Sentences with phrase «mechanistic insights into»

Studying DNA methylation in the window of conception leads also to mechanistic insights into the spatio - temporal control of genomic methylation specificity, including components of histone modification and RNA - directed pathways (small and long).

Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori - induced neoplasias but also are providing mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

Mechanistic Insights into MHC class II proteins using Molecular Dynamics Simulations and Markov State Modeling

Our experiment provides new mechanistic insights into the role of memory systems in informing this process.

Fluorescence Cross-Correlation Spectroscopy Reveals Mechanistic Insights into the Effect of 2» - O - Methyl Modified siRNAs in Living Cells.

Together, the expected results will provide fundamental mechanistic insights into the structure and function of the newly discovered interbacterial nanotubes.

Mechanistic Insights into Chemical and Photochemical Transformations of Bismuth Vanadate Photoanodes F. M. Toma, J. K. Cooper, V. Kunzelmann, M. T. McDowell, J. Yu, D. Larson, N. J. Borys, J. W. Beeman, F. A. Houle, K. A. Oersson, and I. D. Sharp

Analysis of Chemical and Biological Features Yields Mechanistic Insights into Drug Side Effects Miquel Duran - Frigola and Patrick Aloy Chemistry and Biology (2013): http://dx.doi.org/10.1016/j.chembiol.2013.03.017

Notophthalmus viridescens, an urodelian amphibian, represents an excellent model organism to study regenerative processes, but mechanistic insights into molecular processes driving regeneration have been hindered by a paucity and poor annotation of coding nucleotide sequences.

Molecular dynamics and density functional theory calculations provide mechanistic insights into the reaction steps.

By providing mechanistic insights into how these bacteria interact with the host, this research will contribute to efforts to devise these future therapies.

Furthermore, interactions between the environment and the epigenome may provide mechanistic insight into many toxicological phenomena that are not well - understood, such as non-genotoxic carcinogenesis, age - based windows of susceptibility, developmental reprogramming by early life exposures, and trans - generational exposure effects.

«Having identified a link between cytoskeleton dynamics and Zika virus replication, together with the plethora of available cytoskeleton - targeting compounds, might contribute to gain mechanistic insight into the ZIKV replication cycle and identify new avenues for treatment,» Bartenschlager says.

Professor Wolf Reik, Head of the Epigenetics research programme, said: «Charting the different developmental timings in the early reprogramming events observed in the human and mouse - derived cells gives the first mechanistic insight into how these events are regulated which is tremendously exciting.

This direct link between Exocyst and WRC complexes provides a novel mechanistic insight into the spatio - temporal regulation of cell migration.

The Liver - Chip also provided mechanistic insight into drug action.

We want to gain comprehensive mechanistic insight into the division of human mitotic cells, provide a biophysical basis to understand nuclear organisation, and establish methods for systems analysis of the first mitotic divisions of mammalian embryos.

The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease.

Multiple types of spectroscopy and electron microscopy capabilities available at EMSL, the Environmental Molecular Sciences Laboratory, a DOE Office of Science user facility on the PNNL campus, allowed the scientists to understand the catalyst surface at the atomic level and provide mechanistic insight into how oxygen vacancies migrate to the surface of the cerium oxide, creating pathways for highly active carbon monoxide conversion.

74/4: 15 Functional analyses of type 2 diabetes - associated loci provides mechanistic insight into genetic susceptibility.

Not exact matches

In its encounter with the sciences, process thought has not only appropriated new scientific insights but has attempted a mutual transformation through which the sciences are liberated from the dominance of the mechanistic, deterministic, substantialist view into a holistic relational vision that is more coherent, consistent, adequate to the facts, and congruent with the best in the contemporary scientific enterprise itself.

As researchers gradually gain more insight into the genome's hierarchy of structures, they will get closer to figuring out how this macromolecular wonder works in all of its vastness and mechanistic detail.

Previous work has given insights into the mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation of stable, monodisperse microdroplets; and integrated two contrasting modes of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.

As we demonstrate here, climate models provide new insights into the historical, current, and future populations of marine turtles and provide a mechanistic modeling framework for considering anthropogenic climate change.