Sentences with phrase «mechanisms of cancer cell»

The researchers are reporting preclinical findings for a potential two - treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual...

Almost every mechanism of cancer cells tested was reported to be affected by these drugs, a phenomenon hardly to be traceable back to one or a few underlying molecular targets.

As the studies summarized above suggest, the mechanism of cancer cell death caused by selenium is its ability to increase extracellular glutathione, an antioxidant that plays a role so critical in eliminating toxins from the body, that Dr. Mark Hymann has called it «the mother of all antioxidants».

Not exact matches

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).

The findings, published in Proceedings of the National Academy of Sciences (PNAS), define a mechanism in which the oncogenes turn on a protein called RSK2 that is required for cancer cells to move.

Seeking one mechanism to explain the induction of cancer by many different agents, Huebner and Todaro had suggested that retrovirus oncogenes are a part of the genetic baggage of all cells, perhaps acquired through viral infection early in evolution.

The Cent - 1 molecule kills cancer cells through a mechanism similar to that of the template drug Rigosertib that is currently under commercial development.

«We've long known that NF - kB promotes cancer development by subverting apoptosis, an internal safety mechanism that otherwise would cause cancer cells to self - destruct,» says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and of molecular and cellular biochemistry.

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibCancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibCancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibcancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cCancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast ccancer cells that leads to chemotherapy resistance in inflammatory breast cancercancer.

Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

«Our work suggests a mechanism for cell lethality involving the regulation of BCAAs as crucial elements in pancreatic cancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD Andcancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD AndCancer Biology, senior author of the Nature paper and president of MD Anderson.

Adult drug resistant cancer cells may contribute to this problem, and the authors discuss these and other cancer drug resistance mechanisms in their recent publication in the September issue of the journal Cancers.

«Further research into the detailed mechanisms underlying ASIS in naked mole - rats may shed new light on cancer resistance in the mole - rats and contribute to the generation of non-tumorigenic human - iPSCs, enabling safer cell - based therapeutics,» said Kyoko Miura, an assistant professor at Hokkaido University.

Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic stratCell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic stratcell autodigestion as a potential therapeutic strategy.

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.

The drug's mechanism of action was entirely new: Instead of attacking cancer cells (like chemo), or indiscriminately revving up the immune system (like IL - 2), ipilimumab blocked a single receptor on one type of immune cell.

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasicancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer MetastasiCancer Metastasis Lab.

These techniques are key to understanding the molecular mechanisms underlying cell function in healthy and diseased individuals and the development of diseases like cancer.

The work also reinforces the importance of finding tumor cell clusters in the blood as a mechanism of detecting cancer metastasis earlier.

However, the mechanisms by which tumor cells interact to enhance the spread of cancer remained unclear.

University of Alberta researchers have discovered a mechanism that may make cancer cells more susceptible to treatment.

«This remodeling process of the cell proteome by autophagy is an important immune - suppressive survival mechanism for Ras - driven cancers, and inhibiting autophagy can provide a means to target these aggressive cancers,» notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.

«These findings build on a long history of work in our laboratory investigating mechanisms by which cancer cells respond to environmental stresses,» says Grant.

The phenomenon, known as Warburg effect, is typical for cancer cells and the mechanism behind is believed to benefit cancer cells by switching biochemical engines from energy manufacturing reactions to anabolic reactions, which primarily support growth of the cell size and proliferation.

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patCancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patcancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

«We challenged a current dogma in the field that emphasized PLK1's role in mitosis (cell division) as a primary mechanism for cancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medcancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of MedCancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of MedCancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medicine.

Understanding the physiological mechanisms that cause or, as in this case, prevent genetic instability is a basic question in Molecular Biology and Biomedicine which is of vital importance in the research against cancer, given that genetic instability is a distinctive feature of tumorous cells.

UCLA scientists have unlocked an important mechanism that allows chemotherapy - carrying nanoparticles — extremely small objects between 1 and 100 nanometers (a billionth of a meter)-- to directly access pancreatic cancer tumors, thereby improving the ability to kill cancer cells and hence leading to more effective treatment outcome of the disease.

While further research is needed to understand the effectiveness of H1.0 protein in preventing the spread of cancer growth, this research advances significantly the study of the mechanisms of cancer stem cells and the relatively new epigenetic approach to cancer research.

He then studied cancer cell signaling, discovering mechanisms of sensitivity and resistance to targeted agents.

Further investigations could pave the way to a more complete understanding of the genetics and metabolomics of cell growth in yeast and the underlying mechanisms relevant to other settings in which cells face challenging conditions, such as cancer progression and the evolution of drug resistance.

An international study led by scientists from the Crick Institute in London and the Hebrew University of Jerusalem revealed a survival mechanism in cancer cells that allows the disease to erupt again even after aggressive treatment.

This research has the potential to rapidly reduce breast cancer mortality by mimicking these mechanisms with new drugs and improving prediction of when cancerous cells will grow or metastasize.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

Are there any other ways to strike at the fundamental mechanisms that trigger growth of cancer cells?

Researchers from the University of Missouri School of Medicine have identified a molecular mechanism that operates in memory T cells that could be manipulated to produce and maintain more memory T cells in the body, a finding that could improve vaccinations and cancer immunotherapies.

In one of nature's mixed blessings, the mechanisms that work to heal cuts and wounds, rebuilding damaged cells, can also go out of control and cause cancer.

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

Now, researchers from the University of Missouri School of Medicine have identified a molecular mechanism that operates in memory T cells that could be manipulated to produce and maintain more memory T cells in the body, a finding that could improve vaccinations and cancer immunotherapies.

The mechanism that becomes effective is a destructive signal sent by the antibody to the inside of the cancer cell and initiates its death.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

A novel mechanism — similar to how normal tissue stem cells respond to wounding — might explain why bladder cancer stem cells actively contribute to chemo - resistance after multiple cycles of chemotherapy drug treatment.

Tadashi Matsuda of Hokkaido University and his colleagues in Japan investigated human prostate cancer cells to determine if there is an unknown up - regulation mechanism in the EGFR pathway.

For years, attempts have been made to understand the mechanism behind the proliferation of cancer cells: they need metabolites to grow and proliferate as much as a vehicle needs gasoline or electricity to move.

Cancer tumours manipulate a natural cell process to promote their survival suggesting that controlling this mechanism could stop progress of the disease, according to new research led by the University of Oxford.