no detectable side effects.
«Naturally occurring mechanism of cancer drug - resistance may itself be a treatment target.»
This could be key given that the underlying mechanisms of metastasis and resistance to cancer drugs are nothing if not complex interactions in a biological system.
«This drug was able to re-activate the disabled microglia,» says Sarkar, «thus restoring the body's natural defense mechanisms and restricting the growth of brain tumor initiating cells.»
A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.
«You can really see the underlying mechanisms, and that has a ton of implications — from understanding how life works to drug design,» said Laszlo.
The aim is to test the first drug that functions according to this mechanism in patients as soon as possible in the course of clinical trials.
But nearly all of these drugs have severe cognitive side effects, which led researchers to speculate that some other mechanism must also be involved.
«As a result,» says Klein, «no one ever actually showed that these drugs were dangerous — they were just assumed to be dangerous based on their mechanism of action.