Sentences with phrase «mechanisms of gene»

Mechanisms of gene - environment interactions in depression: evidence that genes potentiate multiple sources of adversity

Conclusion: These findings highlight innovations specifically evolved in platyhelminths presumably associated with novel mechanisms of gene expression regulation mediated by small RNA pathways that differ to what has been classically described in model organisms.

The main research focus of the single molecule group is the study of molecular motors, the role of force in regulating biological systems, and the molecular mechanisms of gene expression regulation.

Ana got her PhD at ICGEB and Osaka University on strategies for optimization of HBsAg expression in Pichia pastoris under the direction of Dr. Navin Khanna, and she did postdoctoral work woth Prof. Rolf Jessberger at Mount Sinai School of Medicine in New York where she carried out a project aimed at deciphering the mechanisms of gene targeting by recombinant adeno - associated virus in human cells.

«This is the first method that accounts for the mechanisms of gene regulation, and can be applied to any heritable disease or phenotype.»

As a researcher of the molecular mechanisms of gene transcription, Sampley Bohn conducted her postdoctoral research at the National Institutes of Health in the National Institute of Child Health and Human Development.

In addition, we address the regulatory mechanisms of gene expression and the control mechanisms of DNA replication.

The second scientist I'd like to meet would be the late Harold «Hal» Weintraub, who was a pioneer in cellular reprogramming and mechanisms of gene regulation.

Combined with the right computational approaches, scNMT - seq has the potential to reveal undiscovered mechanisms of gene regulation, both in development and disease.»

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.

There already has been great effort to elucidate the mechanisms of gene expression regulation, but it will be important to continue research to fully realize the potential of these epigenetic therapies and their applications in clinical settings.

This study provided detailed insight into the regulatory mechanisms of gene expression.

So great is the efficiency of the Mendelian mechanism of gene recombination that only a minuscule fraction of the potentially possible gene combinations can ever be realized.

By the 1960s the mechanisms of genes were crudely grasped.

He also isn't convinced that this mechanism of gene evolution is prominent in other venomous groups.

Based largely on studies of snakes, spiders and other species dangerous to our own, it is thought that most venom genes arise through the mechanism of gene duplication followed by mutation and repurposing (which scientists refer to as neofunctionalization).

University of Alabama at Birmingham researchers show, for the first time, that the well - known mechanism of gene expression control — dynamic changes in DNA methylation — is also involved in changes to the excitability of neural cells.

Ullu was recognized for her lab's work with the protozoan parasite Trypanosoma brucei, which causes African sleeping sickness, to uncover a novel mechanism of gene silencing known as RNA interference.

However, sex differences in regulatory mechanisms of genes could be the key element in explaining sexual dimorphism, leading to variations in phenotype through gene - environment interactions (194).

Cheng - Wen Wu is best known for his pioneering work on the four - step mechanism of gene transcription: DNA binding, RNA chain initiation, elongation and termination.

The 2006 Nobel Prize in Physiology or Medicine recognized the discovery RNA interference (RNAi), a basic mechanism of gene regulation that also provides an important new tool for functional genome analysis.

Not exact matches

The mechanism then turns off both copies of the browning gene.

To coax the apples to create these particular anti-browning RNA molecules, the scientists gave the apple extra copies of the browning gene that were tweaked to set off the plant's interference mechanism.

And a third, different kind of gene therapy from Spark Therapeutics — to treat a rare inherited form of blindness — is likely to be approved by the end of 2017, too, making this year a landmark for treatments that manipulate the body's own biological mechanisms in novel new ways to fight deadly diseases.

Very well, Chad, be the former and lay out your explanation for how theistic evolution works, including the mechanisms by which God intervenes in the world of gene frequencies, the physical process by which God «orchestrates» the universe, and the observations that this understanding is based upon.

A number of time I have offered Chad the opportunity to present his explanation for how theistic evolution works, the mechanisms by which God intervenes in the world of gene frequencies, and the physical process by which God «orchestrates» the universe.

In 1953 with the discovery of the double helix of the DNA molecule, which led to the eventual decoding of our genes, we now have access to what would seem to be the basic mechanism through which evolution occurs.

What drew them into this exploratory process was not a Darwinian drive to the enhanced propagation of their genes, but an entirely different mechanism.

Epigenetics (literally «above the gene») is a recent scientific development that examines how particular mechanisms can influence whether certain genes are turned off, turned on, or modify a gene's level of activity.

Two of these mechanisms, DNA methylation and histone modification, regulate how readily genes encoded in the DNA can be expressed.

When looking into mechanisms that might affect the levels of SMN protein in neurons, the researchers scanned a genomic database called the UCSC Genome Browser and identified two genetic sequences that matched the opposite DNA strand of the SMN gene.

The study sheds light on the mechanisms and adaptive significance of gene family evolution.

The discovery of a new mechanism for shutting down imprinted genes also raises many provocative questions, Zhang says.

Researchers still have much to learn about the imprinting process and the genes involved, Zhang says, but the discovery of a second mechanism for silencing one copy of these genes underscores imprinting's importance.

For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.

Specifically, the study reveals a mechanism that helps explain how dividing cells pass patterns of epigenetic information called methyl tags to their daughter cells, a crucial part of regulating gene expression across cell generations.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

Concentration dependence and combinatorial regulation together open up a versatile repertoire of pattern - forming mechanisms that can realize the designs encoded in genes.

Because this imprinting affects hundreds of genes that are non-coding, including microRNAs and non-coding RNAs, it's a very interesting fine - tuning mechanism for the dosage of gene expression in the brain and elsewhere in the body.»

«Autism's social deficits are reversed by an anti-cancer drug: Using an epigenetic mechanism, romidepsin restored gene expression and alleviated social deficits in animal models of autism.»

For example, in sporadic PD, multiple GWAS point to the alpha - synuclein gene (SNCA) as one of the strongest risk loci in patients» genomes, yet GWAS contain little information regarding the mechanism of how this gene is dysregulated in sporadic PD patients.

It is currently unclear why this is so, despite the apparent existence of a mechanism that makes it hard for orphan genes to «survive» on the X chromosome.

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

Messenger RNA (mRNA) serves as an important intermediary during gene expression, by relating the genetic information of DNA to the molecular mechanisms involved in manufacturing proteins.

Whether or not a gay gene, a set of gay genes, or some other biological mechanism is ever found, one thing is clear: The environment a child grows up in has nothing to do with what makes most gay men gay.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

«Our study suggests that m6A - mediated adjustment of gene expression might be an ancient yet unexplored mechanism for the development of this diversity.»

With no viable testing mechanism on the horizon, it is possible that at least one of the 10,000 - plus Olympic competitors in Beijing this summer will have experimented with gene doping.

Last December, the same research team demonstrated blocking the expression of the gene that encodes apoC - III led to major relief of triglyceridemia in patients suffering a rare and extreme form of hypertriglyceridemia, which in turn opened the door for the identification of unexpected mechanisms that govern blood fat.

«Within the context of our emerging appreciation of polygenic risk, where gene variations are implicated in several disorders, the new findings point to only partial overlap in the risk mechanisms for these two forms of bipolar disorder,» said Dr. Krystal.