Sentences with phrase «mechanisms of diseases associated»

Geriomics: IFAR has one of the only scientific programs in the U.S. dedicated to studying the genetic mechanisms of diseases associated with old age.

Not exact matches

He concludes, «Mounting evidence from ecological and observational studies, as well as studies of mechanisms, indicates that the Western dietary pattern — especially the large amount of meat in that diet — is strongly associated with risk of developing Alzheimer's disease and several other chronic diseases.

«We've got a new fundamental understanding of the pathological mechanisms in celiac disease, and it opens the possibility to develop new drugs against this disease,» says head of research, associate professor and ph.d., Thomas J. D. Jørgensen, Department of Biochemistry and Molecular Biology, University of Southern Denmark.

Genotoxicity is associated with the development of diseases and is a critical mechanism responsible for many types of cancer caused by smoking and secondhand smoke exposure.

She earned a Ph.D. from the University of Southern California in which she characterized the mechanisms of sex hormone - induced neuroprotection against apoptosis associated with Alzheimer's disease (AD).

«Our study highlights the sensory aspects of basal ganglia function and presents a new approach to the mechanisms behind the sensory impairments seen in Parkinson's disease,» says Gilad Silberberg, associate professor at Karolinska Institutet's Department of Neuroscience.

While the mechanism by which a significant weight loss can reduce asthma - associated risks is unknown, studies have linked obesity to increased inflammation, higher prevalence of gastroesophageal reflux disease, and physical changes in the airway — all of which could contribute to asthma severity.

Exposure to a group of common pesticides, called dithiocarbamates, has long been associated with an increased risk of Parkinson's disease, although the mechanism by which the compounds exert their toxicity on the brain has not been completely understood.

Particulate matter in the body, such as the cholesterol crystals associated with vascular disease and the amyloid plaques that form in the brain in Alzheimer's disease, can also cause inflammation but the exact mechanism of action remains unclear.

«Knowing this mechanism that underlies IL - 37's effect on the immune system now allows us to study IL - 37 function and perhaps dysfunction in a wide range of diseases,» says Mayumi Fujita, MD, PhD, investigator at the University of Colorado Cancer Center, associate professor in the CU School of Medicine Department of Dermatology, and the paper's senior author.

The strategy of drug discovery may correct defects associated with genetic diseases as it continued to I - Stem is based on the access that pluripotent stem cells provide molecular mechanisms involved in these diseases.

His research has also discovered a novel mechanism to regulate neurotrophic growth factor - associated signaling pathways by miRNAs in context of PD and Alzheimer's disease (AD), and a role of dysfunctional bioenergetics in the pathogenesis of late - onset AD.

Conclusions: The identification of gene expression alterations as a function of hypoxia and recovery from hypoxia is important to understand the molecular mechanisms underlying retinal dysfunction associated with a variety of diseases.

«In our lab, we investigate the brain mechanisms behind drug addiction — a common and devastating disease with limited treatment options,» explained Christopher Cowan, PhD, director of the Integrative Neurobiology Laboratory at McLean and an associate professor of psychiatry at Harvard Medical School.

Mechanisms that link tumor suppression and the development of cancer to aging and the major diseases associated with aging

Elucidating the functional consequence of genetic variants associated with disease provides essential insights into the molecular mechanisms that define human traits.

I look for genes, pathways, and candidate mutations associated with a disease, in order to understand the mechanism and the etiology of a disease, which may eventually lead to new therapeutic targets.

Scott Henderson, who has been directing microscopy core facilities for nearly 25 years, loves to talk about how such facilities help scientists explore essential cellular functions and gain a better understanding of the mechanisms associated with disease.

«Just because a drug is new or exploits a new mechanism does not mean that it adds clinically to treating particular diseases,» said co-author Randall Stafford, MD, PhD, associate professor at Stanford University School of Medicine.

Such treatments, if discovered, could counter not only the effects of mutations in SLC16A11, but also potentially any T2D - associated variants that may trigger the disease through similar mechanisms.

The second area is pharmacology based on automated screening of large libraries of compounds with therapeutic potential, following modeling of molecular mechanisms associated with diseases, as revealed by the study of pluripotent stem cells from affected donors.

Current research on aging has largely focused the molecular mechanisms of age - related diseases, and mitochondrial dysfunction has been associated with several human diseases of aging.

The new mechanism of cooperation reported might be implicated in protection against asthma, allergies and immune - mediated diseases that has been associated with a carrier state,» said Raquel Hontecillas, associate professor of immunology, NIMML co-director, and corresponding author of the publication.

It would allow us to identify which genes associated with disease are active in our bodies and where, and analyze the regulatory mechanisms that govern the production of different cell types.

Intersection of immunogenomic resources with disease associated variants paints a detailed picture of disease causal mechanisms.

However, since most of the disease variants fall outside the gene coding sequences, thereby implicating gene expression regulation as the causal mechanism, the functional interpretation of the exact role of the associated variants remains to be determined.

Although next - generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge of the functions and pathobiological mechanisms of most genes.

Her research interest is in neurodegenerative disease, specifically in the synaptic loss associated with Alzheimer's disease, and mechanisms of learning, memory, and consciousness.

A new five - year grant from the National Eye Institute totaling $ 2,187,500 to Jackson Laboratory (JAX) Associate Research Scientist Krish Kizhatil, Ph.D., will support research into mechanisms of glaucoma, an eye disease expected to affect 80 million people by the end of the decade.

Cellect; is there an adequate amount of iodine Dr David Brownstein MD author of «Iodine Why You Need It» The Iodine study involving over 4,000 cases revealing Iodine and cancer Dr Kelley's three trigger mechanisms of cancer Breast cancer and the iodine relationship Chronic illness, health issues and symptoms associated with an iodine deficiency Fibrocystic breast disease, cyst formation and enzyme supplementation Severe headaches and migraines Why won't my PH balance?

These observed associations, albeit generally modest, may represent a pathophysiologic mechanism for the pleiotropic effects of magnesium intake on the features of the metabolic syndrome and its associated chronic diseases.

«Future research will reveal the molecular mechanisms behind this immediate stress response and elucidate its role in the development of diseases associated with chronic sleep loss,» said Katrin Ackermann, PhD, the study's lead author.

The end result of these two mechanisms is that much more of the statin drug enters the systemic circulation than would normally be the case, leading to a build up in statin levels that can be quite dangerous, and may trigger a rare but serious statin - associated disease called rhabdomyolysis.

These processes of «senescence - induced senescence» and «inflammation - induced inflammation» appear to be important mechanisms in aging and the induction and progression of neurodegeneration and other age - associated diseases.»

• explore multiple biological responses to chronic stress (e.g. elevated inflammation, accelerated atherosclerosis, and increased insulin resistance) to elucidate causal mechanisms of adult diseases that are associated with adverse childhood experiences.

Rick earned a Master of Science degree in Plant Pathology from Cornell University in 2012 and, under the advisement of Dr. Eric Nelson, conducted research on understanding the mechanisms associated with vermicompost - mediated disease suppression.