Sentences with phrase «mechanisms of disease led»
Her strong interest in toxicology and mechanisms of disease led her to accept a position at the ASPCA Animal Poison Control Center where she was employed as a consulting veterinarian in Clinical Toxicology from 2007 - 2011.
http://www.petpoisonhelpline.com/ Not exact matches
A research team from iMM Lisboa led by Luís Graça has found a cellular mechanism that underlies the development of autoimmune diseases.
Understanding this new mechanism of cardiovascular disease could lead to the development of new therapies to treat individuals who suffer from heart and blood vessel ailments due to these mutations,» explained corresponding author Kenneth Walsh, PhD, professor of medicine at BUSM.
The researchers caution, however, that it's not yet clear how closely the toxin - induced neural damage in rats mimics the state of diseased neurons in Parkinson's, especially because the mechanism that leads to such damage in humans remains unknown.
«The practice of the Wim Hof Method may lead to tonic changes in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from diseases of the immune system to more intriguingly psychiatric conditions such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.
New research, led by scientists at the University of Southampton, has found that neurogenesis, the self - repairing mechanism of the adult brain, can help to preserve brain function in neurodegenerative diseases such as Alzheimer's, Prion or Parkinson's.
While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.
A better understanding of the molecular mechanism behind diseases and reduced body function might lead to improved drugs and therapies in the future,» says Åsa Johansson.
«Mitochondrial «circuit breaker» protects heart from damage: Two newly identified mechanisms may lead to better understanding of disease, new treatments.»
The researchers conclude in their paper: «Ultimately, knowledge of the mechanisms by which thirdhand smoke exposure increases the chance of disease development in exposed individuals should lead to new strategies for prevention.»
The investigators suggest that the premature loss of estrogen caused by the oophorectomy may affect a series of aging mechanisms at the cellular and tissue level across the whole body leading to diseases in multiple systems and organs.
«It's really exciting that we have found a mechanism we can target to create new treatments for this devastating disease,» said lead investigator J. Timothy Greenamyre, M.D., Ph.D., Love Family Professor of Neurology in Pitt's School of Medicine and director of the Pittsburgh Institute for Neurodegenerative Diseases (PIND).
Once better understood, these genetic mechanisms may not only help to explain why not all of those who are obese develop related metabolic diseases, such as type 2 diabetes and high cholesterol, but could lead to possible ways to treat obesity or prevent metabolic diseases in those who are already obese.
UCLA scientists have unlocked an important mechanism that allows chemotherapy - carrying nanoparticles — extremely small objects between 1 and 100 nanometers (a billionth of a meter)-- to directly access pancreatic cancer tumors, thereby improving the ability to kill cancer cells and hence leading to more effective treatment outcome of the disease.
An international study led by scientists from the Crick Institute in London and the Hebrew University of Jerusalem revealed a survival mechanism in cancer cells that allows the disease to erupt again even after aggressive treatment.
For the study, Ho and Kosik, leading experts in Alzheimer's research, compiled a list of 64 conceivable approaches to drug discovery, addressing a range of biological mechanisms that may be involved in the disease.
Now, researchers may finally understand an important mechanism that keeps this friendly truce intact — a finding that may lead to the development of new therapeutic strategies for such chronic diseases.
«We expect our findings will lead to a better understanding of disease mechanisms and perhaps eventually help to identify new drug targets.»
The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»
«We continue to believe that mechanisms that combat aging in caloric restriction will offer a lead into drugs or other treatments to slow the onset of disease and death.»
«We have identified a new molecular mechanism which directly contributes to this synapse loss — a discovery we hope could eventually lead to earlier diagnosis of the disease and new treatments.»
Dr Alexander Mazein, lead author of the study from the European Institute for Systems Biology and Medicine, commented: «In - depth understanding of asthma means redefinition of asthma subtypes based on the mechanisms that lead to the development of the disease.
«Understanding the principles and mechanisms involved in neuronal homeostasis may lead to new approaches in the treatment of these and other brain disorders like Alzheimer's disease.»
Cancer tumours manipulate a natural cell process to promote their survival suggesting that controlling this mechanism could stop progress of the disease, according to new research led by the University of Oxford.
Understanding the dynamic mechanisms that lead to the emergence of brain functions through the development and continuous remodelling of neural circuits, and the constraints that disease and aging impose to this multi-modal plasticity has important implications that go beyond fundamental neuroscience, from education policies to brain repair.
The mechanism is thought to be similar to that of the human spliceosome whose malfunctioning can lead to several diseases among which neurodegeneration and cancer.
