Sentences with phrase «mechanisms of disease in»
Mechanisms of disease in small animal surgery.
https://www.cuvs.org/
Amgen's approach is to understand the fundamental biological mechanisms of disease in order to determine what type of medicine is most likely to deliver optimal efficacy and safety.
But translation is not one - way; the insights gained at the bedside, and from clinical and population - based studies, will spawn hypotheses, enabling scientists to probe the mechanisms of disease in new ways and ultimately enriching basic biology.
Not exact matches
These studies helped illuminate some of the molecular mechanisms by which these fungal pathogens cause disease in the banana.
Though the researcher said there needs to be more research into the exact mechanisms of why that is, they concluded that «healthy sleep appears to play an important role in maintaining brain health with age, and may play a key role in [Alzheimer's disease] prevention.»
And a third, different kind of gene therapy from Spark Therapeutics — to treat a rare inherited form of blindness — is likely to be approved by the end of 2017, too, making this year a landmark for treatments that manipulate the body's own biological mechanisms in novel new ways to fight deadly diseases.
In those areas that we have mapped, it typically takes us a few hours to go from a mechanism - inspired idea for treating a disease to knowing the companies that might have relevant clinical and preclinical assets to license, the companies from whom a candidate could be commissioned, trial designs and endpoints, competing and complementary agents, current and future standard of care, market size, comparable pricing, financing strategy, and potential acquirers, all meant to enable a thoughtful first - pass assessment of whether an idea could be worth a much deeper assessment.
Minoryx harnesses its unique mechanism of action for potential use in X-ALD, a genetic disease characterized by progressive neurologic deterioration with no available pharmacological treatment.
«With the Immunoscape platform, we are seeking to develop a molecular map of inflammatory diseases that will help us identify and characterize disease mechanisms,» Jessica Mega, chief medical officer for Verily, said in Monday's announcement.
In May 2000, the Archives of Disease in Childhood published research showing that scrotal temperature is increased in boys wearing disposable diapers, and that prolonged use of disposable diapers will blunt or completely abolish the physiological testicular cooling mechanism important for normal spermatogenesiIn May 2000, the Archives of Disease in Childhood published research showing that scrotal temperature is increased in boys wearing disposable diapers, and that prolonged use of disposable diapers will blunt or completely abolish the physiological testicular cooling mechanism important for normal spermatogenesiin Childhood published research showing that scrotal temperature is increased in boys wearing disposable diapers, and that prolonged use of disposable diapers will blunt or completely abolish the physiological testicular cooling mechanism important for normal spermatogenesiin boys wearing disposable diapers, and that prolonged use of disposable diapers will blunt or completely abolish the physiological testicular cooling mechanism important for normal spermatogenesis.
«In order to make good therapies we have to understand the basic mechanisms of the disease,» McKee argued.
Interested in the fundamental biology of real - world problems, he accumulated a wide range of research skills to better investigate the molecular mechanisms at play in neurodegenerative diseases like Parkinson's and Alzheimer's.
«Indeed, we believe AR - V7 and other, related variants are a mechanism of resistance in this disease and patients who have them may have a poorer prognosis.»
The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.
«The discovery of HDMP in humans means that for the first time we are seeing an important mechanism in the process which causes the disease.
As pharmacologists, our interest is primarily in the mechanisms and therapeutics of ischemic heart diseases, and we have been working on the cardiovascular effects of herbs according to modern scientific criteria.
The work was on the role of interleukin - 1 in the pathology of graft - versus - host disease (GVHD), the mechanism by which the new immune system, which a patient receives as a bone marrow transplant, attacks the patient's body following the transplantation.
In precision medicine era legacy gifts of patient brain tissue reveal disease mechanisms and new therapeutic approaches
«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.
The existence of two mechanisms would make sense for what we know about biology: Salt is necessary for life, but too much salt can kill you, and not just in the sense that excess salt in the diet may be behind some cases of heart disease.
He concludes, «Mounting evidence from ecological and observational studies, as well as studies of mechanisms, indicates that the Western dietary pattern — especially the large amount of meat in that diet — is strongly associated with risk of developing Alzheimer's disease and several other chronic diseases.
«How the microbiome is linked to autoimmune disorders: Discovery of new mechanism in the gut microbiome has implications for inflammatory bowel disease.»
Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.
Gaining a better understanding of the underlying disease mechanisms could offer the possibility of developing new and better treatments for lupus and other autoimmune conditions in the future.
Tuncay Baubec, professor at the Department of Molecular Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA.
