This classic work has inspired several generations of scientists to discover
mechanisms of cell identity, which have informed a lot of the discoveries in stem cell biology and reprogramming that have followed.
Not exact matches
A very interesting finding was that this
mechanism is important for maintaining the
identity of the
cells.
Although the functional importance
of TCF - 1 in T
cells has been known for more than 25 years, the
mechanism by which this protein controls T -
cell identity remained unknown.
One is straightforward — during development,
cells are assuming their
identities and need precise control over protein production, so
cells lacking a gene expression regulation
mechanism are bound to have defects, particularly in the case
of specialized
cells like neurons.
The fellow will drive a new project focusing on molecular
mechanisms controlling the
identity, self - renewal, and differentiation potential
of skeletal stem
cells.