Sentences with phrase «mechanistic basis of»

Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.

The structures of membrane - bound BCL - 2 proteins have been long sought - after because they hold the keys for understanding the mechanistic basis of activity and for the development of selective drugs free of off - target effects.

The mechanistic basis of decreased memory establishment secondary to enhanced TCR signaling is an area of ongoing investigation.

Regenerative medicine represents a new frontier in science, which seeks to understand the mechanistic basis of tissue aging, repair, and regeneration and to leverage this knowledge to improve human health.

Not exact matches

I have a lot of faith in science, not in the unscientific assumption that atheists make that reality is purely mechanistic, but in the procedures of testing hypotheses, questioning assumptions, measuring results, replicating experiments, and in general debating and persuading based on actual evidence.

(11) The mechanistic metaphor causes Westerners to regard cultures that live on the basis of organic metaphors as «ignorant and confused.»

In this paper, I shall present a more adequate mechanistic position based on a contemporary image of a machine and attempt to show its relationship to the ecological model of Birch and Cobb.

The author presents a mechanistic position based on a contemporary image of a machine and attempts to show its relationship to the ecological model of Birch and Cobb, in which a classical mechanism is presented based on an outdated image of a machine.

Furthermore, interactions between the environment and the epigenome may provide mechanistic insight into many toxicological phenomena that are not well - understood, such as non-genotoxic carcinogenesis, age - based windows of susceptibility, developmental reprogramming by early life exposures, and trans - generational exposure effects.

After thoroughly reviewing the accumulated scientific literature, a Working Group of 22 experts from 10 countries convened by the IARC Monographs Programme classified the consumption of red meat as probably carcinogenic to humans (Group 2A), based on limited evidence that the consumption of red meat causes cancer in humans and strong mechanistic evidence supporting a carcinogenic effect.

Sweeney found that the mechanistic answers that Pinker offered about the mind — the brain - based mechanisms of thought and consciousness being discovered by modern neuroscience — inspired her to replace her Catholic faith with science's empirical skepticism, which she finds, after many hilarious detours, «a much more powerful and reliable tool for understanding the world.»

«This is a unique approach to obtain personalized, predictive and mechanistic descriptions of people's physiology based on their genetic and metabolic makeup,» said Palsson.

These findings also suggest a mechanistic basis for potential treatments involving the painless electrical stimulation of the amygdala, which are currently being studied in ongoing clinical trials.

«These results indicate that tamoxifen is a pharmacologically attractive scaffold for the development of new anti-cryptococcal drugs and provide a mechanistic base for its further optimization.»

The work, he says, «is really starting to give us some mechanistic understanding of the molecular basis of evolution.»

Fourth, disease network analysis ultimately provides a mechanistic basis for defining phenotypic differences among individuals with the same disease through consideration of unique genetic and environmental factors that govern intermediate phenotypes contributing to disease expression.

An extension of this model, however, proposes that EMT forms a key mechanistic basis for the progression of malignant tumors (reviewed by Nieto MA [1]-RRB-.

«Long - term projections of the type presented here are always crude caricatures but I like this study because it does take a more mechanistic approach based on the known habitat requirements of the species rather than using a more traditional and simplistic thermal envelope model,» he said.

When the mTORC1 (for «mechanistic target of rapamycin complex 1») pathway operates properly, it senses the amount of nutrients, specifically amino acids, available and restricts cell growth based on that level.

The symposium brings together leaders in biology, medicine, and industry to present on the latest advances in technology development, mechanistic understanding, and therapeutic application of stem cells for both drug development and cell - based therapy.

Our research programme is highly interdisciplinary, using the tools of chemical physics to understand the chemical basis for complex biological and mechanistic problems.

Previous work has given insights into the mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation of stable, monodisperse microdroplets; and integrated two contrasting modes of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.

The successful candidate will provide expertise to assess the human safety of Unilever ingredients within multidisciplinary teams developing & applying novel, mechanistic / pathways based approaches.

We want to gain comprehensive mechanistic insight into the division of human mitotic cells, provide a biophysical basis to understand nuclear organisation, and establish methods for systems analysis of the first mitotic divisions of mammalian embryos.

The proposal, based on published experimental results and a validated computer simulation of neural networks, derives its mechanistic framework from the intimate connection in mindfulness between mind and body, since standardized mindfulness meditation training begins with a highly localized focus on body and breath sensations.

Finally, due to the mechanistic nature of the climate forcing models, we project historical and future nesting trajectories based on available climate data and under different climate change scenarios.

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

The ultimate goal of this line of investigation is to leverage these newly gained mechanistic insights for developing new therapeutics in a personalized manner based on one's unique genetic and / or pathway signatures.

Identifying a reliable signature pattern of altered RS activity for chronic pain could provide strong mechanistic insights and serve as a highly beneficial neuroimaging - based diagnostic tool.

These data define a critical role for MORC2 in epigenetic silencing by the HUSH complex and provide a mechanistic basis underpinning the role of MORC2 mutations in CMT disease.

Knowledge gained from mechanistic studies may contribute to the design of allogeneic vaccine - based or adoptive immunotherapy for breast cancer.

My group has explored the mechanistic and quantitative basis of variation in these signals, as well as how they are used in communication and respond under varied selective regimes.

[D] espite the strong mechanistic or physiological basis for a role of warming in coral bleaching and coral growth, a robust demonstration of a direct causal link between global warming and global coral bleaching over decadal time scales has not yet been produced.»

Other publications on cancer chemoprevention include Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials, Chemopreventive effects of natural dietary compounds on cancer development, Organosulfur compounds in cancer chemoprevention, Cancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium.

Despite these cautions, the data on the relationship between Dietary Fiber intake and risk of CHD based on epide - miological, clinical, and mechanistic data are strong enough to warrant using this relationship as a basis for setting a recommended level of intake.

In phony merit pay — the kind that hardly exists in any industry — there is a mechanistic calculation of performance that determines the size of a small bonus that is provided in addition to a base salary that is essentially guaranteed regardless of performance.

Further, Tanner points out that the 1920s was a time period when much of the research on intelligence was mechanistic and heavily based on eugenics, whereas the critical factor is environmental.

His ideas were marked by a mechanistic materialist foundation, a characterization of human nature based on greed and fear of death, and support for an absolute monarchical form of government.

(2) In my view, there are very likely strong mechanistic links between the outcomes of Bob's analyses (briefly noting that most of his historic data is based on shipboard measurements) and the biophysical effects I am referring - to — especially from the later 20th century to now.

We don't know that for a fact in the real data, but to believe that they do on the basis of thinking you see such patterns (and with no reasonable mechanistic explanation) is sort of like continuing to believe Yuri Geller can bend spoons with his mind after James Randi has clearly demonstrated how he can just as convincingly bend spoons using slight - of - hand.

The Guidance Note for Lead Authors of the IPCC Fifth Assessment Report on Consistent Treatment of Uncertainties impose upon the lead authors to assign subjective levels of confidence to their findings: «The AR5 will rely on two metrics for communicating the degree of certainty in key findings: 1 Confidence in the validity of a finding, based on the type, amount, quality, and consistency of evidence (e.g., mechanistic understanding, theory, data, models, expert judgment) and the degree of agreement.

Projections of key variables in a realistic model should not be based on mechanistic temporal extrapolations of those variables but rather on the intrinsic internal dynamics of the system.

In particular, in the face of uncertain coupling of natural and anthropogenic climate forcing, understanding the timing, extent and especially the mechanistic basis for baseline shifts now represents an urgent challenge.