Sentences with phrase «mechanistic basis»

Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.

An extension of this model, however, proposes that EMT forms a key mechanistic basis for the progression of malignant tumors (reviewed by Nieto MA [1]-RRB-.

METHODS: We examined epigenomic data, allelic activity, motif conservation, regulator expression, and gene coexpression patterns, with the aim of dissecting the regulatory circuitry and mechanistic basis of the association between the FTO region and obesity.

Mechanistic Basis for Type 2 Long QT Syndrome Caused by KCNH2 Mutations that Disrupt Conserved Arginine Residues in the Voltage Sensor

Regenerative medicine represents a new frontier in science, which seeks to understand the mechanistic basis of tissue aging, repair, and regeneration and to leverage this knowledge to improve human health.

Jusko says his faculty members are primarily supported by NIH grants and typically employ PK / PD in almost every project that studies the mechanistic basis of drugs in animals or people.

Although the AOPs developed until now have addressed chemical toxicity, the approach also lends itself to describing the mechanistic basis to potential adverse effects caused by nanomaterials, as demonstrated very recently by the JRC.

That means plant breeders can use the germplasm to cross with their existing lines, while academics will be able to make use of it to understand the mechanistic basis of key traits in bread wheat

These findings also suggest a mechanistic basis for potential treatments involving the painless electrical stimulation of the amygdala, which are currently being studied in ongoing clinical trials.

«These results indicate that tamoxifen is a pharmacologically attractive scaffold for the development of new anti-cryptococcal drugs and provide a mechanistic base for its further optimization.»

Fourth, disease network analysis ultimately provides a mechanistic basis for defining phenotypic differences among individuals with the same disease through consideration of unique genetic and environmental factors that govern intermediate phenotypes contributing to disease expression.

The mechanistic basis for the observed differences is unclear.

For the current funding period, we aim to explore the mechanistic basis for differential signal activation and its spatiotemporal regulation by localization in different microcompartments.

The mechanistic basis of decreased memory establishment secondary to enhanced TCR signaling is an area of ongoing investigation.

The structures of membrane - bound BCL - 2 proteins have been long sought - after because they hold the keys for understanding the mechanistic basis of activity and for the development of selective drugs free of off - target effects.

In collaboration with the Juelicher group at the MPI - PKS and the Brusch group at the TUD, we are trying to understand the mechanistic basis of the dynamic steady state in close interplay between experiment and theory.

Currently, I am investigating the mechanistic basis of the relationship between reproduction and lifespan and also how this relationship is modulated by diet.

These funds allow early, high - risk research to move solid basic science findings toward clinical application, as well as the migration of provocative clinical observations back to the laboratory in order to understand their mechanistic basis.

This review explores the mechanistic basis of tumour cell invasion by focusing on the reorganisation of the dendritic actin network.

Pharmacological Research: «Cruciferous Vegetables and Human Cancer Risk: Epidemiological Evidence and Mechanistic Basis.»

Higdon J, Delage B, Williams D, Dashwood R. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.

In particular, in the face of uncertain coupling of natural and anthropogenic climate forcing, understanding the timing, extent and especially the mechanistic basis for baseline shifts now represents an urgent challenge.