Sentences with phrase «mechanistic basis for»

In particular, in the face of uncertain coupling of natural and anthropogenic climate forcing, understanding the timing, extent and especially the mechanistic basis for baseline shifts now represents an urgent challenge.

For the current funding period, we aim to explore the mechanistic basis for differential signal activation and its spatiotemporal regulation by localization in different microcompartments.

An extension of this model, however, proposes that EMT forms a key mechanistic basis for the progression of malignant tumors (reviewed by Nieto MA [1]-RRB-.

The mechanistic basis for the observed differences is unclear.

Fourth, disease network analysis ultimately provides a mechanistic basis for defining phenotypic differences among individuals with the same disease through consideration of unique genetic and environmental factors that govern intermediate phenotypes contributing to disease expression.

These findings also suggest a mechanistic basis for potential treatments involving the painless electrical stimulation of the amygdala, which are currently being studied in ongoing clinical trials.

«These results indicate that tamoxifen is a pharmacologically attractive scaffold for the development of new anti-cryptococcal drugs and provide a mechanistic base for its further optimization.»

Not exact matches

Sweeney found that the mechanistic answers that Pinker offered about the mind — the brain - based mechanisms of thought and consciousness being discovered by modern neuroscience — inspired her to replace her Catholic faith with science's empirical skepticism, which she finds, after many hilarious detours, «a much more powerful and reliable tool for understanding the world.»

The genetic basis for cardiomyopathy from mutation identification to mechanistic paradigms

When the mTORC1 (for «mechanistic target of rapamycin complex 1») pathway operates properly, it senses the amount of nutrients, specifically amino acids, available and restricts cell growth based on that level.

The symposium brings together leaders in biology, medicine, and industry to present on the latest advances in technology development, mechanistic understanding, and therapeutic application of stem cells for both drug development and cell - based therapy.

The structures of membrane - bound BCL - 2 proteins have been long sought - after because they hold the keys for understanding the mechanistic basis of activity and for the development of selective drugs free of off - target effects.

Our research programme is highly interdisciplinary, using the tools of chemical physics to understand the chemical basis for complex biological and mechanistic problems.

Previous work has given insights into the mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation of stable, monodisperse microdroplets; and integrated two contrasting modes of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.

We want to gain comprehensive mechanistic insight into the division of human mitotic cells, provide a biophysical basis to understand nuclear organisation, and establish methods for systems analysis of the first mitotic divisions of mammalian embryos.

Based on this information, the team developed a conceptual mechanistic model for how uraninite would react in groundwater.

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

The ultimate goal of this line of investigation is to leverage these newly gained mechanistic insights for developing new therapeutics in a personalized manner based on one's unique genetic and / or pathway signatures.

Identifying a reliable signature pattern of altered RS activity for chronic pain could provide strong mechanistic insights and serve as a highly beneficial neuroimaging - based diagnostic tool.

These data define a critical role for MORC2 in epigenetic silencing by the HUSH complex and provide a mechanistic basis underpinning the role of MORC2 mutations in CMT disease.

Knowledge gained from mechanistic studies may contribute to the design of allogeneic vaccine - based or adoptive immunotherapy for breast cancer.

[D] espite the strong mechanistic or physiological basis for a role of warming in coral bleaching and coral growth, a robust demonstration of a direct causal link between global warming and global coral bleaching over decadal time scales has not yet been produced.»

Despite these cautions, the data on the relationship between Dietary Fiber intake and risk of CHD based on epide - miological, clinical, and mechanistic data are strong enough to warrant using this relationship as a basis for setting a recommended level of intake.

His ideas were marked by a mechanistic materialist foundation, a characterization of human nature based on greed and fear of death, and support for an absolute monarchical form of government.

Photobiomodulation (PBM) is the term used to describe the mechanistic / scientific basis for this photonic specialty and photobiomodulation therapy (PBMT) as the term for its therapeutic application.

We don't know that for a fact in the real data, but to believe that they do on the basis of thinking you see such patterns (and with no reasonable mechanistic explanation) is sort of like continuing to believe Yuri Geller can bend spoons with his mind after James Randi has clearly demonstrated how he can just as convincingly bend spoons using slight - of - hand.

The Guidance Note for Lead Authors of the IPCC Fifth Assessment Report on Consistent Treatment of Uncertainties impose upon the lead authors to assign subjective levels of confidence to their findings: «The AR5 will rely on two metrics for communicating the degree of certainty in key findings: 1 Confidence in the validity of a finding, based on the type, amount, quality, and consistency of evidence (e.g., mechanistic understanding, theory, data, models, expert judgment) and the degree of agreement.