Sentences with phrase «mechanistic insights»

By providing mechanistic insights into how these bacteria interact with the host, this research will contribute to efforts to devise these future therapies.

New Danish research provides mechanistic insight into how DNA is monitored and repaired if damage occurs.

Our experiment provides new mechanistic insights into the role of memory systems in informing this process.

The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease.

Application of Tissue - Engineered Humanized Bone Models Reveals New Mechanistic Insights of beta 1 Integrins in Breast Cancer Bone Colonization.

Their goal is to generate hypotheses and enable their testing and validation, in order to reveal novel mechanistic insights for predictive and / or therapeutic paradigms.

The ultimate goal of this line of investigation is to leverage these newly gained mechanistic insights for developing new therapeutics in a personalized manner based on one's unique genetic and / or pathway signatures.

Such work yields unique mechanistic insight by directly illustrating the complex spatial - temporal dynamics of fundamental cellular processes such as mitosis, morphogenesis, polarization, embryonic development, membrane trafficking and cytoskeleton dynamics.

Professor Wolf Reik, Head of the Epigenetics research programme, said: «Charting the different developmental timings in the early reprogramming events observed in the human and mouse - derived cells gives the first mechanistic insight into how these events are regulated which is tremendously exciting.

«Our structures of the complexes of the circadian clock proteins of cyanobacteria provided important mechanistic insights, but are static snapshots of a system that's continuously moving and changing hour by hour,» said LiWang.

The world seemed simpler in the 1970s, when molecular biology brought us concepts such as «gene A leads to protein B, which leads to function C.» Thinking this way, scientists uncovered amazing mechanistic insights and, sometimes, designed effective drugs — the cancer drug Gleevec is the poster child of that reductionist approach.

The strategy and mechanistic insights from the work on sodium chloride provides a blueprint for predicting growth rates in materials synthesis, pharmaceuticals and biomineralization.

Together, the expected results will provide fundamental mechanistic insights into the structure and function of the newly discovered interbacterial nanotubes.

In this way, mechanistic insights guide how to make systems that have the functional properties we need,» said Sharp.

We want to gain comprehensive mechanistic insight into the division of human mitotic cells, provide a biophysical basis to understand nuclear organisation, and establish methods for systems analysis of the first mitotic divisions of mammalian embryos.

New mechanistic insights of integrin ß1 in breast cancer bone colonization.

«Taken together, our findings provide novel mechanistic insights into the initial stage of a new type of neuronal plasticity in health and disease,» says Gu, who points out that axonal varicosities have also been observed in healthy brains where neurons may respond to mechanical signals from their environment.

The journal focuses on analyses at the molecular level, with an emphasis on new mechanistic insights.

Probiotic strains and mechanistic insights for the treatment of type 2 diabetes.

«Having identified a link between cytoskeleton dynamics and Zika virus replication, together with the plethora of available cytoskeleton - targeting compounds, might contribute to gain mechanistic insight into the ZIKV replication cycle and identify new avenues for treatment,» Bartenschlager says.

These unique experimental models have been yielded mechanistic insight and potential new therapeutic avenues.

Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance.

This direct link between Exocyst and WRC complexes provides a novel mechanistic insight into the spatio - temporal regulation of cell migration.

Furthermore, interactions between the environment and the epigenome may provide mechanistic insight into many toxicological phenomena that are not well - understood, such as non-genotoxic carcinogenesis, age - based windows of susceptibility, developmental reprogramming by early life exposures, and trans - generational exposure effects.

«This work represents a mechanistic insight that could lead to the development of a new therapeutic approach for preventing asthma.»

Molecular dynamics and density functional theory calculations provide mechanistic insights into the reaction steps.

«But this is an important first step toward our long - term goal of leveraging the deep, mechanistic insights that we have uncovered for a gut - brain connection to help ease the medical, economic, and social burden of Parkinson's disease.»

With these new mechanistic insights into bright rod vision, however, there may be new possibilities for therapies for patients without functional cone vision.

«People still don't entirely know why gold - palladium is so selective,» Wilson added, but it seems that this new mechanistic insight will help to explain the selectivity of these materials.

«With this mechanistic insight,» he notes, «we might finally be able to look at questions like that one.»

Describe how protein profile comparisons of Alzheimer's disease and multiple sclerosis reveal important pathophysiological and mechanistic insights

«We continued to look into this phenomena to gain mechanistic insight and found evidence of a unique three - step mechanism for polytubey block, where the egg cell and the central cell coordinately play key roles in eliminating the persistent synergid cell by cell fusion and subsequent nuclear disorganization.»

Notophthalmus viridescens, an urodelian amphibian, represents an excellent model organism to study regenerative processes, but mechanistic insights into molecular processes driving regeneration have been hindered by a paucity and poor annotation of coding nucleotide sequences.

«The data presented at AACR provide important new models and mechanistic insights that inform our planned development efforts to evaluate the ability of microbiome therapy to augment immune checkpoint inhibitors,» said David Cook, Ph.D., Chief Scientific Officer and Executive Vice President of Research at Seres.

Mechanistic Insights into Chemical and Photochemical Transformations of Bismuth Vanadate Photoanodes F. M. Toma, J. K. Cooper, V. Kunzelmann, M. T. McDowell, J. Yu, D. Larson, N. J. Borys, J. W. Beeman, F. A. Houle, K. A. Oersson, and I. D. Sharp

Fluorescence Cross-Correlation Spectroscopy Reveals Mechanistic Insights into the Effect of 2» - O - Methyl Modified siRNAs in Living Cells.

Astrocytes and neuroprotection: mechanistic insights into the roles of glutamate transporters and hypoxia - inducible factor (HIF)

The Liver - Chip also provided mechanistic insight into drug action.

Dotiwala studies the mechanisms by which cell - based innate and adaptive immunity destroy diverse non-viral pathogens, with the aim of applying these mechanistic insights to aid in designing better antimicrobial and anti-cancer therapies.

Mechanistic Insights into MHC class II proteins using Molecular Dynamics Simulations and Markov State Modeling

Although hereditary kidney cancer syndrome accounts for approximately five percent of all kidney cancers, the mechanistic insight into tumor development in these rare conditions has provided the foundation for the development of molecular targeting agents currently used for sporadic...

Although the underlying mechanisms remain largely unknown, particularly in humans, mechanistic insights are emerging from experimental model systems, which may have implications for understanding disease and development.

Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori - induced neoplasias but also are providing mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

Multiple types of spectroscopy and electron microscopy capabilities available at EMSL, the Environmental Molecular Sciences Laboratory, a DOE Office of Science user facility on the PNNL campus, allowed the scientists to understand the catalyst surface at the atomic level and provide mechanistic insight into how oxygen vacancies migrate to the surface of the cerium oxide, creating pathways for highly active carbon monoxide conversion.

Studying DNA methylation in the window of conception leads also to mechanistic insights into the spatio - temporal control of genomic methylation specificity, including components of histone modification and RNA - directed pathways (small and long).