This discovery will help to illuminate the
underlying mechanisms of diseases that start with mutations in mitochondrial DNA and provide clues about how patients might respond to specific treatments.
Scientists in our group combine methods development, data generation and analysis with hypothesis generation and experimental testing to obtain insights into
biological mechanisms of disease.
Having this wealth of information and insight into the
genetic mechanisms of disease offers now the possibility of advancing medicine and basic research in ways that were not available before.
Amgen's approach is to understand the fundamental biological
mechanisms of disease in order to determine what type of medicine is most likely to deliver optimal efficacy and safety.
The researchers also found the likely
mechanism of disease progression in the Tob1 - deficient mice: higher levels of Th1 and Th17 cells, which cause an inflammatory response against myelin, and lower levels of Treg cells, which normally regulate inflammatory responses.
Tanksley, Martin and other Ithaca scientists developed genetic maps and other molecular tools for tomatoes to
study mechanisms of disease resistance, and those tools ultimately paved the way for the consortium's sequencing efforts.
The Department of Veterinary Pathobiology (VTPB) focuses
on mechanisms of disease including host / pathogen interactions, ecology of antimicrobial resistance, genetics of disease susceptibility and resistance, wildlife diseases, and conservation genetics.
Tuncay Baubec, professor at the Department of Molecular
Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA.
The lead author is Nikolas Jorstad, a doctoral student in the Molecular Medicine and
Mechanisms of Disease program at the University of Washington.
Knowledge of the genetic background of Alzheimer's disease is crucial for finding new prevention measures and treatments, and for understanding the cellular
level mechanisms of the disease.
A $ 1.6 million effort to study the
complex mechanisms of the disease and identify existing drugs that might be able to be used for Alzheimer's treatment or prevention, led by Eric Schadt of Icahn School of Medicine at Mount Sinai in New York City.
Plowright et al. (2012) explain
numerous mechanisms of disease transmission and how they will interact with different species and in different locations.
We are studying the frequency of particular characteristics such as cancer diagnoses among those with PTEN alterations; working to clarify variants of uncertain significance; and exploring
alternative mechanisms of disease in patients without identified mutations.
For Swanton, «these studies led to the idea that integrating genomics and cell biology could start to
inform mechanisms of disease and ways to target those mechanisms with therapies.»
Fasano A, Shea - Donohue
T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases.
Her strong interest in toxicology and
mechanisms of disease led her to accept a position at the ASPCA Animal Poison Control Center where she was employed as a consulting veterinarian in Clinical Toxicology from 2007 - 2011.
This work integrates laboratory experiments, field observations, and spatially explicit modeling to explore
theoretical mechanisms of disease - induced extinction and the influence of fishing on the spread of disease.
One of the lessons of this research is that we have a new model animal to
study mechanisms of disease, and possibly discover new therapeutic agents.»
«With all our medications, we're attempting to develop an understanding of
the mechanism of the disease and an understanding of which patients will respond, so that we can treat those patients who will respond and not those who won't,» comments Richard Scheller, executive vice president of research for Genentech.
I think the findings have implications for understanding
the mechanism of the disease and developing new therapeutics.»
«Every time you find a gene, you have a new tool to work with, and it gives us insights into the underlying
mechanisms of disease,» says Gerard Schellenberg, a pathologist at the University of Pennsylvania who chairs the Alzheimer's Disease Genetics Consortium, a collaborative effort of investigators from 44 universities and research centers.
This basic fact makes it difficult for researchers to discern the underlying
mechanism of the disease: «It's very difficult to figure out what's wrong, because the bone marrow is nearly empty of these cells,» said Bessler, the director of CHOP's Pediatric and Adult Comprehensive Bone Marrow Failure Center.
However, many industry insiders say these changes are opening up unique opportunities for researchers who focus on translating basic science into real - world cures and are eager to explore the molecular
mechanisms of disease, test hypotheses, and do work that benefits patients.
But translation is not one - way; the insights gained at the bedside, and from clinical and population - based studies, will spawn hypotheses, enabling scientists to probe
the mechanisms of disease in new ways and ultimately enriching basic biology.
Once they found that the OTULIN gene was abnormal in the sick children, they studied the immune pathway in order to understand
the mechanisms of disease and to improve treatment of these patients.
Not long after the IOM report was published, NIH issued its own written assessment, concluding that research has neglected many of the biological factors behind ME / CFS and urging more basic science aimed at teasing out
the mechanisms of the disease.
Kathleen Kelly, a cancer biologist at NCI, is optimistic that the work will enhance understanding of the basic
mechanism of the disease.
Phrases with «mechanisms of disease»