Sentences with phrase «mechanistic insights for»

Probiotic strains and mechanistic insights for the treatment of type 2 diabetes.

The ultimate goal of this line of investigation is to leverage these newly gained mechanistic insights for developing new therapeutics in a personalized manner based on one's unique genetic and / or pathway signatures.

Their goal is to generate hypotheses and enable their testing and validation, in order to reveal novel mechanistic insights for predictive and / or therapeutic paradigms.

Not exact matches

«This work represents a mechanistic insight that could lead to the development of a new therapeutic approach for preventing asthma.»

«Having identified a link between cytoskeleton dynamics and Zika virus replication, together with the plethora of available cytoskeleton - targeting compounds, might contribute to gain mechanistic insight into the ZIKV replication cycle and identify new avenues for treatment,» Bartenschlager says.

Previous work has given insights into the mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation of stable, monodisperse microdroplets; and integrated two contrasting modes of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.

Although the underlying mechanisms remain largely unknown, particularly in humans, mechanistic insights are emerging from experimental model systems, which may have implications for understanding disease and development.

We want to gain comprehensive mechanistic insight into the division of human mitotic cells, provide a biophysical basis to understand nuclear organisation, and establish methods for systems analysis of the first mitotic divisions of mammalian embryos.

As we demonstrate here, climate models provide new insights into the historical, current, and future populations of marine turtles and provide a mechanistic modeling framework for considering anthropogenic climate change.

Multiple types of spectroscopy and electron microscopy capabilities available at EMSL, the Environmental Molecular Sciences Laboratory, a DOE Office of Science user facility on the PNNL campus, allowed the scientists to understand the catalyst surface at the atomic level and provide mechanistic insight into how oxygen vacancies migrate to the surface of the cerium oxide, creating pathways for highly active carbon monoxide conversion.

This 3D proteomics brain data can be integrated with parallel 3D transcriptomic studies to possibly provide insights to interesting targets for either therapeutic intervention or further mechanistic studies.

Identifying a reliable signature pattern of altered RS activity for chronic pain could provide strong mechanistic insights and serve as a highly beneficial neuroimaging - based diagnostic tool.

For the correlative and mechanistic approaches, studies and insights from the present give rise to the assumption that the same relationships will hold in the future.