Sentences with phrase «mechanism of resistance»

His research aims to understand mechanisms of resistance to targeted therapies in cancer and identify potential therapies to overcome that resistance.

Although the general mechanism of resistance has been known for some time, exactly how M2 functions was less clear.

Similar approaches could be used to study the molecular basis of response to a given therapy, as well as mechanisms of resistance to treatment.

In the longer - term, the findings provide an important resource for exploring the underlying mechanisms of resistance.

As a result, we are finding similar mechanisms of resistance.

In the new Nature Medicine study, Oxnard and colleagues looked for mechanisms of resistance to AZD9291 by analyzing liquid biopsies from some of the first patients in the clinical trial whose disease progressed despite treatment with the drug.

The drug works by targeting the same bacterial enzyme that an existing TB drug, isoniazid, hits but in a way that prevents the known mechanisms of resistance.

«Many mechanisms of resistance seem to be in play in these various populations simultaneously,» said study co-author Kenneth Haynes, an entomologist at the University of Kentucky.

I am specifically interested in defining mechanisms of resistance, hypersusceptibility, and dependence to antimicrobial agents in clinical CF bacterial isolates.

A paper published in Nature Genetics March 2, titled «An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia,» shows their findings.

The major mechanism of resistance involves the introduction of mutations in genes encoding penicillin - binding proteins.

Using tumor biopsies from BRAF melanoma patients treated with either BRAF inhibitors or with combined BRAF and MEK inhibitors, a recently FDA - approved drug combination to fight the other mechanisms of resistance, the researchers found that tumors resistant to the BRAF inhibitors had increased levels of autophagy compared with baseline tumors.

The lab of Elisa Oricchio at EPFL has now carried out a study to identify mechanisms of resistance to ibrutinib.

The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative splicing, a novel mechanism of resistance that allows a single DNA sequence to code for many variants of a protein.

Further research into the molecular mechanisms of resistance would be required to fully understand these cross-resistances.

Our work further suggests that in order to optimize use of PARPi, strategies will need to be developed to mitigate such mechanisms of resistance.

Multiple mechanisms of resistance to PARPi have been proposed (reviewed in ref.

[3] These cancers are extremely resistant to the treatment options available for other breast cancers, with drug efflux being the primary mechanism of resistance.

Therefore, strategies for understanding mechanisms of resistance and determining how to therapeutically target specific gene fusion partners are also being explored.

«Many mechanisms of resistance to Bt proteins have been proposed and studied in the lab, but this is the first analysis of the molecular genetic basis of severe pest resistance to a Bt crop in the field,» said Bruce Tabashnik, one of the paper's authors and the head of the Department of Entomology in the UA College of Agriculture and Life Sciences.

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

The mechanism of resistance in this variety was found to be antibiosis, and the level of resistance was found to be equal to that of the most resistant sources known to sorghum breeders in the world.

«Indeed, we believe AR - V7 and other, related variants are a mechanism of resistance in this disease and patients who have them may have a poorer prognosis.»

«This fact reinforces just how complex the mechanisms of resistance to chemotherapy can be,» says Luke Whitesell, a senior author of the PNAS paper and senior scientist at Whitehead Institute

«This is a huge leap, but it doesn't really nail the mechanism of resistance,» Sullivan says.

«The surprising part was that the mechanisms of resistance all funneled through one signaling pathway, ultimately, but the way that they start is frequently different,» said Dr. Aplin.

«Here, we show that the BRAF inhibitors induce autophagy as a way to escape cell death, which gives us clues on how to interfere with this mechanism of resistance and improve outcomes for these patients.»

Wilson, M. Z.; Wang, R.; Gitai, Z.; Seyedsayamdost, M. R. «Tropodithietic Acid: Mode of Action and Mechanism of Resistance.»

Dr. Douillard, lead author of the study, says his next steps are to «look for resistance mutations, like T790M, during treatment to better understand mechanisms of resistance and anticipate later line treatment at progression.»

Adds Tsvetkov: «We know a mechanism of resistance now.

What's interesting is the mechanism of resistance to PPOs.

To prevent this mechanism of resistance and block the B - cell receptor signaling at its root, Elena Battistello, the PhD student who led this project, targeted the three enzymes (LYN, FYN, and BLK) that initiate the propagation of the signals.

«Professor Mobashery has been working on the mechanisms of resistance in MRSA for a very long time,» Chang said.

«This may be compensatory and a mechanism of resistance to anti-psoriasis therapy, and it suggests that the solenopsin compounds could be used in combination with existing approaches,» Arbiser says.

But we need to be prepared for the mechanism of resistance and for the likelihood of making the cancer more aggressive,» Crawford says.

Without explicitly looking for it, Katherine Nathanson, MD, a professor of Medical Genetics and director of Genetics at the Basser Center, found another mechanism of resistance to DNA damaging agents.

However, sooner or later, insect species may be able to develop a mechanism of resistance against any pesticides.

The researchers, including scientists from pharmaceutical company AstraZeneca, report in an advanced online publication in Nature Medicine on May 4, that their findings indicate «an underappreciated genomic heterogeneity» in mechanisms of resistance to tyrosine kinase inhibitor (TKI) drugs that target the Epidermal Growth Factor Receptor (EGFR) mutation that drive some cases of non-small cell lung cancer (NSCLC).

Additional studies in which we more precisely define the mechanisms of resistance and growth in an individual's tumor with genomic sequencing, and other means, will be important to maximize the ability to target all the critical pathways to achieve greater success.»

The researchers also suggest further research on the mechanisms of resistance and cross-resistance within the flea vector, to gain a fuller understanding of how insecticide develops and spreads across populations.

Uncovering their mechanisms of resistance could reveal new molecular pathways to target with antibiotics.

New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.

We need to understand the mechanisms of resistance to PARP inhibitors to potentially identify patients who are going to recur quickly and who will not benefit significantly from them.

Previosly in a preclinical study BRAF inhibitor - resistant mutated BRAF melanoma cells were developed as an experimental model system to mimic BRAF inhibitor - resistant melanoma patients and to study the mechanisms of resistance.

BRAF mRNA alternative splicing is a mechanism of resistance to targeted therapy.The aim of this study is to evaluate the impact of alternative splicing in patients treated with BRAF and MEK inhibitors and to assess the efficacy of splicing modulators in overcoming this resistance mechanism.

«Numerous pre-clinical studies have now shown a requirement for autophagy in sustaining tumor growth, including pancreatic cancer, as well as in providing a mechanism of resistance to a number of currently used therapies» said Kimmelman.

Our laboratory works to understand the mechanism of resistance to anticancer drugs observed in many human cancers.

This target identification platform is used to identify novel targets and rational combinations and mechanisms of resistance to our current programs.

«We need to understand the mechanism of resistance but also to understand what causes resistance to emerge in some places and not others.