Sentences with phrase «mechanisms of cancer growth»

Not exact matches

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibCancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibCancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibcancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

«Next steps are to further explore this possibility in human trials in order to assess if it will help patients, but these two drugs make sense from a variety of studies and we find that they act together through multiple mechanisms to control cancer growth in the laboratory.»

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasicancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer MetastasiCancer Metastasis Lab.

Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (EGFR).

The phenomenon, known as Warburg effect, is typical for cancer cells and the mechanism behind is believed to benefit cancer cells by switching biochemical engines from energy manufacturing reactions to anabolic reactions, which primarily support growth of the cell size and proliferation.

A breast cancer therapy that blocks estrogen synthesis to activate cancer - killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (cancer therapy that blocks estrogen synthesis to activate cancer - killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (cancer - killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (Cancer Institute (UPCI).

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patCancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patcancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

«We challenged a current dogma in the field that emphasized PLK1's role in mitosis (cell division) as a primary mechanism for cancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medcancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of MedCancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of MedCancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medicine.

While further research is needed to understand the effectiveness of H1.0 protein in preventing the spread of cancer growth, this research advances significantly the study of the mechanisms of cancer stem cells and the relatively new epigenetic approach to cancer research.

Further investigations could pave the way to a more complete understanding of the genetics and metabolomics of cell growth in yeast and the underlying mechanisms relevant to other settings in which cells face challenging conditions, such as cancer progression and the evolution of drug resistance.

Are there any other ways to strike at the fundamental mechanisms that trigger growth of cancer cells?

In particular, he wanted to study the genomes of marbled crayfish to uncover basic mechanisms underlying epigenetics, the binding of molecules to DNA that can drive tumor growth and help cancer spread.

She says they can now identify the mechanisms that cause tumor growth in half of all adenocarcinomas, a family of cancer that affects skin and other tissue, including the lungs.

Biochemist Valerie Weaver of the University of California, San Francisco, who led previous studies linking tissue stiffness and breast cancer growth, calls the paper «very important» because it finds a novel mechanism linking obesity with breast cancer.

The researchers, including scientists from pharmaceutical company AstraZeneca, report in an advanced online publication in Nature Medicine on May 4, that their findings indicate «an underappreciated genomic heterogeneity» in mechanisms of resistance to tyrosine kinase inhibitor (TKI) drugs that target the Epidermal Growth Factor Receptor (EGFR) mutation that drive some cases of non-small cell lung cancer (NSCLC).

«Researchers inhibit tumor growth in new subtype of lung cancer: Insight into tumor suppressing and tumor promoting mechanisms offers potential for new treatments.»

Zhang's laboratory now seeks to understand the mechanisms of the tissue - environment influence, opening the possibility that the environment could be altered in a way that fights cancer by preventing tumor cell growth.

These include, for example, the mechanisms behind stem - cell development and what happens when normal cellular growth spirals out of control, such as in cancer.

Published in the May 1 edition of Cancer Research, the study supports a critical role for IGF - 1R signaling in prostate - tumor development and identifies an important IGF - 1R - dependent growth control mechanism, according to the authors.

Many cancers are still difficult to treat and development of drugs exploiting new pathways and mechanisms involved in tumor initiation and malignant growth is of high priority [1].

Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert in tumor vasculature, to investigate the virus's mechanism of action in animal models.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

The acquisition of growth signal self - sufficiency is one of the hallmarks of cancer.28 In this paper, we show that a broad spectrum of spontaneous mutations in one of the endogenous JAK1 alleles is the main mechanism that confers to BaF3 cells cytokine - independent growth capability in vitro and full tumorigenicity in vivo (Online Supplementary Figure S5), secondary to the upregulation of the JAK1 transcript.

Specifically, my research proposal addresses the mechanisms by which the kinase 3 - phosphoinoside dependent protein kinase - 1 (PDK1) mediates resistance to cell cycle related CDK4 / 6 inhibition in ER + breast cancer and explores the in vivo effects of inhibiting PDK1 in combination with CDK4 / 6 inhibitors toward ER + breast cancer growth.

It's considered that this is a component of the mechanism driving out of control cell division and cancer growth.

A number of the mechanisms which help prevent abnormal cell growth are avoided in cancer cells.

What is the mechanism by which our diet can affect our levels of this cancer - promoting growth hormone IGF - 1?

http://nutritionfacts.org/video/animal-protein-compared-cigarette-smoking/ If you watch the series of videos on NutritionFacts about IGF - 1, you will learn one mechanism on how / why animal based proteins contribute to cancer growth..

Researchers were able to demonstrate the mechanism by which a plant - based diet and exercise could suppress the growth of breast and prostate cancer cells and protect against prostate enlargement (more on prostate problems in Some Prostates are Larger Than Others and Prostate Versus Plants).

Avocado helps prevents the growth of cancer while supporting the body's natural defense mechanisms.

EPA has potent anti-inflammatory properties, helps thin blood, and prevent the growth of new blood vessels (one mechanism of how cancer spreads).

Viewing cancer as a metabolic disease — opposed to a disease of damaged DNA, which is a downstream effect of mitochondrial dysfunction — gives us the power to control this dysfunction by carefully choosing foods and nutrients and employing strategies that help optimize the biochemical pathways that suppress cancer growth while simultaneously stimulating mechanisms to push it into remission.

While the exact mechanisms are still unknown, vitamin D has been shown to lower blood pressure, increase flexibility of blood vessels, inhibit cancer cell growth and reduce whole - body inflammation.

Polyunsaturated fats such as corn oil and soybean oil are highly unstable and vulnerable to oxidation — and oxidation, in turn, is linked to cancer — while the omega - 6 fatty acids that predominate in vegetable oils have been shown to accelerate the growth of tumor cells.6 As Fallon and Enig explain, 4 excessive consumption of toxic polyunsaturated oils — not red meat — represents a known mechanism for colon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis added].

As such, another mechanism for the ketogenic diet working within brain cancer is the ability of the ketone bodies to enhance the protection of healthy central nervous system (CNS) from cancer growth (11).

That is, simple adjustment of dietary protein (casein) within very normal ranges of protein intake controlled cancer growth and it worked not by one mechanism but by a large array of mechanisms.