«Autophagy has crystalized as a common central mechanism of cellular quality control in neurodegenerative disease,» says Dikic.
«Dr. Murai and his team have made a remarkable discovery that will advance our understanding of fundamental mechanisms that play a role in brain disease,» says Inez Jabalpurwala, president and CEO of Brain Canada Foundation.
Disease - driving mechanisms vary and include, among others, the pruning of neuronal synapses, effects on CNS development in utero, and inflammation.
The findings highlight the need to evaluate a history of heart disease in the management of osteoporosis in older people and further research is also needed to provide a better understanding of the underlying mechanisms which explain the link between osteoporosis and heart disease.»
«The next step in understanding sleep apnea in the future will be to dissect different subtypes of sleep apnea, likely defined by distinct pathophysiological mechanisms which may underlie different outcomes and predisposition to comorbidities,» Cavadas says, «As human life expectancy increases, delaying the onset of age - related diseases becomes critical to our society.»
The next objective of the researchers is to decode the action mechanism of TREX2 in the development and maintenance of psoriasis, so as to design new therapeutic strategies for the treatment of this disease.
«We were very surprised to find alterations in proteins that are responsible for RNA splicing in Alzheimer's, which could have major implications for the disease mechanism,» says Allan Levey, MD, PhD, chair of neurology at Emory University School of Medicine and director of the Emory ADRC.
He finds «growing interest in industry to engage with universities to address basic research problems, to enhance basic knowledge of disease mechanisms.»
This mechanism may be involved in many more diseases,» explains study's co-author, Dr. David Rosenblatt, a scientist in the Child Health and Human Development Program at the RI - MUHC and holder of the Dodd Q. Chu and Family Chair in Medical Genetics in the Department of Human Genetics at McGill University.
The researchers caution, however, that it's not yet clear how closely the toxin - induced neural damage in rats mimics the state of diseased neurons in Parkinson's, especially because the mechanism that leads to such damage in humans remains unknown.
«The practice of the Wim Hof Method may lead to tonic changes in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from diseases of the immune system to more intriguingly psychiatric conditions such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.
He points out that some osteoarthritis sufferers have too much instead of too little pyrophosphate in their knee fluid, suggesting a different disease mechanism.
Understanding the mechanisms of inflammation in rheumatoid arthritis is important for the design of new therapies for this disease.
New research, led by scientists at the University of Southampton, has found that neurogenesis, the self - repairing mechanism of the adult brain, can help to preserve brain function in neurodegenerative diseases such as Alzheimer's, Prion or Parkinson's.
While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.
A better understanding of the molecular mechanism behind diseases and reduced body function might lead to improved drugs and therapies in the future,» says Åsa Johansson.
By pairing a receptor that targets neurons with a molecule that degrades the main component of Alzheimer's plaques, the biologists were able to substantially dissolve these plaques in mice brains and human brain tissue, offering a potential mechanism for treating the debilitating disease, as well as other conditions that involve either the brain or the eyes.
«Further work in our lab will be aimed at understanding the detailed mechanism of how these proteins regulate editing, in turn providing an inroad to developing therapeutics that modulate editing for the treatment of human diseases.»
Prof. Schuelke emphasizes: «Our results are a good example of how the study of rare genetic diseases can provide insights into general disease mechanisms, which may also play a role in other conditions, such as paraplegia, and which may give rise to the development of regenerative therapies.»
But a serendipitous discovery may someday give doctors a new countermeasure against the disease: Researchers report in tomorrow's Science that they have identified a possible mechanism of action for «lethal factor» (LF), a toxic protein produced by the anthrax bacillus that is thought to be one of the principal causes of death in infected individuals.
«We've got a new fundamental understanding of the pathological mechanisms in celiac disease, and it opens the possibility to develop new drugs against this disease,» says head of research, associate professor and ph.d., Thomas J. D. Jørgensen, Department of Biochemistry and Molecular Biology, University of Southern Denmark.
The prevention of dilated cardiomyopathy in a mouse model by feeding a high - fat diet signals an advance in the understanding of the mechanisms involved in heart disease and has implications for the future development of treatments for this condition.
«We see that two completely different disease entities share a common pathogenic mechanism,» said George Hajishengallis, a professor of microbiology in Penn's School of Dental Medicine and an author on the study.
He added Huntington's is one of many neurodegenerative diseases in which unusual protein deposition occurs in the brain, suggesting similar biochemical mechanisms may be involved.
«Dr. Thompson and his colleagues have provided new insight into the deep mechanisms of this terrible disease, and in doing so, they have created new avenues of research that have the potential to help millions of people.»