Research activities are also concentrated on the identification of disease
mechanisms in vertebrates with the ultimate goal to identify molecular targets and cells with therapeutical potential.
Not exact matches
Several of the network genes Volkan and her team identified have counterparts
in humans and other
vertebrates, which suggests the same basic
mechanism could be at work
in building the nervous system
in other animals too.
«The fundamental
mechanisms are probably going to be the same
in all
vertebrates, as even frogs and fish have gaze control,» Knudsen says.
«Given the similarities
in the molecules and the
mechanisms involved
in limb development
in vertebrates and invertebrates, the fly is a very useful genetic model
in which to identify new genes that potentially participate
in limb development
in vertebrates and their possible association with congenital diseases,» says Ana Ferreira, who has participated
in the study.
On page 812 of this issue, Sallan and Galimberti (1) show that trends
in the body sizes of
vertebrates during the Devonian and Mississippian (about 420 to 325 million years ago) not only are markedly different at different times but also likely reflect a variety of different evolutionary
mechanisms.
In the brains of all
vertebrates, information is transmitted through synapses, a
mechanism that allows an electric or chemical signal to be passed from one brain cell to another.
Drosophila serves as a model organism that helps geneticists to decode the molecular fundamentals of cellular biology and unravel
mechanisms that are conserved
in human beings and other
vertebrates.
The
mechanism stems from the vestibular system — structures
in the inner ear that help
vertebrates balance, sense movement and determine their position
in space.
«Similar
mechanisms are present
in vertebrates and flies,» Andretic told me.
From an evolutionary perspective, the findings reveal that sophisticated immune defense
mechanisms in respiratory surfaces came about very early
in vertebrate evolution.
«There has been a lot of recent research showing that these behaviors — like aggression or reproduction or parental care — are sort of ubiquitously distributed across
vertebrates, and the
mechanisms that promote and maintain those behaviors are similar
in all species,» DeAngelis said.
«Branchial rays will figure prominently
in the story of the evolutionary origin of
vertebrate animal appendages, either by shedding light on the evolutionary antecedent of paired fins / limbs, or by teaching us about the genetic
mechanisms that animals can use to invent new appendages,» Gillis says.
«This is an exciting finding, because it indicates that the molecular
mechanisms underlying the segmentation clock are really quite ancient,» says David Turner, a neurobiologist at the University of Michigan, Ann Arbor, who studies Notch
in vertebrates.
«Parasitic fish offer evolutionary insights:
Vertebrates once might have relied on a different
mechanism for developing neurons
in the gut.»
Lamprey show that
vertebrates once might have relied on a different
mechanism for developing neurons
in the gut.
«Our study reveals a spectrum of methods that nature uses to allow organisms to adapt to different environments,» said senior author Kerstin Lindblad - Toh, Scientific Director of
Vertebrate Genome Biology at the Broad Institute: «These
mechanisms are likely to be also at work
in humans and other
vertebrates, and by focusing on the remarkably diverse cichlid fishes, we were able to study this process on a broad scale for the first time.»
Dr. Jessell, the Claire Tow professor
in the departments of Neuroscience and Biochemistry & Molecular Biophysics at Columbia University, was selected for his pioneering work
in discovering the principles of the molecular
mechanisms that direct neuronal diversity and circuit assembly
in the
vertebrate central nervous system.
A new study from SciLifeLab / Uppsala University published
in PLOS ONE shows that genes crucial for vision were multiplied
in the early stages of
vertebrate evolution and acquired distinct functions leading to the sophisticated
mechanisms of
vertebrate eyes.
«Our study reveals a spectrum of methods that nature uses to allow organisms to adapt to different environments,» said co-senior author Kerstin Lindblad - Toh, Co-Director of SciLifeLab, scientific director of
vertebrate genome biology at the Broad Institute and professor
in comparative genomics at Uppsala University «These
mechanisms are likely also at work
in humans and other
vertebrates, and by focusing on the remarkably diverse cichlid fishes, we were able to study this process on a broad scale for the first time.»
«Drosophila approximates many of the fundamental
mechanisms of early development
in vertebrates,» Bonini says.