A $ 1.6 million effort to study the complex mechanisms of the disease and identify existing drugs that might be able to be used for Alzheimer's treatment or prevention, led by Eric Schadt of Icahn School of Medicine at Mount Sinai in New York City.
«We've identified a novel molecular mechanism that regulates energy expenditure and may help prevent obesity and the metabolic syndrome,» says lead author Bernat Baez - Raja, PhD, a research scientist in the Gladstone Institute of Neurological Disease.
«Understanding these mechanisms in vivo would allow for targeted blockade of bacterial transport via vaccinations or medications, which could ultimately lead to new ways to prevent or treat airway infectious diseases,» Dr. Shiloh explained.
New research led by Harvard School of Public Health (HSPH) demonstrates a disease mechanism in type 1 diabetes (T1D) that can be targeted using simple, naturally occurring molecules to help prevent the disease.
The findings, published in the journal ACS Central Science, shed new light on the underlying mechanisms of CF and could lead to improved prognosis and better therapies for a disease which is quite variable, affecting different children in different ways, say researchers.
Molecular microbiologists at the University of Southern California (USC) have uncovered intricate regulatory mechanisms within the cell that could lead to novel therapeutics for the treatment of cancer and other diseases.
A detailed analysis of this mechanism will be crucial to understand how aggregate - forming proteins lead to human diseases and may help to develop concepts for possible disease preventions.
A team of researchers from Bern has now obtained valuable insights into this vital mechanism that could lead to new therapeutic approaches for genetic diseases.
In this review topic, researchers looked at novel translational noise studies demonstrating the molecular mechanisms that may lead to impaired vascular function, recent epidemiologic evidence of noise - induced cardiovascular disease, and the non-auditory effects of noise and their impact on the cardiovascular system.
Noise may disrupt the body on the cellular level in a way that increases the risk of common heart disease risk factors, according to a review topic published today in the Journal of the American College of Cardiology that examined the underlying mechanisms that may lead to noise - induced heart disease.
Scientists have identified the molecular mechanism that leads to the death of neurons in amyotrophic lateral sclerosis (also known as ALS or motor neurone disease) and a common form of frontotemporal dementia.
Further experiments in yeast and mice along these lines led Lindquist to propose a new, unifying hypothesis to explain the origin of the human prion disease and the mechanism of its toxicity.
Djimdé leads a research group at the University of Science, Techniques and Technologies of Bamako that is working to understand how genome variation in the Plasmodium falciparum parasite, its human host, and the Anopeheles gambaie mosquito vector contribute to the mechanisms of malaria disease spread.
This multidisciplinary analysis provides the blueprint for a detailed understanding of complex biological processes, the pathogenic mechanisms leading to diseases such as cancer, autoimmune or genetic diseases.
Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease.
He has led a well - regarded basic research program into mechanisms of plant disease and plant disease resistance, for which he was elected EMBO member in 1999 and FRS in 2003.
To cite a few instances, polymerase chain reaction (PCR), a molecular method developed over three decades ago, has been widely applied in disease diagnosis, disease mechanism deciphering, and prognosis prediction; the elucidation of tyrosine kinase activity in cancer cells has led to the development of novel drugs for cancer treatment; and the identification of proteins and genetic molecules by molecular methods as biomarkers for disease diagnosis and prognosis has been drawing great interest.
Overall, this simple technique (see figure for overview) produces therapeutically relevant cells in a safe and efficacious manner, which may be used in in vitro models for the investigation of glaucoma disease mechanisms, RGC development, drug testing, and may in the future lead to a treatment of glaucomatous neuropathy.
«The finding that certain variants of the PKP - 2 gene may increase the risk of developing the disease opens new possibilities in understanding the disease mechanism leading to atopic dermatitis,» continues Katarina Tengvall.
A UC San Francisco - led research team has identified the likely genetic mechanism that causes some patients with multiple sclerosis (MS) to progress more quickly than others to a debilitating stage of the disease.
I look for genes, pathways, and candidate mutations associated with a disease, in order to understand the mechanism and the etiology of a disease, which may eventually lead to new therapeutic targets.
«The Buck Institute has an excellent track record of training and preparing leading researchers in the mechanisms of biological aging and its relationship to chronic disease,» said Mark Collins, President of the Glenn Foundation for Medical Research.
It took eight long years of research, but now an international team led by neuroscientists at Université de Montréal has discovered a basic molecular mechanism that better helps understand how Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), works.
Well, we really don't know at this time, but based on some of the studies done, it appears that both can occur simultaneously, but depending on the mechanism leading to metabolic disease it can involve one or both pathways.