Sentences with phrase «mechanisms during the differentiation»

Not exact matches

Up until now, however, it has been unclear what comes first during cardiomyocyte differentiation: the reorganization of the DNA's folding in the cellular nucleus or the DNA's methylation — and whether these mechanisms are dependent on one another.

The scientists conclude that the study reveals an essential function for CTCF in the orchestration of transcriptional changes during the terminal differentiation of B lymphocytes and advances understanding of the mechanisms that regulate the immune response.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

In parallel, the roles of symmetric and asymmetric cell divisions are investigated as a mechanism for governing stem cell self - renewal and differentiation during embryonic development and in the adult.

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).

During embryonic development, neurogenesis proceeds maintaining a fine balance between mechanisms that support self renewal of undifferentiated radial progenitors and others that instruct precursors to commit to specific fates and achieve terminal differentiation.

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.