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Mechanistic insights of complex insertional translocations.
Not exact matches
In its encounter with the sciences, process thought has not only appropriated new scientific
insights but has attempted a mutual transformation through which the sciences are liberated from the dominance
of the
mechanistic, deterministic, substantialist view into a holistic relational vision that is more coherent, consistent, adequate to the facts, and congruent with the best in the contemporary scientific enterprise itself.
Furthermore, interactions between the environment and the epigenome may provide
mechanistic insight into many toxicological phenomena that are not well - understood, such as non-genotoxic carcinogenesis, age - based windows
of susceptibility, developmental reprogramming by early life exposures, and trans - generational exposure effects.
«This work represents a
mechanistic insight that could lead to the development
of a new therapeutic approach for preventing asthma.»
«Having identified a link between cytoskeleton dynamics and Zika virus replication, together with the plethora
of available cytoskeleton - targeting compounds, might contribute to gain
mechanistic insight into the ZIKV replication cycle and identify new avenues for treatment,» Bartenschlager says.
«People still don't entirely know why gold - palladium is so selective,» Wilson added, but it seems that this new
mechanistic insight will help to explain the selectivity
of these materials.
Professor Wolf Reik, Head
of the Epigenetics research programme, said: «Charting the different developmental timings in the early reprogramming events observed in the human and mouse - derived cells gives the first
mechanistic insight into how these events are regulated which is tremendously exciting.
«Our structures
of the complexes
of the circadian clock proteins
of cyanobacteria provided important
mechanistic insights, but are static snapshots
of a system that's continuously moving and changing hour by hour,» said LiWang.
As researchers gradually gain more
insight into the genome's hierarchy
of structures, they will get closer to figuring out how this macromolecular wonder works in all
of its vastness and
mechanistic detail.
Notophthalmus viridescens, an urodelian amphibian, represents an excellent model organism to study regenerative processes, but
mechanistic insights into molecular processes driving regeneration have been hindered by a paucity and poor annotation
of coding nucleotide sequences.
Analysis
of Chemical and Biological Features Yields
Mechanistic Insights into Drug Side Effects Miquel Duran - Frigola and Patrick Aloy Chemistry and Biology (2013): http://dx.doi.org/10.1016/j.chembiol.2013.03.017
This direct link between Exocyst and WRC complexes provides a novel
mechanistic insight into the spatio - temporal regulation
of cell migration.
«The data presented at AACR provide important new models and
mechanistic insights that inform our planned development efforts to evaluate the ability
of microbiome therapy to augment immune checkpoint inhibitors,» said David Cook, Ph.D., Chief Scientific Officer and Executive Vice President
of Research at Seres.
Mechanistic Insights into Chemical and Photochemical Transformations
of Bismuth Vanadate Photoanodes F. M. Toma, J. K. Cooper, V. Kunzelmann, M. T. McDowell, J. Yu, D. Larson, N. J. Borys, J. W. Beeman, F. A. Houle, K. A. Oersson, and I. D. Sharp
Together, the expected results will provide fundamental
mechanistic insights into the structure and function
of the newly discovered interbacterial nanotubes.
Fluorescence Cross-Correlation Spectroscopy Reveals
Mechanistic Insights into the Effect
of 2» - O - Methyl Modified siRNAs in Living Cells.
Our experiment provides new
mechanistic insights into the role
of memory systems in informing this process.
During her residency in Human Genetics at the University
of Bonn she pursued her research interest both in immunology and human genetics by investigating expression quantitative trait loci (eQTLs), which underpin innate immune responses, and provide
mechanistic insights to complement genome - wide association studies.
Previous work has given
insights into the
mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use
of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation
of stable, monodisperse microdroplets; and integrated two contrasting modes
of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.
Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori - induced neoplasias but also are providing
mechanistic insights into other malignancies that arise within the context
of microbially initiated inflammatory states.
We want to gain comprehensive
mechanistic insight into the division
of human mitotic cells, provide a biophysical basis to understand nuclear organisation, and establish methods for systems analysis
of the first mitotic divisions
of mammalian embryos.
The lab investigates consequences
of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination
of biochemistry, cell and molecular biology with genome wide approaches to gain
mechanistic insight into how chromatin architecture is modified in disease.
As we demonstrate here, climate models provide new
insights into the historical, current, and future populations
of marine turtles and provide a
mechanistic modeling framework for considering anthropogenic climate change.
Studying DNA methylation in the window
of conception leads also to
mechanistic insights into the spatio - temporal control
of genomic methylation specificity, including components
of histone modification and RNA - directed pathways (small and long).
Multiple types
of spectroscopy and electron microscopy capabilities available at EMSL, the Environmental Molecular Sciences Laboratory, a DOE Office
of Science user facility on the PNNL campus, allowed the scientists to understand the catalyst surface at the atomic level and provide
mechanistic insight into how oxygen vacancies migrate to the surface
of the cerium oxide, creating pathways for highly active carbon monoxide conversion.
I think that this investment has accelerated to the pace
of research in the field
of glaucoma; the number
of publications that are really focusing on these
mechanistic insights have just exploded in the last ten years, so this investment by Glaucoma Research Foundation was really a catalyst that allowed us to dig in deeper to understanding what's actually happening in the disease as the disease is progressing.
The ultimate goal
of this line
of investigation is to leverage these newly gained
mechanistic insights for developing new therapeutics in a personalized manner based on one's unique genetic and / or pathway signatures.
Identifying a reliable signature pattern
of altered RS activity for chronic pain could provide strong
mechanistic insights and serve as a highly beneficial neuroimaging - based diagnostic tool.
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of type 2 diabetes - associated loci provides
mechanistic insight into genetic susceptibility.
Such work yields unique
mechanistic insight by directly illustrating the complex spatial - temporal dynamics
of fundamental cellular processes such as mitosis, morphogenesis, polarization, embryonic development, membrane trafficking and cytoskeleton dynamics.
Probiotic strains and
mechanistic insights for the treatment
of type 2 diabetes.
A limitation
of the
insights from the energy balance is that they do not provide a closed
mechanistic understanding
of what controls the ITCZ position.
The article is interesting in my opinion since it gives some
mechanistic insight on one
of the many homeostatic temperature regulators.